Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 95

1.

Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease.

Lu T, Connolly PJ, Philippar U, Sun W, Cummings MD, Barbay K, Gys L, Van Nuffel L, Austin N, Bekkers M, Shen F, Cai A, Attar R, Meerpoel L, Edwards J.

Bioorg Med Chem Lett. 2019 Dec 1;29(23):126743. doi: 10.1016/j.bmcl.2019.126743. Epub 2019 Oct 17.

PMID:
31678006
2.

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

Schlapbach A, Revesz L, Pissot Soldermann C, Zoller T, Régnier CH, Bornancin F, Radimerski T, Blank J, Schuffenhauer A, Renatus M, Erbel P, Melkko S, Heng R, Simic O, Endres R, Wartmann M, Quancard J.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2153-2158. doi: 10.1016/j.bmcl.2018.05.017. Epub 2018 May 9.

PMID:
29759726
3.

Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.

Hailfinger S, Nogai H, Pelzer C, Jaworski M, Cabalzar K, Charton JE, Guzzardi M, Décaillet C, Grau M, Dörken B, Lenz P, Lenz G, Thome M.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14596-601. doi: 10.1073/pnas.1105020108. Epub 2011 Aug 22.

4.

Peptide-based covalent inhibitors of MALT1 paracaspase.

Hatcher JM, Du G, Fontán L, Us I, Qiao Q, Chennamadhavuni S, Shao J, Wu H, Melnick A, Gray NS, Scott DA.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1336-1339. doi: 10.1016/j.bmcl.2019.03.046. Epub 2019 Mar 29.

PMID:
30954428
5.

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, Nagel D, Krappmann D, Prinz M, Beyaert R, van Loo G.

J Neuroinflammation. 2014 Jul 21;11:124. doi: 10.1186/1742-2094-11-124.

6.

Detection of recombinant and cellular MALT1 paracaspase activity.

Nagel D, Krappmann D.

Methods Mol Biol. 2015;1280:239-46. doi: 10.1007/978-1-4939-2422-6_13.

PMID:
25736752
7.

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas.

Eitelhuber AC, Vosyka O, Nagel D, Bognar M, Lenze D, Lammens K, Schlauderer F, Hlahla D, Hopfner KP, Lenz G, Hummel M, Verhelst SH, Krappmann D.

Chem Biol. 2015 Jan 22;22(1):129-38. doi: 10.1016/j.chembiol.2014.10.021. Epub 2014 Dec 31.

8.

Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.

Fontán L, Qiao Q, Hatcher JM, Casalena G, Us I, Teater M, Durant M, Du G, Xia M, Bilchuk N, Chennamadhavuni S, Palladino G, Inghirami G, Philippar U, Wu H, Scott DA, Gray NS, Melnick A.

J Clin Invest. 2018 Oct 1;128(10):4397-4412. doi: 10.1172/JCI99436. Epub 2018 Jul 19.

9.

Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors To Treat an Aggressive Subtype of Diffuse Large B-Cell Lymphoma.

Lim SM, Jeong Y, Lee S, Im H, Tae HS, Kim BG, Park HD, Park J, Hong S.

J Med Chem. 2015 Nov 12;58(21):8491-502. doi: 10.1021/acs.jmedchem.5b01415. Epub 2015 Oct 29.

PMID:
26496175
10.

Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells.

Ferch U, Kloo B, Gewies A, Pfänder V, Düwel M, Peschel C, Krappmann D, Ruland J.

J Exp Med. 2009 Oct 26;206(11):2313-20. doi: 10.1084/jem.20091167. Epub 2009 Oct 19. Erratum in: J Exp Med. 2009 Nov 23;206(12):2851.

11.

Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase.

Hailfinger S, Lenz G, Thome M.

Curr Opin Chem Biol. 2014 Dec;23:47-55. doi: 10.1016/j.cbpa.2014.09.025. Epub 2014 Oct 4. Review.

12.

MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation.

Liu W, Guo W, Hang N, Yang Y, Wu X, Shen Y, Cao J, Sun Y, Xu Q.

Oncotarget. 2016 May 24;7(21):30536-49. doi: 10.18632/oncotarget.8867.

13.

Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-κB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells.

Wu CH, Yang YH, Chen MR, Tsai CH, Cheng AL, Doong SL.

PLoS One. 2018 Jun 28;13(6):e0199779. doi: 10.1371/journal.pone.0199779. eCollection 2018.

14.

Detection and measurement of paracaspase MALT1 activity.

Hailfinger S, Pelzer C, Thome M.

Methods Mol Biol. 2014;1133:177-88. doi: 10.1007/978-1-4939-0357-3_11.

15.

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.

Bardet M, Unterreiner A, Malinverni C, Lafossas F, Vedrine C, Boesch D, Kolb Y, Kaiser D, Glück A, Schneider MA, Katopodis A, Renatus M, Simic O, Schlapbach A, Quancard J, Régnier CH, Bold G, Pissot-Soldermann C, Carballido JM, Kovarik J, Calzascia T, Bornancin F.

Immunol Cell Biol. 2018 Jan;96(1):81-99. doi: 10.1111/imcb.1018. Epub 2017 Dec 21.

PMID:
29359407
16.

Development of new Malt1 inhibitors and probes.

Xin BT, Schimmack G, Du Y, Florea BI, van der Marel GA, Driessen C, Krappmann D, Overkleeft HS.

Bioorg Med Chem. 2016 Aug 1;24(15):3312-29. doi: 10.1016/j.bmc.2016.03.035. Epub 2016 Mar 28.

PMID:
27085674
17.

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.

Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J.

Cell Rep. 2014 Nov 20;9(4):1292-305. doi: 10.1016/j.celrep.2014.10.044. Epub 2014 Nov 13.

18.

Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression.

Li Y, Huang S, Huang X, Li X, Falcon A, Soutar A, Bornancin F, Jiang Z, Xin HB, Fu M.

Cell Signal. 2018 Oct;50:1-8. doi: 10.1016/j.cellsig.2018.05.009. Epub 2018 Jun 18.

19.

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.

Pelzer C, Cabalzar K, Wolf A, Gonzalez M, Lenz G, Thome M.

Nat Immunol. 2013 Apr;14(4):337-45. doi: 10.1038/ni.2540. Epub 2013 Feb 17.

PMID:
23416615
20.

MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression.

Afonina IS, Elton L, Carpentier I, Beyaert R.

FEBS J. 2015 Sep;282(17):3286-97. doi: 10.1111/febs.13325. Epub 2015 Jun 10. Review.

Supplemental Content

Support Center