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Items: 1 to 20 of 102

1.

Dithiocarbamate as a Valuable Scaffold for the Inhibition of Metallo-β-Lactmases.

Ge Y, Xu LW, Liu Y, Sun LY, Gao H, Li JQ, Yang K.

Biomolecules. 2019 Nov 5;9(11). pii: E699. doi: 10.3390/biom9110699.

2.

Amino Acid Thioesters Exhibit Inhibitory Activity against B1-B3 Subclasses of Metallo-β-lactamases.

Zhang YJ, Liu XL, Wang WM, Chen C, Zhao MH, Yang KW.

Chem Pharm Bull (Tokyo). 2019;67(2):135-142. doi: 10.1248/cpb.c18-00717.

3.

Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-β-lactamase Inhibitors.

Xiang Y, Chen C, Wang WM, Xu LW, Yang KW, Oelschlaeger P, He Y.

ACS Med Chem Lett. 2018 Mar 22;9(4):359-364. doi: 10.1021/acsmedchemlett.7b00548. eCollection 2018 Apr 12.

4.

Carbamylmethyl Mercaptoacetate Thioether: A Novel Scaffold for the Development of L1 Metallo-β-lactamase Inhibitors.

Chang YN, Xiang Y, Zhang YJ, Wang WM, Chen C, Oelschlaeger P, Yang KW.

ACS Med Chem Lett. 2017 Apr 24;8(5):527-532. doi: 10.1021/acsmedchemlett.7b00058. eCollection 2017 May 11.

5.

The assemblage of covalent and metal binding dual functional scaffold for cross-class metallo-β-lactamases inhibition.

Chen C, Liu Y, Zhang YJ, Ge Y, Lei JE, Yang KW.

Future Med Chem. 2019 Sep;11(18):2381-2394. doi: 10.4155/fmc-2019-0008. Epub 2019 Sep 23.

PMID:
31544522
6.

Amino Acid Thioester Derivatives: A Highly Promising Scaffold for the Development of Metallo-β-lactamase L1 Inhibitors.

Liu XL, Shi Y, Kang JS, Oelschlaeger P, Yang KW.

ACS Med Chem Lett. 2015 Apr 23;6(6):660-4. doi: 10.1021/acsmedchemlett.5b00098. eCollection 2015 Jun 11.

7.

Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors.

Zhang Y, Yan Y, Liang L, Feng J, Wang X, Li L, Yang K.

Molecules. 2019 Mar 25;24(6). pii: E1174. doi: 10.3390/molecules24061174.

8.

Triazolylthioacetamide: A Valid Scaffold for the Development of New Delhi Metallo-β-Lactmase-1 (NDM-1) Inhibitors.

Zhai L, Zhang YL, Kang JS, Oelschlaeger P, Xiao L, Nie SS, Yang KW.

ACS Med Chem Lett. 2016 Feb 16;7(4):413-7. doi: 10.1021/acsmedchemlett.5b00495. eCollection 2016 Apr 14.

9.

3-Bromopyruvate as a potent covalently reversible inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1).

Kang PW, Su JP, Sun LY, Gao H, Yang KW.

Eur J Pharm Sci. 2019 Nov 18:105161. doi: 10.1016/j.ejps.2019.105161. [Epub ahead of print]

PMID:
31751778
10.

Azolylthioacetamide: A Highly Promising Scaffold for the Development of Metallo-β-lactamase Inhibitors.

Yang SK, Kang JS, Oelschlaeger P, Yang KW.

ACS Med Chem Lett. 2015 Feb 12;6(4):455-60. doi: 10.1021/ml500534c. eCollection 2015 Apr 9.

11.

Azolylthioacetamides as a potent scaffold for the development of metallo-β-lactamase inhibitors.

Xiang Y, Chang YN, Ge Y, Kang JS, Zhang YL, Liu XL, Oelschlaeger P, Yang KW.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5225-5229. doi: 10.1016/j.bmcl.2017.10.038. Epub 2017 Oct 20.

PMID:
29122480
12.

Ebsulfur as a potent scaffold for inhibition and labelling of New Delhi metallo-β-lactamase-1 in vitro and in vivo.

Su J, Liu J, Chen C, Zhang Y, Yang K.

Bioorg Chem. 2019 Mar;84:192-201. doi: 10.1016/j.bioorg.2018.11.035. Epub 2018 Nov 22.

PMID:
30502631
13.

Mercaptoacetate thioesters and their hydrolysate mercaptoacetic acids jointly inhibit metallo-β-lactamase L1.

Chen C, Xiang Y, Liu Y, Hu X, Yang KW.

Medchemcomm. 2018 May 17;9(7):1172-1177. doi: 10.1039/c8md00091c. eCollection 2018 Jul 1.

14.

Diaryl-substituted azolylthioacetamides: Inhibitor discovery of New Delhi metallo-β-lactamase-1 (NDM-1).

Zhang YL, Yang KW, Zhou YJ, LaCuran AE, Oelschlaeger P, Crowder MW.

ChemMedChem. 2014 Nov;9(11):2445-8. doi: 10.1002/cmdc.201402249. Epub 2014 Jul 22.

PMID:
25048031
15.

N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.

Feng L, Yang KW, Zhou LS, Xiao JM, Yang X, Zhai L, Zhang YL, Crowder MW.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5185-9. doi: 10.1016/j.bmcl.2012.06.074. Epub 2012 Jul 1.

PMID:
22796180
16.

Real-Time Monitoring of NDM-1 Activity in Live Bacterial Cells by Isothermal Titration Calorimetry: A New Approach To Measure Inhibition of Antibiotic-Resistant Bacteria.

Zhang YJ, Wang WM, Oelschlaeger P, Chen C, Lei JE, Lv M, Yang KW.

ACS Infect Dis. 2018 Dec 14;4(12):1671-1678. doi: 10.1021/acsinfecdis.8b00147. Epub 2018 Nov 5.

PMID:
30383355
17.

Azolylthioacetamides as potential inhibitors of New Delhi metallo-β-lactamase-1 (NDM-1).

Liu XL, Xiang Y, Chen C, Yang KW.

J Antibiot (Tokyo). 2019 Feb;72(2):118-121. doi: 10.1038/s41429-018-0121-4. Epub 2018 Nov 19.

PMID:
30449891
18.

ML302, a Novel Beta-lactamase (BLA) Inhibitor.

Spicer T, Minond D, Enogieru I, Saldanha SA, Allais C, Liu Q, Mercer BA, Roush WR, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2014 May 13].

19.

Real-time activity assays of β-lactamases in living bacterial cells: application to the inhibition of antibiotic-resistant E. coli strains.

Ge Y, Zhou YJ, Yang KW, Zhang YL, Xiang Y, Zhang YJ.

Mol Biosyst. 2017 Oct 24;13(11):2323-2327. doi: 10.1039/c7mb00487g.

PMID:
28906528
20.

Optimization of amino acid thioesters as inhibitors of metallo-β-lactamase L1.

Liu XL, Yang KW, Zhang YJ, Ge Y, Xiang Y, Chang YN, Oelschlaeger P.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4698-4701. doi: 10.1016/j.bmcl.2016.08.048. Epub 2016 Aug 22.

PMID:
27595424

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