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Items: 1 to 20 of 91


One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer.

Yang F, Xiao W, Liu Y, Liu R, Kramer R, Li X, Ajena Y, Baehr CM, Rojalin T, Zhang H, Lam KS.

Oncotarget. 2019 Sep 10;10(52):5468-5479. doi: 10.18632/oncotarget.27189. eCollection 2019 Sep 10.


Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors.

Xiao W, Li T, Bononi FC, Lac D, Kekessie IA, Liu Y, Sanchez E, Mazloom A, Ma AH, Lin J, Tran J, Yang K, Lam KS, Liu R.

EJNMMI Res. 2016 Dec;6(1):18. doi: 10.1186/s13550-016-0165-z. Epub 2016 Feb 27.


Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method.

Yao N, Xiao W, Wang X, Marik J, Park SH, Takada Y, Lam KS.

J Med Chem. 2009 Jan 8;52(1):126-33. doi: 10.1021/jm801062d.


From combinatorial chemistry to cancer-targeting peptides.

Aina OH, Liu R, Sutcliffe JL, Marik J, Pan CX, Lam KS.

Mol Pharm. 2007 Sep-Oct;4(5):631-51. Epub 2007 Sep 20. Review.


Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting alpha 3 integrin.

Xiao W, Yao N, Peng L, Liu R, Lam KS.

Eur J Nucl Med Mol Imaging. 2009 Jan;36(1):94-103. doi: 10.1007/s00259-008-0920-0. Epub 2008 Aug 19.


Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics.

Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS.

J Calif Dent Assoc. 2012 Dec;40(12):939-43.


Tumor-targeting peptides from combinatorial libraries.

Liu R, Li X, Xiao W, Lam KS.

Adv Drug Deliv Rev. 2017 Feb;110-111:13-37. doi: 10.1016/j.addr.2016.05.009. Epub 2016 May 19. Review. Erratum in: Adv Drug Deliv Rev. 2018 Mar 9;:.


Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach.

Zhang H, Aina OH, Lam KS, de Vere White R, Evans C, Henderson P, Lara PN, Wang X, Bassuk JA, Pan CX.

Urol Oncol. 2012 Sep;30(5):635-45. doi: 10.1016/j.urolonc.2010.06.011. Epub 2010 Oct 2.


Near-infrared optical imaging of ovarian cancer xenografts with novel alpha 3-integrin binding peptide "OA02".

Aina OH, Marik J, Gandour-Edwards R, Lam KS.

Mol Imaging. 2005 Oct-Dec;4(4):439-47.


High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer.

Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T.

J Hematol Oncol. 2019 Jun 10;12(1):56. doi: 10.1186/s13045-019-0740-7. Erratum in: J Hematol Oncol. 2019 Jul 26;12(1):83.


Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods.

Kumaresan PR, Wang Y, Saunders M, Maeda Y, Liu R, Wang X, Lam KS.

ACS Comb Sci. 2011 May 9;13(3):259-64. doi: 10.1021/co100069t. Epub 2011 Feb 8.


Oxysophocarpine Retards the Growth and Metastasis of Oral Squamous Cell Carcinoma by Targeting the Nrf2/HO-1 Axis.

Liu R, Peng J, Wang H, Li L, Wen X, Tan Y, Zhang L, Wan H, Chen F, Nie X.

Cell Physiol Biochem. 2018;49(5):1717-1733. doi: 10.1159/000493615. Epub 2018 Sep 19.


High-throughput screening of one-bead-one-compound peptide libraries using intact cells.

Cho CF, Behnam Azad B, Luyt LG, Lewis JD.

ACS Comb Sci. 2013 Aug 12;15(8):393-400. doi: 10.1021/co4000584. Epub 2013 Jul 19.


Applications of topologically segregated bilayer beads in 'one-bead one-compound' combinatorial libraries.

Wang X, Peng L, Liu R, Xu B, Lam KS.

J Pept Res. 2005 Jan;65(1):130-8.


Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries.

Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE.

ACS Comb Sci. 2016 Jun 13;18(6):271-8. doi: 10.1021/acscombsci.5b00180. Epub 2016 May 23.


Encoding method for OBOC small molecule libraries using a biphasic approach for ladder-synthesis of coding tags.

Wang X, Zhang J, Song A, Lebrilla CB, Lam KS.

J Am Chem Soc. 2004 May 12;126(18):5740-9.


On-bead screening of combinatorial libraries: reduction of nonspecific binding by decreasing surface ligand density.

Chen X, Tan PH, Zhang Y, Pei D.

J Comb Chem. 2009 Jul-Aug;11(4):604-11. doi: 10.1021/cc9000168.

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