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Inhibition Of Mitochondrial Calcium Overload By SIRT3 Prevents Obesity Or Age-Related Whitening Of Brown Adipose Tissue.

Gao P, Jiang Y, Wu H, Sun F, Li Y, He H, Wang B, Lu Z, Hu Y, Wei X, Cui Y, He C, Wang L, Zheng H, Yang G, Liu D, Yan Z, Zhu Z.

Diabetes. 2019 Nov 11. pii: db190526. doi: 10.2337/db19-0526. [Epub ahead of print]


NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism.

Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E520-E530. doi: 10.1152/ajpendo.00057.2018. Epub 2018 Apr 10.


TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue.

Baskaran P, Krishnan V, Fettel K, Gao P, Zhu Z, Ren J, Thyagarajan B.

Int J Obes (Lond). 2017 May;41(5):739-749. doi: 10.1038/ijo.2017.16. Epub 2017 Jan 20.


A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice.

Kuipers EN, Held NM, In Het Panhuis W, Modder M, Ruppert PMM, Kersten S, Kooijman S, Guigas B, Houtkooper RH, Rensen PCN, Boon MR.

Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E820-E830. doi: 10.1152/ajpendo.00123.2019. Epub 2019 Aug 6.


Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics.

Flicker D, Sancak Y, Mick E, Goldberger O, Mootha VK.

Cell Rep. 2019 Apr 30;27(5):1364-1375.e5. doi: 10.1016/j.celrep.2019.04.013.


Vascular rarefaction mediates whitening of brown fat in obesity.

Shimizu I, Aprahamian T, Kikuchi R, Shimizu A, Papanicolaou KN, MacLauchlan S, Maruyama S, Walsh K.

J Clin Invest. 2014 May;124(5):2099-112. doi: 10.1172/JCI71643. Epub 2014 Apr 8.


A polyphenolic extract from green tea leaves activates fat browning in high-fat-diet-induced obese mice.

Neyrinck AM, Bindels LB, Geurts L, Van Hul M, Cani PD, Delzenne NM.

J Nutr Biochem. 2017 Nov;49:15-21. doi: 10.1016/j.jnutbio.2017.07.008. Epub 2017 Jul 24.


The Whitening of Brown Fat and Its Implications for Weight Management in Obesity.

Shimizu I, Walsh K.

Curr Obes Rep. 2015 Jun;4(2):224-9. doi: 10.1007/s13679-015-0157-8. Review.


Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening.

Deng J, Guo Y, Yuan F, Chen S, Yin H, Jiang X, Jiao F, Wang F, Ji H, Hu G, Ying H, Chen Y, Zhai Q, Xiao F, Guo F.

Autophagy. 2019 Jun 18:1-15. doi: 10.1080/15548627.2019.1628537. [Epub ahead of print]


Dietary fat overload reprograms brown fat mitochondria.

Lettieri Barbato D, Tatulli G, Vegliante R, Cannata SM, Bernardini S, Ciriolo MR, Aquilano K.

Front Physiol. 2015 Sep 29;6:272. doi: 10.3389/fphys.2015.00272. eCollection 2015.


Melinjo (Gnetum gnemon L.) seed extract induces uncoupling protein 1 expression in brown fat and protects mice against diet-induced obesity, inflammation, and insulin resistance.

Yoneshiro T, Kaede R, Nagaya K, Saito M, Aoyama J, Elfeky M, Okamatsu-Ogura Y, Kimura K, Terao A.

Nutr Res. 2018 Oct;58:17-25. doi: 10.1016/j.nutres.2018.06.012. Epub 2018 Jul 3.


High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.

Zeng H, Vaka VR, He X, Booz GW, Chen JX.

J Cell Mol Med. 2015 Aug;19(8):1847-56. doi: 10.1111/jcmm.12556. Epub 2015 Mar 17.


AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue.

Wu L, Zhang L, Li B, Jiang H, Duan Y, Xie Z, Shuai L, Li J, Li J.

Front Physiol. 2018 Feb 21;9:122. doi: 10.3389/fphys.2018.00122. eCollection 2018.


MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells.

Ren T, Zhang H, Wang J, Zhu J, Jin M, Wu Y, Guo X, Ji L, Huang Q, Zhang H, Yang H, Xing J.

Oncogene. 2017 Oct 19;36(42):5897-5909. doi: 10.1038/onc.2017.167. Epub 2017 Jun 26.


Ameliorating Endothelial Mitochondrial Dysfunction Restores Coronary Function via Transient Receptor Potential Vanilloid 1-Mediated Protein Kinase A/Uncoupling Protein 2 Pathway.

Xiong S, Wang P, Ma L, Gao P, Gong L, Li L, Li Q, Sun F, Zhou X, He H, Chen J, Yan Z, Liu D, Zhu Z.

Hypertension. 2016 Feb;67(2):451-60. doi: 10.1161/HYPERTENSIONAHA.115.06223. Epub 2015 Dec 14.


Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.

Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J.

Biochem Biophys Rep. 2017 Feb 20;10:32-38. doi: 10.1016/j.bbrep.2017.02.002. eCollection 2017 Jul.


Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.

Xu X, Zhu XP, Bai JY, Xia P, Li Y, Lu Y, Li XY, Gao X.

FASEB J. 2019 Jun;33(6):7289-7300. doi: 10.1096/fj.201802316R. Epub 2019 Mar 8.


Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.

Kwon S, Seok S, Yau P, Li X, Kemper B, Kemper JK.

J Biol Chem. 2017 Oct 20;292(42):17312-17323. doi: 10.1074/jbc.M117.778720. Epub 2017 Aug 14.


Calcium Supplementation Alleviates High-Fat Diet-Induced Estrous Cycle Irregularity and Subfertility Associated with Concomitantly Enhanced Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue.

Zhang F, Su H, Song M, Zheng J, Liu F, Yuan C, Fu Q, Chen S, Zhu X, Wang L, Gao P, Shu G, Jiang Q, Wang S.

J Agric Food Chem. 2019 Jun 26;67(25):7073-7081. doi: 10.1021/acs.jafc.9b02663. Epub 2019 Jun 17.


SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes.

Shi T, Wang F, Stieren E, Tong Q.

J Biol Chem. 2005 Apr 8;280(14):13560-7. Epub 2005 Jan 14.

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