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Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis.

Mao XM, Zhou P, Li SY, Zhang XY, Shen JX, Chen QX, Zhuang JX, Shen DY.

Onco Targets Ther. 2019 Nov 4;12:9093-9104. doi: 10.2147/OTT.S226261. eCollection 2019.


Forced overexpression of FBP1 inhibits proliferation and metastasis in cholangiocarcinoma cells via Wnt/β-catenin pathway.

Zhao W, Yang S, Chen J, Zhao J, Dong J.

Life Sci. 2018 Oct 1;210:224-234. doi: 10.1016/j.lfs.2018.09.009. Epub 2018 Sep 4.


Delicaflavone induces apoptosis via mitochondrial pathway accompanying G2/M cycle arrest and inhibition of MAPK signaling cascades in cervical cancer HeLa cells.

Yao W, Lin Z, Wang G, Li S, Chen B, Sui Y, Huang J, Liu Q, Shi P, Lin X, Liu Q, Yao H.

Phytomedicine. 2019 Sep;62:152973. doi: 10.1016/j.phymed.2019.152973. Epub 2019 May 25.


Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1.

Ding X, Zhang B, Pei Q, Pan J, Huang S, Yang Y, Zhu Z, Lv Y, Zou X.

BMC Cancer. 2014 Apr 17;14:271. doi: 10.1186/1471-2407-14-271.


Schisandrin B inhibits cell proliferation and induces apoptosis in human cholangiocarcinoma cells.

Yang X, Wang S, Mu Y, Zheng Y.

Oncol Rep. 2016 Oct;36(4):1799-806. doi: 10.3892/or.2016.4992. Epub 2016 Aug 2.


Apoptosis of human cholangiocarcinoma cells induced by ESC-3 from Crocodylus siamensis bile.

Song W, Shen DY, Kang JH, Li SS, Zhan HW, Shi Y, Xiong YX, Liang G, Chen QX.

World J Gastroenterol. 2012 Feb 21;18(7):704-11. doi: 10.3748/wjg.v18.i7.704.


Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells.

Ke F, Wang Z, Song X, Ma Q, Hu Y, Jiang L, Zhang Y, Liu Y, Zhang Y, Gong W.

Drug Des Devel Ther. 2017 Jun 15;11:1753-1766. doi: 10.2147/DDDT.S132488. eCollection 2017.


Knockdown of tripartite motif 59 (TRIM59) inhibits proliferation in cholangiocarcinoma via the PI3K/AKT/mTOR signalling pathway.

Shen H, Zhang J, Zhang Y, Feng Q, Wang H, Li G, Jiang W, Li X.

Gene. 2019 May 25;698:50-60. doi: 10.1016/j.gene.2019.02.044. Epub 2019 Feb 27.


Indirubin-3'-oxime suppresses human cholangiocarcinoma through cell-cycle arrest and apoptosis.

Lee MY, Li YZ, Huang KJ, Huang HC, Lin CY, Lee YR.

Eur J Pharmacol. 2018 Nov 15;839:57-65. doi: 10.1016/j.ejphar.2018.09.023. Epub 2018 Sep 27.


Total saponins of Albiziae Cortex show anti-hepatoma carcinoma effects by inducing S phase arrest and mitochondrial apoptosis pathway activation.

Qian Y, Han QH, Wang LC, Guo Q, Wang XD, Tu PF, Zeng KW, Liang H.

J Ethnopharmacol. 2018 Jul 15;221:20-29. doi: 10.1016/j.jep.2018.04.015. Epub 2018 Apr 12.


Decitabine inhibits the cell growth of cholangiocarcinoma in cultured cell lines and mouse xenografts.

Wang B, Li H, Yang R, Zhou S, Zou S.

Oncol Lett. 2014 Nov;8(5):1919-1924. Epub 2014 Sep 4.


[Effects of CPUY013, a novel Topo I inhibitor, on human gastric adenocarcinoma BGC823 cells in vitro and in vivo].

Ji YB, Zhou JH, Zuo MX, You QD.

Yao Xue Xue Bao. 2008 Aug;43(8):811-8. Chinese.


Apoptosis of human cholangiocarcinoma cell lines induced by β-escin through mitochondrial caspase-dependent pathway.

Shen DY, Kang JH, Song W, Zhang WQ, Li WG, Zhao Y, Chen QX.

Phytother Res. 2011 Oct;25(10):1519-26. doi: 10.1002/ptr.3435. Epub 2011 Mar 11.


Cinobufagin Induces Apoptosis in Osteosarcoma Cells Via the Mitochondria-Mediated Apoptotic Pathway.

Dai G, Zheng D, Guo W, Yang J, Cheng AY.

Cell Physiol Biochem. 2018;46(3):1134-1147. doi: 10.1159/000488842. Epub 2018 Apr 13.


Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo.

Xu D, Ma Y, Zhao B, Li S, Zhang Y, Pan S, Wu Y, Wang J, Wang D, Pan H, Liu L, Jiang H.

Oncol Rep. 2014 May;31(5):2063-70. doi: 10.3892/or.2014.3059. Epub 2014 Mar 5.


Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma.

Chen H, Zhu B, Zhao L, Liu Y, Zhao F, Feng J, Jin Y, Sun J, Geng R, Wei Y.

Cell Physiol Biochem. 2018;47(2):641-653. doi: 10.1159/000490019. Epub 2018 May 22.


Aberrant expression of NF-κB in liver fluke associated cholangiocarcinoma: implications for targeted therapy.

Seubwai W, Wongkham C, Puapairoj A, Khuntikeo N, Pugkhem A, Hahnvajanawong C, Chaiyagool J, Umezawa K, Okada S, Wongkham S.

PLoS One. 2014 Aug 29;9(8):e106056. doi: 10.1371/journal.pone.0106056. eCollection 2014.


Luteolin arrests cell cycling, induces apoptosis and inhibits the JAK/STAT3 pathway in human cholangiocarcinoma cells.

Aneknan P, Kukongviriyapan V, Prawan A, Kongpetch S, Sripa B, Senggunprai L.

Asian Pac J Cancer Prev. 2014;15(12):5071-6.


β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma.

Huang GL, Shen DY, Cai CF, Zhang QY, Ren HY, Chen QX.

World J Gastroenterol. 2015 Jan 28;21(4):1148-57. doi: 10.3748/wjg.v21.i4.1148.


Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis.

Zhang M, Pan Y, Tang D, Dorfman RG, Xu L, Zhou Q, Zhou L, Wang Y, Li Y, Yin Y, Kong B, Friess H, Zhao S, Wu JL, Wang L, Zou X.

Cell Commun Signal. 2019 Mar 12;17(1):23. doi: 10.1186/s12964-019-0332-8. Erratum in: Cell Commun Signal. 2019 May 6;17(1):43.

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