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Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment.

Tamayo-Orrego L, Charron F.

F1000Res. 2019 Oct 29;8. pii: F1000 Faculty Rev-1823. doi: 10.12688/f1000research.20013.1. eCollection 2019. Review.


Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma.

Bhatia B, Potts CR, Guldal C, Choi S, Korshunov A, Pfister S, Kenney AM, Nahlé ZA.

Acta Neuropathol. 2012 Apr;123(4):587-600. doi: 10.1007/s00401-012-0968-6. Epub 2012 Mar 11.


Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma.

Bhatia B, Hsieh M, Kenney AM, Nahlé Z.

Oncogene. 2011 Jan 27;30(4):410-22. doi: 10.1038/onc.2010.454. Epub 2010 Oct 4. Erratum in: Oncogene. 2011 Jan 27;30(4):504.


p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor.

Bhatia B, Malik A, Fernandez-L A, Kenney AM.

Cell Cycle. 2010 Nov 1;9(21):4307-14. Epub 2010 Nov 27.


MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development.

Constantin L, Constantin M, Wainwright BJ.

Genetics. 2016 Mar;202(3):1105-18. doi: 10.1534/genetics.115.184176. Epub 2016 Jan 15.


YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.

Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL, Taylor MD, Angers S, Kenney AM.

Oncogene. 2016 Aug 11;35(32):4256-68. doi: 10.1038/onc.2015.491. Epub 2016 Jan 4.


A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.

Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, Taylor MD, Mitchell CA, Dyson JM.

Oncogene. 2017 Oct 26;36(43):5969-5984. doi: 10.1038/onc.2017.208. Epub 2017 Jun 26.


Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.

Malhotra A, Dey A, Prasad N, Kenney AM.

Mol Cancer Res. 2016 Jan;14(1):114-24. doi: 10.1158/1541-7786.MCR-15-0278. Epub 2015 Oct 7.


Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.

Shimada IS, Hwang SH, Somatilaka BN, Wang X, Skowron P, Kim J, Kim M, Shelton JM, Rajaram V, Xuan Z, Taylor MD, Mukhopadhyay S.

Cell Rep. 2018 Jan 30;22(5):1169-1184. doi: 10.1016/j.celrep.2018.01.018.


A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma.

White CL, Jayasekara WSN, Picard D, Chen J, Watkins DN, Cain JE, Remke M, Gough DJ.

Cancers (Basel). 2019 Nov 1;11(11). pii: E1702. doi: 10.3390/cancers11111702.


The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.

He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, Wang H, Deng Y, Yu Y, Xia Y, Wu X, Ramaswamy V, Hu T, Wang F, Zhou W, Burns DK, Kim SH, Kool M, Pfister SM, Weinstein LS, Pomeroy SL, Gilbertson RJ, Rubin JB, Hou Y, Wechsler-Reya R, Taylor MD, Lu QR.

Nat Med. 2014 Sep;20(9):1035-42. doi: 10.1038/nm.3666. Epub 2014 Aug 24.


Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth.

Binning MJ, Niazi T, Pedone CA, Lal B, Eberhart CG, Kim KJ, Laterra J, Fults DW.

Cancer Res. 2008 Oct 1;68(19):7838-45. doi: 10.1158/0008-5472.CAN-08-1899.


N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.

Browd SR, Kenney AM, Gottfried ON, Yoon JW, Walterhouse D, Pedone CA, Fults DW.

Cancer Res. 2006 Mar 1;66(5):2666-72.


Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells.

Colvin Wanshura LE, Galvin KE, Ye H, Fernandez-Zapico ME, Wetmore C.

Cancer Res. 2011 Aug 1;71(15):5336-45. doi: 10.1158/0008-5472.CAN-10-2633. Epub 2011 Jun 6.


ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas.

Grausam KB, Dooyema SDR, Bihannic L, Premathilake H, Morrissy AS, Forget A, Schaefer AM, Gundelach JH, Macura S, Maher DM, Wang X, Heglin AH, Ge X, Zeng E, Puget S, Chandrasekar I, Surendran K, Bram RJ, Schüller U, Talyor MD, Ayrault O, Zhao H.

Cancer Res. 2017 Jul 15;77(14):3766-3777. doi: 10.1158/0008-5472.CAN-16-1836. Epub 2017 May 10.


Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.

Lee SJ, Litan A, Li Z, Graves B, Lindsey S, Barwe SP, Langhans SA.

Mol Cancer. 2015 Aug 19;14:159. doi: 10.1186/s12943-015-0430-1.


Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.

Parathath SR, Mainwaring LA, Fernandez-L A, Campbell DO, Kenney AM.

Development. 2008 Oct;135(19):3291-300. doi: 10.1242/dev.022871. Epub 2008 Aug 28.


The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.

Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD.

Cancer Res. 2009 Apr 15;69(8):3249-55. doi: 10.1158/0008-5472.CAN-08-4710. Epub 2009 Apr 7.


c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice.

Rao G, Pedone CA, Coffin CM, Holland EC, Fults DW.

Neoplasia. 2003 May-Jun;5(3):198-204. doi: 10.1016/S1476-5586(03)80052-0.


Modeling medulloblastoma with genetically engineered mice.

Fults DW.

Neurosurg Focus. 2005 Nov 15;19(5):E7. Review.


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