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31545263,29241031,31373750,33558888,26070954,31254953,25887269,27036629,31520992,31210339,29510084,29324628,27959396,33140555,34737012,35882782,34747306,31698051,24916807,20805679,26272311,26211495,26540118,24818579,28638921,19386282,23656768,30475328,23747643,18718124,30691855,26507165,27470389,31243816,33872850,30203548,26800098,28365871,25399896,27347929,30584668,29312480,21640201,33641076,26321117,30645708,25875290,31001923,35793597,30838705,30864740,28711783,26956470,31255931,27262946,28656298,24161915,28031043,29199874,32926510,30231673,22508291,31306981,31419076,29545877,31784404,34212053,33350272,28129682,30807930,25577143,26921732,26481965,30661349,36555773,25861954,30521962,28204830,31912804,25102245,21875662,25676436,29975331,28483599,30006502,28192201,28368327,35063752,35026506,30986645,30659917,35449859,33389901,31154727,31520990,33639054,27104958,36055546,36845637,34676874,26363199,25620130,35764933,26721707,35014685,31931639,31353880,22835426,25841318,33173983,28600744,27395046,33383282,35976115,27109786,26832323,31486847,36183949,30013022,25835778,29687869,34112289,24534526,32045770,28886315,32705282,36182735,26138418,26468152,36583372,25902336,31576113,26782291,25660288,28724884,27620503,26648090,23651796,31429423,22683864,29704150,25480515,31927655,22931982,23751215,34955133,25476077,31631367,35533916,30403294,21939782,32468034,24345260,33949057,35738472,31506998,31274341,36075570,28972887,35863724,34464887,32798558,35874106,30779099,34516310,29438223,33360370,36934667,32750045,34426780,32522221,36150645,31726235,33187816,23180366,31358372,30134043,25519986,32706450,34498273,31883915,32950633,34951223,36567560,22968433,33662817,30118542,33185125,25008149,31991373,25347274,33857805,34608599,34634688,30091835,32855724,35551994,24566873,33323555,33617946,36242967,32377532,33000200,36040529,31218570,33182056,35912428,24748477,31466050,34467464,33392621,35002723,24345905,22466397,36036101,24487736,31494298,32725973,36842235,36046440,29359143,24278171,37139806,32845434,32038265,32626914,31802426,32130427,34427852,30937316,32234670,36587557,32787359,23437127,33930521,36724020,32705267,35537248,35178922,31242025,35142579,32855531,24085645,24058610,30657579,29438224,32419528,20302656,25752620,32929324,33109608,35605218,29359990,31210324,26884836,31186277,30028919,34243622,33660822,31179071,36640559,22198681,25005005,34863997,32044659,31694415,34865994,31588189,31678237,31208297,33729131,36504132,36047729,32627922,31682847,31440860,35284551,34806444,33490163,31773760,32915230,34942323,28624894,34988180,32607919,25269519,25387673,32018220,33275257,24928630,33039959,33961853,35028666,30884345,33383130,32932915,36705406,23690665,33774062,34783223,31693211,33880584,37052973,32581788,36566563,35933468,35012919,27928219,22744777,31248593,31631971,31865141,36116250,34162568,34602563,36116199,36028178,34298401,36846195,32036210,31389589,33821300,34812690,32972060,32170603,36882272,23623941,35545320,30951719,24387839,35616142,18292749,35034883,34581091,28801798,33633565,36610129,31489801,25214712,35473340,34160729,32788013,24229378,35305560,37080368,25097454,36252879,27175331,35182669,33577850,30627552,33383446,30600796,27302421,33751359,35078570,33495514,34807349,35059042,28188225,29545858,35112986,33850093,32033557,22959885,32079441,29621734,31004869,34308863,24425537,33141376,22101700,35319164,32084579,34703269,35418745,34811808,28043040,33649807,30618065,31538519,31478596,33848686,31860763,22563684,31395340,34114328,33774474,26152793,36047892,31931370,26432864,23199346,35599418,32440780,32265704,25866535,31676364,31847115,35514783,31696351,36764283,22092133,23846716,34280918,31805278,25844689,35026488,29285127,34040072,31389587,36362264,23053725,32735017,24244013,25483737,35967416,35836757,32170527,33179083,34908806,36350972,32441737,32071922,24958013,32152924,32707303,34472624,31926447,35588105,34806822,32889238,31974595,32034118,20017955,32533502,23082119,33182051,31254764,26573555,37101633,36105322,32680981,26171152,32090080,23874764,23271190,30362554,31425874,27168812,35488217,31595149,33229758,36738242,20387088,29488614,30919976,35428330,21473879,22219049,35938963,23354246,31949658,31815144,19324974,36150463,31624922,33382969,26852688,33223957,25243152,20452617,23532269,31487506,31680664,31295064,31366881,34874520,32649510,28812176,33046059,30861187,35278280,35486975,36700766,26190353,29619068,35770920,22772811,29179596,34223915,24849134,36804541,35985062,34250720,35240239,31581526,30771687,31611929,32016469,34480112,25022445,31297873,35421429,35392150,32712064,37036635,32110933,32967743,33719658,34852453,26097529,32003008,35153740,34363182,33255656,34887746,32415933,17088249,34637694,35123988,30587929,31611735,31210336,33569375,21330948,33771723,35696803,36177927,35483561,34063554,34447467,35531876,30808956,30760290,37024954,33625944,31639817,35992691,34366849,18077459,36655330,34638032,23071799,31281454,36039902,31553308,30913929,36162226,33300078,32655771,35485217,36193122,33355369,32147387,31272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Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury in rats by inhibition of caveolin-1 downstream signaling.

Liu J, Huang X, Hu S, He H, Meng Z. Liu J, et al. Biomed Pharmacother. 2019 Oct;118:109314. doi: 10.1016/j.biopha.2019.109314. Epub 2019 Aug 10. Biomed Pharmacother. 2019. PMID: 31545263 Free article.

The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways.

Meng L, Li L, Lu S, Li K, Su Z, Wang Y, Fan X, Li X, Zhao G. Meng L, et al. Mol Immunol. 2018 Feb;94:7-17. doi: 10.1016/j.molimm.2017.12.008. Epub 2017 Dec 11. Mol Immunol. 2018. PMID: 29241031

Dexmedetomidine protects against lung injury induced by limb ischemia-reperfusion via the TLR4/MyD88/NF-κB pathway.

Xue BB, Chen BH, Tang YN, Weng CW, Lin LN. Xue BB, et al. Kaohsiung J Med Sci. 2019 Nov;35(11):672-678. doi: 10.1002/kjm2.12115. Epub 2019 Aug 2. Kaohsiung J Med Sci. 2019. PMID: 31373750 Free article.

Dexmedetomidine attenuates lipopolysaccharide-induced acute liver injury in rats by inhibiting caveolin-1 downstream signaling pathway.

Tong F, Shen W, Song P, Song J, Hu Y, Liu F, Meng Z, Liu J. Tong F, et al. Biosci Rep. 2021 Mar 26;41(3):BSR20204279. doi: 10.1042/BSR20204279. Biosci Rep. 2021. PMID: 33558888 Free PMC article.

Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4-nuclear factor kappa B signaling.

Chi X, Wei X, Gao W, Guan J, Yu X, Wang Y, Li X, Cai J. Chi X, et al. J Transl Med. 2015 Jun 13;13:190. doi: 10.1186/s12967-015-0554-5. J Transl Med. 2015. PMID: 26070954 Free PMC article.

Dexmedetomidine ameliorates LPS induced acute lung injury via GSK-3β/STAT3-NF-κB signaling pathway in rats.

Zhang H, Sha J, Feng X, Hu X, Chen Y, Li B, Fan H. Zhang H, et al. Int Immunopharmacol. 2019 Sep;74:105717. doi: 10.1016/j.intimp.2019.105717. Epub 2019 Jun 26. Int Immunopharmacol. 2019. PMID: 31254953

Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4/NF-kappaB pathway.

Feng G, Sun B, Li TZ. Feng G, et al. Int Immunopharmacol. 2015 Jun;26(2):392-400. doi: 10.1016/j.intimp.2015.04.002. Epub 2015 Apr 15. Int Immunopharmacol. 2015. PMID: 25887269

Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-κB signaling pathway and MMP-9 expression.

Zhang X, Sun CY, Zhang YB, Guo HZ, Feng XX, Peng SZ, Yuan J, Zheng RB, Chen WP, Su ZR, Huang XD. Zhang X, et al. J Ethnopharmacol. 2016 Jun 20;186:91-102. doi: 10.1016/j.jep.2016.03.057. Epub 2016 Mar 30. J Ethnopharmacol. 2016. PMID: 27036629

Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF-κB signaling downregulation partly via cholinergic anti-inflammatory mechanisms.

Zi SF, Li JH, Liu L, Deng C, Ao X, Chen DD, Wu SZ. Zi SF, et al. Int Immunopharmacol. 2019 Nov;76:105898. doi: 10.1016/j.intimp.2019.105898. Epub 2019 Sep 11. Int Immunopharmacol. 2019. PMID: 31520992

Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway.

Jin YH, Li ZT, Chen H, Jiang XQ, Zhang YY, Wu F. Jin YH, et al. Eur Rev Med Pharmacol Sci. 2019 Jun;23(11):5020-5025. doi: 10.26355/eurrev_201906_18094. Eur Rev Med Pharmacol Sci. 2019. PMID: 31210339 Free article.

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