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Items: 1 to 20 of 98

1.

Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis.

Wang Q, Onuma K, Liu C, Wong H, Bloom MS, Elliott EE, Cao RR, Hu N, Lingampalli N, Sharpe O, Zhao X, Sohn DH, Lepus CM, Sokolove J, Mao R, Cisar CT, Raghu H, Chu CR, Giori NJ, Willingham SB, Prohaska SS, Cheng Z, Weissman IL, Robinson WH.

JCI Insight. 2019 Sep 19;4(18). pii: 128616. doi: 10.1172/jci.insight.128616.

2.

IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis.

Wang Q, Lepus CM, Raghu H, Reber LL, Tsai MM, Wong HH, von Kaeppler E, Lingampalli N, Bloom MS, Hu N, Elliott EE, Oliviero F, Punzi L, Giori NJ, Goodman SB, Chu CR, Sokolove J, Fukuoka Y, Schwartz LB, Galli SJ, Robinson WH.

Elife. 2019 May 14;8. pii: e39905. doi: 10.7554/eLife.39905.

3.

Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis.

Garciadiego-Cázares D, Aguirre-Sánchez HI, Abarca-Buis RF, Kouri JB, Velasquillo C, Ibarra C.

PLoS One. 2015 May 26;10(5):e0127166. doi: 10.1371/journal.pone.0127166. eCollection 2015.

4.

Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways.

Filla MS, Schwinn MK, Sheibani N, Kaufman PL, Peters DM.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5723-31. doi: 10.1167/iovs.08-3215. Epub 2009 Jul 30.

5.

RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.

Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ.

Arthritis Rheum. 2013 Oct;65(10):2623-33. doi: 10.1002/art.38076.

6.

Immune modulation to improve tissue engineering outcomes for cartilage repair in the osteoarthritic joint.

Fahy N, Farrell E, Ritter T, Ryan AE, Murphy JM.

Tissue Eng Part B Rev. 2015 Feb;21(1):55-66. doi: 10.1089/ten.TEB.2014.0098. Epub 2014 Aug 4. Review.

7.

Molecular regulation of articular chondrocyte function and its significance in osteoarthritis.

Schroeppel JP, Crist JD, Anderson HC, Wang J.

Histol Histopathol. 2011 Mar;26(3):377-94. doi: 10.14670/HH-26.377. Review.

PMID:
21210351
8.

CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model.

Orazizadeh M, Lee HS, Groenendijk B, Sadler SJ, Wright MO, Lindberg FP, Salter DM.

Arthritis Res Ther. 2008;10(1):R4. doi: 10.1186/ar2350. Epub 2008 Jan 10.

9.

Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin.

Rock MJ, Holden P, Horton WA, Cohn DH.

Mol Cell Biochem. 2010 May;338(1-2):215-24. doi: 10.1007/s11010-009-0355-3. Epub 2009 Dec 24.

10.

Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.

Ko JY, Sun YC, Li WC, Wang FS.

J Mol Med (Berl). 2016 Jul;94(7):755-69. doi: 10.1007/s00109-016-1422-3. Epub 2016 Apr 27.

PMID:
27118120
11.

Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis.

Bradley EW, Carpio LR, McGee-Lawrence ME, Castillejo Becerra C, Amanatullah DF, Ta LE, Otero M, Goldring MB, Kakar S, Westendorf JJ.

Osteoarthritis Cartilage. 2016 Jun;24(6):1021-8. doi: 10.1016/j.joca.2015.12.014. Epub 2015 Dec 31.

12.

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction.

Ryu JH, Shin Y, Huh YH, Yang S, Chun CH, Chun JS.

Cell Death Differ. 2012 Mar;19(3):440-50. doi: 10.1038/cdd.2011.111. Epub 2011 Aug 26.

13.

Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets.

de Kroon LMG, van den Akker GGH, Brachvogel B, Narcisi R, Belluoccio D, Jenner F, Bateman JF, Little CB, Brama PAJ, Blaney Davidson EN, van der Kraan PM, van Osch GJVM.

Bone. 2018 Nov;116:67-77. doi: 10.1016/j.bone.2018.07.008. Epub 2018 Jul 21.

PMID:
30010080
14.

Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints.

Candela ME, Wang C, Gunawardena AT, Zhang K, Cantley L, Yasuhara R, Usami Y, Francois N, Iwamoto M, van der Flier A, Zhang Y, Qin L, Han L, Enomoto-Iwamoto M.

PLoS One. 2016 Jun 9;11(6):e0156783. doi: 10.1371/journal.pone.0156783. eCollection 2016.

15.

Anticytokine therapy for osteoarthritis: evidence to date.

Malemud CJ.

Drugs Aging. 2010 Feb 1;27(2):95-115. doi: 10.2165/11319950-000000000-00000.

PMID:
20104937
16.

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis.

Hwang HS, Kim HA.

Int J Mol Sci. 2015 Oct 30;16(11):26035-54. doi: 10.3390/ijms161125943. Review.

17.

Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling.

Wang PE, Zhang L, Ying J, Jin X, Luo C, Xu S, Dong R, Xiao L, Tong P, Jin H.

J Transl Med. 2018 Mar 20;16(1):72. doi: 10.1186/s12967-018-1437-3.

18.

CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts.

Hou SM, Hou CH, Liu JF.

Arthritis Res Ther. 2017 Dec 21;19(1):282. doi: 10.1186/s13075-017-1487-6.

19.

The role of cytokines in osteoarthritis pathophysiology.

Fernandes JC, Martel-Pelletier J, Pelletier JP.

Biorheology. 2002;39(1-2):237-46. Review.

PMID:
12082286
20.

Role of integrins and their ligands in osteoarthritic cartilage.

Tian J, Zhang FJ, Lei GH.

Rheumatol Int. 2015 May;35(5):787-98. doi: 10.1007/s00296-014-3137-5. Epub 2014 Sep 27. Review.

PMID:
25261047

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