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Items: 1 to 20 of 96

1.

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.

Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ekolle Ndode-Ekane X, Levonen AL, Pitkänen A.

Int J Mol Sci. 2019 Oct 29;20(21). pii: E5395. doi: 10.3390/ijms20215395.

2.

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets.

Lipponen A, Paananen J, Puhakka N, Pitkänen A.

Sci Rep. 2016 Aug 17;6:31570. doi: 10.1038/srep31570.

3.

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury.

Lipponen A, El-Osta A, Kaspi A, Ziemann M, Khurana I, Kn H, Navarro-Ferrandis V, Puhakka N, Paananen J, Pitkänen A.

Acta Neuropathol Commun. 2018 Feb 27;6(1):17. doi: 10.1186/s40478-018-0519-z.

4.

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy.

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatillo O, Sallinen J, Ndode-Ekane XE, Pitkänen A.

Epilepsy Res. 2017 Oct;136:18-34. doi: 10.1016/j.eplepsyres.2017.07.005. Epub 2017 Jul 12.

PMID:
28753497
5.

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury.

Kumar A, Stoica BA, Loane DJ, Yang M, Abulwerdi G, Khan N, Kumar A, Thom SR, Faden AI.

J Neuroinflammation. 2017 Mar 15;14(1):47. doi: 10.1186/s12974-017-0819-4.

6.

T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury.

Ndode-Ekane XE, Matthiesen L, Bañuelos-Cabrera I, Palminha CAP, Pitkänen A.

Restor Neurol Neurosci. 2018;36(4):485-501. doi: 10.3233/RNN-170811.

PMID:
29889085
7.
8.

Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice.

Fenn AM, Skendelas JP, Moussa DN, Muccigrosso MM, Popovich PG, Lifshitz J, Eiferman DS, Godbout JP.

J Neurotrauma. 2015 Jan 15;32(2):127-38. doi: 10.1089/neu.2014.3514. Epub 2014 Nov 13.

9.

Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury.

Skovira JW, Wu J, Matyas JJ, Kumar A, Hanscom M, Kabadi SV, Fang R, Faden AI.

J Neuroinflammation. 2016 Dec 1;13(1):299.

10.

Propofol limits microglial activation after experimental brain trauma through inhibition of nicotinamide adenine dinucleotide phosphate oxidase.

Luo T, Wu J, Kabadi SV, Sabirzhanov B, Guanciale K, Hanscom M, Faden J, Cardiff K, Bengson CJ, Faden AI.

Anesthesiology. 2013 Dec;119(6):1370-88. doi: 10.1097/ALN.0000000000000020.

PMID:
24121215
11.

The neuroprotective effect of modified "Shengyu" decoction is mediated through an anti-inflammatory mechanism in the rat after traumatic brain injury.

Zhao GW, Wang Y, Li YC, Jiang ZL, Sun L, Xi X, He P, Wang GH, Xu SH, Ma DM, Ke KF.

J Ethnopharmacol. 2014;151(1):694-703. doi: 10.1016/j.jep.2013.11.041. Epub 2013 Dec 1.

PMID:
24296086
12.

Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats.

Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J.

Epilepsy Res. 2014 May;108(4):653-65. doi: 10.1016/j.eplepsyres.2014.02.001. Epub 2014 Feb 8.

PMID:
24636248
13.

Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.

Okorji UP, Velagapudi R, El-Bakoush A, Fiebich BL, Olajide OA.

Mol Neurobiol. 2016 Nov;53(9):6426-6443. doi: 10.1007/s12035-015-9543-1. Epub 2015 Nov 25.

PMID:
26607631
14.

Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification.

Wolahan SM, Hirt D, Glenn TC.

In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25.

15.

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury.

Chen X, Wu S, Chen C, Xie B, Fang Z, Hu W, Chen J, Fu H, He H.

J Neuroinflammation. 2017 Jul 24;14(1):143. doi: 10.1186/s12974-017-0917-3.

16.

Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE pathway.

Xu J, Wang H, Ding K, Zhang L, Wang C, Li T, Wei W, Lu X.

Free Radic Biol Med. 2014 Jun;71:186-95. doi: 10.1016/j.freeradbiomed.2014.03.009. Epub 2014 Mar 15.

PMID:
24642087
17.

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury.

Xu X, Yin D, Ren H, Gao W, Li F, Sun D, Wu Y, Zhou S, Lyu L, Yang M, Xiong J, Han L, Jiang R, Zhang J.

Neurobiol Dis. 2018 Sep;117:15-27. doi: 10.1016/j.nbd.2018.05.016. Epub 2018 May 30.

PMID:
29859317
18.

Previous physical exercise alters the hepatic profile of oxidative-inflammatory status and limits the secondary brain damage induced by severe traumatic brain injury in rats.

de Castro MRT, Ferreira APO, Busanello GL, da Silva LRH, da Silveira Junior MEP, Fiorin FDS, Arrifano G, Crespo-López ME, Barcelos RP, Cuevas MJ, Bresciani G, González-Gallego J, Fighera MR, Royes LFF.

J Physiol. 2017 Sep 1;595(17):6023-6044. doi: 10.1113/JP273933. Epub 2017 Jul 30.

19.

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis.

Casillas-Espinosa PM, Andrade P, Santana-Gomez C, Paananen T, Smith G, Ali I, Ciszek R, Ndode-Ekane XE, Brady RD, Tohka J, Hudson MR, Perucca P, Braine EL, Immonen R, Puhakka N, Shultz SR, Jones NC, Staba RJ, Pitkänen A, O'Brien TJ.

Epilepsy Res. 2019 Oct;156:106131. doi: 10.1016/j.eplepsyres.2019.04.011. Epub 2019 Apr 27.

PMID:
31076256
20.

Amantadine improves cognitive outcome and increases neuronal survival after fluid percussion traumatic brain injury in rats.

Wang T, Huang XJ, Van KC, Went GT, Nguyen JT, Lyeth BG.

J Neurotrauma. 2014 Feb 15;31(4):370-7. doi: 10.1089/neu.2013.2917. Epub 2013 Oct 17.

PMID:
23574258

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