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Items: 1 to 20 of 103

1.

Pharmacological Targeting of BET Bromodomains Inhibits Lens Fibrosis via Downregulation of MYC Expression.

Wang X, Wang B, Zhao N, Wang C, Huang M, Chen B, Chen J, Sun Y, Xiong L, Huang S, Liu Y.

Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4748-4758. doi: 10.1167/iovs.19-27596.

PMID:
31731295
2.

HMGA2 Modulates the TGFβ/Smad, TGFβ/ERK and Notch Signaling Pathways in Human Lens Epithelial-Mesenchymal Transition.

Hou M, Bao X, Luo F, Chen X, Liu L, Wu M.

Curr Mol Med. 2018;18(2):71-82. doi: 10.2174/1566524018666180705104844.

PMID:
29974827
3.

Enhanced EGF receptor-signaling potentiates TGFβ-induced lens epithelial-mesenchymal transition.

Shu DY, Lovicu FJ.

Exp Eye Res. 2019 Aug;185:107693. doi: 10.1016/j.exer.2019.107693. Epub 2019 Jun 12.

PMID:
31201806
4.

Bone Morphogenetic Protein-7 Suppresses TGFβ2-Induced Epithelial-Mesenchymal Transition in the Lens: Implications for Cataract Prevention.

Shu DY, Wojciechowski MC, Lovicu FJ.

Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):781-796. doi: 10.1167/iovs.16-20611.

6.

CtBP2 Regulates TGFβ2-Induced Epithelial-Mesenchymal Transition Through Notch Signaling Pathway in Lens Epithelial Cells.

Zhang G, Kang L, Chen J, Xue Y, Yang M, Qin B, Yang L, Zhang J, Lu H, Guan H.

Curr Eye Res. 2016 Aug;41(8):1057-1063. Epub 2015 Dec 17.

PMID:
26681554
7.

Bit1-a potential positive regulator of epithelial-mesenchymal transition in lens epithelial cells.

Wu X, Ruan J, Ma B, Luo M.

Graefes Arch Clin Exp Ophthalmol. 2016 Jul;254(7):1311-8. doi: 10.1007/s00417-016-3357-3. Epub 2016 Apr 28.

PMID:
27122244
8.

Aspirin Inhibits TGFβ2-Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells: Selective acetylation of K56 and K122 in histone H3.

Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski Iv JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH.

Biochem J. 2019 Dec 9. pii: BCJ20190540. doi: 10.1042/BCJ20190540. [Epub ahead of print]

PMID:
31815277
9.
10.

ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition.

Shu DY, Wojciechowski M, Lovicu FJ.

Exp Eye Res. 2019 Jan;178:108-121. doi: 10.1016/j.exer.2018.09.021. Epub 2018 Oct 2.

PMID:
30290164
11.

FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.

Kubo E, Shibata S, Shibata T, Kiyokawa E, Sasaki H, Singh DP.

J Cell Mol Med. 2017 May;21(5):916-928. doi: 10.1111/jcmm.13030. Epub 2016 Dec 15.

12.

miRNA-181a inhibits the proliferation, migration, and epithelial-mesenchymal transition of lens epithelial cells.

Dong N, Tang X, Xu B.

Invest Ophthalmol Vis Sci. 2015 Jan 27;56(2):993-1001. doi: 10.1167/iovs.14-15860.

PMID:
25626972
13.

Histone deacetylase inhibitors trichostatin A and vorinostat inhibit TGFβ2-induced lens epithelial-to-mesenchymal cell transition.

Xie L, Santhoshkumar P, Reneker LW, Sharma KK.

Invest Ophthalmol Vis Sci. 2014 Jul 3;55(8):4731-40. doi: 10.1167/iovs.14-14109.

PMID:
24994865
14.

BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries.

Wang B, Zhang M, Takayama T, Shi X, Roenneburg DA, Kent KC, Guo LW.

EBioMedicine. 2015 Sep 28;2(11):1650-61. doi: 10.1016/j.ebiom.2015.09.045. eCollection 2015 Nov.

15.

BET bromodomain inhibition of MYC-amplified medulloblastoma.

Bandopadhayay P, Bergthold G, Nguyen B, Schubert S, Gholamin S, Tang Y, Bolin S, Schumacher SE, Zeid R, Masoud S, Yu F, Vue N, Gibson WJ, Paolella BR, Mitra SS, Cheshier SH, Qi J, Liu KW, Wechsler-Reya R, Weiss WA, Swartling FJ, Kieran MW, Bradner JE, Beroukhim R, Cho YJ.

Clin Cancer Res. 2014 Feb 15;20(4):912-25. doi: 10.1158/1078-0432.CCR-13-2281. Epub 2013 Dec 2.

16.

ERK1/2 signaling is required for the initiation but not progression of TGFβ-induced lens epithelial to mesenchymal transition (EMT).

Wojciechowski MC, Mahmutovic L, Shu DY, Lovicu FJ.

Exp Eye Res. 2017 Jun;159:98-113. doi: 10.1016/j.exer.2017.03.012. Epub 2017 Mar 30.

17.

GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.

Kumar K, Raza SS, Knab LM, Chow CR, Kwok B, Bentrem DJ, Popovic R, Ebine K, Licht JD, Munshi HG.

Sci Rep. 2015 Mar 25;5:9489. doi: 10.1038/srep09489.

18.

The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells.

Liu J, Xu D, Li J, Gao N, Liao C, Jing R, Wu B, Ma B, Shao Y, Pei C.

Int J Mol Med. 2018 Dec;42(6):3591-3601. doi: 10.3892/ijmm.2018.3912. Epub 2018 Oct 2.

PMID:
30280182
19.

Inhibition of BET bromodomain targets genetically diverse glioblastoma.

Cheng Z, Gong Y, Ma Y, Lu K, Lu X, Pierce LA, Thompson RC, Muller S, Knapp S, Wang J.

Clin Cancer Res. 2013 Apr 1;19(7):1748-59. doi: 10.1158/1078-0432.CCR-12-3066. Epub 2013 Feb 12.

20.

BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo.

Shao Q, Kannan A, Lin Z, Stack BC Jr, Suen JY, Gao L.

Cancer Res. 2014 Dec 1;74(23):7090-102. doi: 10.1158/0008-5472.CAN-14-0305. Epub 2014 Oct 2.

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