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Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer.

Leeman JE, Chen MH, Huland H, Graefen M, D'Amico AV, Tilki D.

Clin Genitourin Cancer. 2019 Dec;17(6):e1116-e1121. doi: 10.1016/j.clgc.2019.07.018. Epub 2019 Aug 5.


Pathological upgrading and upstaging at radical prostatectomy in Jamaican men with low-risk prostate cancer.

Morrison BF, Aiken WD, Reid G, Mayhew R, Hanchard B.

Ecancermedicalscience. 2019 Oct 29;13:971. doi: 10.3332/ecancer.2019.971. eCollection 2019.


Preoperative 3-Tesla multiparametric endorectal magnetic resonance imaging findings and the odds of upgrading and upstaging at radical prostatectomy in men with clinically localized prostate cancer.

Hegde JV, Chen MH, Mulkern RV, Fennessy FM, D'Amico AV, Tempany CM.

Int J Radiat Oncol Biol Phys. 2013 Feb 1;85(2):e101-7. doi: 10.1016/j.ijrobp.2012.08.032. Epub 2012 Oct 3.


Risk of Upgrading and Upstaging Among 10 000 Patients with Gleason 3+4 Favorable Intermediate-risk Prostate Cancer.

Yang DD, Mahal BA, Muralidhar V, Nezolosky MD, Vastola ME, Labe SA, Boldbaatar N, King MT, Martin NE, Orio PF 3rd, Beard CJ, Hoffman KE, Trinh QD, Spratt DE, Feng FY, Nguyen PL.

Eur Urol Focus. 2019 Jan;5(1):69-76. doi: 10.1016/j.euf.2017.05.011. Epub 2017 Jun 17.


Pathologic Outcomes of Gleason 6 Favorable Intermediate-Risk Prostate Cancer Treated With Radical Prostatectomy: Implications for Active Surveillance.

Yang DD, Mahal BA, Muralidhar V, Vastola ME, Boldbaatar N, Labe SA, Nezolosky MD, Orio PF 3rd, King MT, Martin NE, Mouw KW, Trinh QD, Nguyen PL.

Clin Genitourin Cancer. 2018 Jun;16(3):226-234. doi: 10.1016/j.clgc.2017.10.013. Epub 2017 Nov 9.


Racial variation in prostate cancer upgrading and upstaging among men with low-risk clinical characteristics.

Jalloh M, Myers F, Cowan JE, Carroll PR, Cooperberg MR.

Eur Urol. 2015 Mar;67(3):451-7. doi: 10.1016/j.eururo.2014.03.026. Epub 2014 Apr 5.


Utility of Gleason pattern 4 morphologies detected on transrectal ultrasound (TRUS)-guided biopsies for prediction of upgrading or upstaging in Gleason score 3 + 4 = 7 prostate cancer.

Flood TA, Schieda N, Keefe DT, Breau RH, Morash C, Hogan K, Belanger EC, Mai KT, Robertson SJ.

Virchows Arch. 2016 Sep;469(3):313-9. doi: 10.1007/s00428-016-1981-2. Epub 2016 Jul 10.


Optimizing patient selection for prostate monotherapy.

Lee AK, Schultz D, Renshaw AA, Richie JP, D'Amico AV.

Int J Radiat Oncol Biol Phys. 2001 Mar 1;49(3):673-7.


Population based study of predictors of adverse pathology among candidates for active surveillance with Gleason 6 prostate cancer.

Vellekoop A, Loeb S, Folkvaljon Y, Stattin P.

J Urol. 2014 Feb;191(2):350-7. doi: 10.1016/j.juro.2013.09.034. Epub 2013 Sep 23.


Multiparametric magnetic resonance imaging and frozen-section analysis efficiently predict upgrading, upstaging, and extraprostatic extension in patients undergoing nerve-sparing robotic-assisted radical prostatectomy.

Bianchi R, Cozzi G, Petralia G, Alessi S, Renne G, Bottero D, Brescia A, Cioffi A, Cordima G, Ferro M, Matei DV, Mazzoleni F, Musi G, Mistretta FA, Serino A, Tringali VM, Coman I, De Cobelli O.

Medicine (Baltimore). 2016 Oct;95(40):e4519.


Heterogeneity in D'Amico classification-based low-risk prostate cancer: Differences in upgrading and upstaging according to active surveillance eligibility.

Schiffmann J, Wenzel P, Salomon G, Budäus L, Schlomm T, Minner S, Wittmer C, Kraft S, Krech T, Steurer S, Sauter G, Beyer B, Boehm K, Tilki D, Michl U, Huland H, Graefen M, Karakiewicz PI.

Urol Oncol. 2015 Jul;33(7):329.e13-9. doi: 10.1016/j.urolonc.2015.04.004. Epub 2015 May 7.


Perineural invasion on biopsy is associated with upstaging at radical prostatectomy in Gleason score 3 + 4 = 7 prostate cancer.

Flood TA, Schieda N, Keefe DT, Morash C, Bateman J, Mai KT, Belanger EC, Robertson SJ, Breau RH.

Pathol Int. 2016 Nov;66(11):629-632. doi: 10.1111/pin.12467. Epub 2016 Oct 5.


Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients.

Caster JM, Falchook AD, Hendrix LH, Chen RC.

Int J Radiat Oncol Biol Phys. 2015 Jun 1;92(2):244-51. doi: 10.1016/j.ijrobp.2015.01.051. Epub 2015 Apr 1.


Upgrading and upstaging in prostate cancer: From prostate biopsy to radical prostatectomy.

D'Elia C, Cerruto MA, Cioffi A, Novella G, Cavalleri S, Artibani W.

Mol Clin Oncol. 2014 Nov;2(6):1145-1149. Epub 2014 Aug 5.


The association between prostate size and Gleason score upgrading depends on the number of biopsy cores obtained: results from the Shared Equal Access Regional Cancer Hospital Database.

Turley RS, Terris MK, Kane CJ, Aronson WJ, Presti JC Jr, Amling CL, Freedland SJ; SEARCH Database Study Group.

BJU Int. 2008 Nov;102(9):1074-9. doi: 10.1111/j.1464-410X.2008.08015.x. Epub 2008 Sep 3.


Cribriform morphology predicts upstaging after radical prostatectomy in patients with Gleason score 3 + 4 = 7 prostate cancer at transrectal ultrasound (TRUS)-guided needle biopsy.

Keefe DT, Schieda N, El Hallani S, Breau RH, Morash C, Robertson SJ, Mai KT, Belanger EC, Flood TA.

Virchows Arch. 2015 Oct;467(4):437-42. doi: 10.1007/s00428-015-1809-5. Epub 2015 Jul 31.


Predictors of unfavorable disease after radical prostatectomy in patients at low risk by D'Amico criteria: role of multiparametric magnetic resonance imaging.

Song SH, Pak S, Park S, Song C, Jeong IG, Choi HJ, Kim JK, Cho KS, Kim CS, Ahn H.

J Urol. 2014 Aug;192(2):402-8. doi: 10.1016/j.juro.2014.02.2568. Epub 2014 Mar 11.


Detailed biopsy pathologic features as predictive factors for initial reclassification in prostate cancer patients eligible for active surveillance.

Ploussard G, de la Taille A, Terry S, Allory Y, Ouzaïd I, Vacherot F, Abbou CC, Salomon L.

Urol Oncol. 2013 Oct;31(7):1060-6. doi: 10.1016/j.urolonc.2011.12.018. Epub 2012 Jan 31.


Utility of early transperineal template-guided prostate biopsy for risk stratification in men undergoing active surveillance for prostate cancer.

Voss J, Pal R, Ahmed S, Hannah M, Jaulim A, Walton T.

BJU Int. 2018 Jun;121(6):863-870. doi: 10.1111/bju.14100. Epub 2018 Jan 17.


Incidence of upgrading and upstaging in patients with low-volume Gleason score 3+4 prostate cancers at biopsy: finding a new group eligible for active surveillance.

Park HJ, Ha YS, Park SY, Kim YT, Lee TY, Kim JH, Lee DH, Kim WJ, Kim IY.

Urol Int. 2013;90(3):301-5. doi: 10.1159/000345292. Epub 2013 Feb 5.


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