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31659727,30070364,29538046,25811419,25971311,26903594,26097168,30554331,22739718,29750923,23818513,32674984,28891346,32168995,26894479,27469186,27402691,32290721,31427400,26416827,26581802,34793977,29342367,30073878,33524685,27031658,26806675,33434412,27252987,23757197,31683989,24932877,32172937,31029283,23457166,32599772,29327948,31128877,28209466,31860331,33616476,28606620,26137539,32741662,31626570,29080476,26322933,32092967,28930490,31661636,31027466,25698453,30408177,29903751,30969810,30459435,28190780,30803355,30929526,26406363,29903467,31611131,30869491,27214033,31173911,31076617,32374578,29467332,35328596,29099333,33785533,27298017,30158080,30334693,27804127,26335956,25981758,35740997,24309546,30334692,35525974,36232697,31776420,27490265,26403534,25732475,31409974,32512483,30124524,35688367,27334259,33138251,31784874,24902474,32628927,30046002,28898585,27394157,34615919,30540818,29661510,29351449,29271547,23409389,21303308,27895116,32304549,23616952,32630527,20829696,26648081,34857524,27103391,34407318,28011037,34494979,26115565,29680149,29627168,29812963,21642944,29264936,36841738,32730979,34769402,34884866,28667089,32589808,34299226,31080112,33385230,33823716,31902693,32059764,33303536,33742748,30738802,36293274,32313074,36739240,34413153,32227567,33293212,26567541,33652850,31882543,34201249,31715091,32317365,16150931,35731915,31680043,34817261,21108631,35570261,32153386,32855222,36834620,35008443,34666947,32673287,18389279,31300729,30873022,35060604,35017301,36344072,32747394,32843167,32927759,32898816,35412656,35579627,34587656,30467074,33682390,28937684,34213646,36697233,35184094,20653506,32784089,34175042,36142862,31759907,32414011,33920274,35471184,35609385,19491324,36529661,33470563,31102574,34685773,32439937,32067958,35017302,20166764,32457197,33913624,33465316,34299207,31351782,37047318,32398304,35277357,33127556,31978337,28730885,27261451,35988291,34971429,30584312,30888834,24556927,32159371,34448955,36658041,35406809,33092904,35408875,30563749,35269585,34726115,34665155,31218221,32565113,34831090,33426936,29934203,36916675,34828417,35462105,33452147,35020677,32744089,26976279,23276843,35170259,36755044,32141420,33303535,36344076,31657788,34577628,34972649,35900863,33441643,33399458,34103250,32466381,30289627,35624092,34525262,36319933,19903491,32078860,34028270,31416774,31831338,33923911,32155735,36280328,34161195,36499495,35576754,34732308,31831337,32681713,34473419,32887484,34632318,32259083,26437683,21809164,27656143,36319570,31332440,32522463,35062937,35973718,32220772,32151568,36008229,33314931,33924524,33485777,35620188,34489188,27035618,32941351,35527187,36996799,36012615,34140249,33875358,35156780,31303382,31749908,31570318,30306073,32833326,34934215,31326274,31899933,33531206,32899265,27703398,34967155,34245257,35650428,22879944,31182369,32568427,30359614,32946228,31659732,36830719,36344074,32527602,34406641,31654605,32397443,35422395,30992452,34326672,30558651,34908251,24464978,11397325,36216744,35689870,36635953,31692517,31672556,34529223,31500809,25838137,35170824,30416447,35623009,31883651,30803905,23346057,23331030,33816324,35032180,32940969,36941680,35709547,35710144,34419414,36796937,34578785,36623819,31530195,35760705,35857025,35697137,34924264,33813719,34955387,37024122,35317183,37137509,32825766,31948871,36631132,35091309,32751630,37037055,34180821,32139465,32496689,25569440,25003014,35746945,34672434,35551858,31215818,23790242,36344084,32244346,32486152,32403302,22573477,33291847,34090606,36344070,35844763,28986017,34943888,35792519,33167369,33391025,36566799,34717671,36463912,10593905,33202578,36577595,35856818,30349480,31715087,36068724,20510657,32331485,35638249,36641622,36746183,34672432,31961914,34066648,35813815,35501666,34424887,34456158,34866012,25083129,36344068,31143125,32630625,35437232,32256364,31279576,36388243,32131717,36752109,18625144,33775536,35359862,33855558,19747007,36423906,35714602,36102602,31601715,29653946,32011168,33967785,32792265,32761355,26666881,34879996,33089695,34180827,32823008,36049345,30192635,36174992,35035569,34959696,32243806,35871973,30538635,32291159,36344077,32732328,35740917,34133262,31787574,27965061,34740114,35181269,34063507,32265312,33190956,29731717,35341695,37147251,31409507,35038767,36232826,35923001,35134493,36670555,34226157,22960984,34589336,36726369,36101908,32972261,31117414,35972584,31913655,30939246,36552859,35879227,35465025,32799680,36153229,35268374,36028424,37140364,32912926,28649446,36337124,36678791,36178872,33493828,22675793,36253274,32970381,32692578,32490033,22332135,31583102,24171010,32821951,36249513,34616517,29264462,34054509,35139320,35072004,36344071,32861304,32861303,26415724,31745411,36013270,14993338,33389985,24468756,29438119,36448312,33250777,32097175,36344067,33505947,36836003,33823074,36966039,27347364,36958745,33986686,33879218,32687399,28261631,31679735,27626054,33073185,35779568,33863830,33922413,31887770,33063841,34904041,31780953,33452915,36152600,22332134,36537525,36601503,34437661,23374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Treating the Underlying Cystic Fibrosis Transmembrane Conductance Regulator Defect in Patients with Cystic Fibrosis.

Cuyx S, De Boeck K. Cuyx S, et al. Semin Respir Crit Care Med. 2019 Dec;40(6):762-774. doi: 10.1055/s-0039-1696664. Epub 2019 Oct 28. Semin Respir Crit Care Med. 2019. PMID: 31659727 Review.

Correctors (specific therapies for class II CFTR mutations) for cystic fibrosis.

Southern KW, Patel S, Sinha IP, Nevitt SJ. Southern KW, et al. Cochrane Database Syst Rev. 2018 Aug 2;8(8):CD010966. doi: 10.1002/14651858.CD010966.pub2. Cochrane Database Syst Rev. 2018. PMID: 30070364 Free PMC article. Updated. Review.

Cystic fibrosis transmembrane conductance regulator modulators: precision medicine in cystic fibrosis.

Burgener EB, Moss RB. Burgener EB, et al. Curr Opin Pediatr. 2018 Jun;30(3):372-377. doi: 10.1097/MOP.0000000000000627. Curr Opin Pediatr. 2018. PMID: 29538046 Free PMC article. Review.

Potentiators (specific therapies for class III and IV mutations) for cystic fibrosis.

Patel S, Sinha IP, Dwan K, Echevarria C, Schechter M, Southern KW. Patel S, et al. Cochrane Database Syst Rev. 2015 Mar 26;(3):CD009841. doi: 10.1002/14651858.CD009841.pub2. Cochrane Database Syst Rev. 2015. PMID: 25811419 Updated. Review.

F508del-cystic fibrosis transmembrane regulator correctors for treatment of cystic fibrosis: a patent review.

Yang H, Ma T. Yang H, et al. Expert Opin Ther Pat. 2015;25(9):991-1002. doi: 10.1517/13543776.2015.1045878. Epub 2015 May 15. Expert Opin Ther Pat. 2015. PMID: 25971311 Review.

Advancing clinical development pathways for new CFTR modulators in cystic fibrosis.

Mayer-Hamblett N, Boyle M, VanDevanter D. Mayer-Hamblett N, et al. Thorax. 2016 May;71(5):454-61. doi: 10.1136/thoraxjnl-2015-208123. Epub 2016 Feb 22. Thorax. 2016. PMID: 26903594 Free PMC article. Review.

Breakthrough therapies: Cystic fibrosis (CF) potentiators and correctors.

Solomon GM, Marshall SG, Ramsey BW, Rowe SM. Solomon GM, et al. Pediatr Pulmonol. 2015 Oct;50 Suppl 40(0 40):S3-S13. doi: 10.1002/ppul.23240. Epub 2015 Jun 19. Pediatr Pulmonol. 2015. PMID: 26097168 Free PMC article. Review.

Efficacy and Safety of CFTR Corrector and Potentiator Combination Therapy in Patients with Cystic Fibrosis for the F508del-CFTR Homozygous Mutation: A Systematic Review and Meta-analysis.

Wu HX, Zhu M, Xiong XF, Wei J, Zhuo KQ, Cheng DY. Wu HX, et al. Adv Ther. 2019 Feb;36(2):451-461. doi: 10.1007/s12325-018-0860-4. Epub 2018 Dec 15. Adv Ther. 2019. PMID: 30554331

Cystic fibrosis transmembrane conductance regulator-modifying medications: the future of cystic fibrosis treatment.

Pettit RS. Pettit RS. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1065-75. doi: 10.1345/aph.1R076. Epub 2012 Jun 26. Ann Pharmacother. 2012. PMID: 22739718 Review.

Ion Channel Modulators in Cystic Fibrosis.

Gentzsch M, Mall MA. Gentzsch M, et al. Chest. 2018 Aug;154(2):383-393. doi: 10.1016/j.chest.2018.04.036. Epub 2018 May 8. Chest. 2018. PMID: 29750923 Free PMC article. Review.

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