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A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor.

Tan S, Li W, Li Z, Li Y, Luo J, Yu L, Yang J, Qiu M, Cheng H, Xu W, Jiang S, Lu L, Liu S, Ma W.

Viruses. 2019 Sep 18;11(9). pii: E874. doi: 10.3390/v11090874.


Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycans.

Valenzuela-Fernández A, Palanche T, Amara A, Magerus A, Altmeyer R, Delaunay T, Virelizier JL, Baleux F, Galzi JL, Arenzana-Seisdedos F.

J Biol Chem. 2001 Jul 13;276(28):26550-8. Epub 2001 May 14.


The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states.

Di Salvo J, Koch GE, Johnson KE, Blake AD, Daugherty BL, DeMartino JA, Sirotina-Meisher A, Liu Y, Springer MS, Cascieri MA, Sullivan KA.

Eur J Pharmacol. 2000 Dec 8;409(2):143-54.


Human CD34(+) cells express CXCR4 and its ligand stromal cell-derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus.

Aiuti A, Turchetto L, Cota M, Cipponi A, Brambilla A, Arcelloni C, Paroni R, Vicenzi E, Bordignon C, Poli G.

Blood. 1999 Jul 1;94(1):62-73.


HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication.

Amara A, Gall SL, Schwartz O, Salamero J, Montes M, Loetscher P, Baggiolini M, Virelizier JL, Arenzana-Seisdedos F.

J Exp Med. 1997 Jul 7;186(1):139-46.


Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.

Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, Marsh M.

J Cell Biol. 1997 Nov 3;139(3):651-64.


Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1α probed by a novel synthetically and modularly modified-chemokine analog.

Dong CZ, Tian S, Madani N, Choi WT, Kumar S, Liu D, Sodroski JG, Huang Z, An J.

Exp Biol Med (Maywood). 2011 Dec;236(12):1413-9. doi: 10.1258/ebm.2011.011260. Epub 2011 Nov 18.


Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides.

Heveker N, Montes M, Germeroth L, Amara A, Trautmann A, Alizon M, Schneider-Mergener J.

Curr Biol. 1998 Mar 26;8(7):369-76.


Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies.

Zhou N, Luo Z, Luo J, Liu D, Hall JW, Pomerantz RJ, Huang Z.

J Biol Chem. 2001 Nov 16;276(46):42826-33. Epub 2001 Sep 10.


HIV co-receptors as targets for antiviral therapy.

Schols D.

Curr Top Med Chem. 2004;4(9):883-93. Review.


The CXC chemokine stromal cell-derived factor 1 is not responsible for CD8+ T cell suppression of syncytia-inducing strains of HIV-1.

Lacey SF, McDanal CB, Horuk R, Greenberg ML.

Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9842-7.


The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor.

Mosi RM, Anastassova V, Cox J, Darkes MC, Idzan SR, Labrecque J, Lau G, Nelson KL, Patel K, Santucci Z, Wong RS, Skerlj RT, Bridger GJ, Huskens D, Schols D, Fricker SP.

Biochem Pharmacol. 2012 Feb 15;83(4):472-9. doi: 10.1016/j.bcp.2011.11.020. Epub 2011 Nov 28.


Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist.

Jenkinson S, Thomson M, McCoy D, Edelstein M, Danehower S, Lawrence W, Wheelan P, Spaltenstein A, Gudmundsson K.

Antimicrob Agents Chemother. 2010 Feb;54(2):817-24. doi: 10.1128/AAC.01293-09. Epub 2009 Nov 30.


Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin.

Pablos JL, Amara A, Bouloc A, Santiago B, Caruz A, Galindo M, Delaunay T, Virelizier JL, Arenzana-Seisdedos F.

Am J Pathol. 1999 Nov;155(5):1577-86.


Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization.

Orsini MJ, Parent JL, Mundell SJ, Marchese A, Benovic JL.

J Biol Chem. 1999 Oct 22;274(43):31076-86. Erratum in: J Biol Chem 2000 Aug 18;275(33):25876. Marchese, Adriano [added].

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