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Items: 1 to 20 of 97

1.

TCR-pMHC bond conformation controls TCR ligand discrimination.

Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J.

Cell Mol Immunol. 2019 Sep 17. doi: 10.1038/s41423-019-0273-6. [Epub ahead of print]

PMID:
31530899
2.

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

Huppa JB, Axmann M, Mörtelmaier MA, Lillemeier BF, Newell EW, Brameshuber M, Klein LO, Schütz GJ, Davis MM.

Nature. 2010 Feb 18;463(7283):963-7. doi: 10.1038/nature08746.

3.

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay.

Axmann M, Schütz GJ, Huppa JB.

J Vis Exp. 2015 Oct 30;(105):e53157. doi: 10.3791/53157.

4.

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC.

Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017.

5.

TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding.

Limozin L, Bridge M, Bongrand P, Dushek O, van der Merwe PA, Robert P.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16943-16948. doi: 10.1073/pnas.1902141116. Epub 2019 Jul 17.

PMID:
31315981
6.

Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.

Pielak RM, O'Donoghue GP, Lin JJ, Alfieri KN, Fay NC, Low-Nam ST, Groves JT.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12190-12195. doi: 10.1073/pnas.1613140114. Epub 2017 Oct 30.

7.

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination.

Brazin KN, Mallis RJ, Das DK, Feng Y, Hwang W, Wang JH, Wagner G, Lang MJ, Reinherz EL.

Front Immunol. 2015 Sep 3;6:441. doi: 10.3389/fimmu.2015.00441. eCollection 2015. Review.

8.

Structural and biophysical insights into the role of CD4 and CD8 in T cell activation.

Li Y, Yin Y, Mariuzza RA.

Front Immunol. 2013 Jul 22;4:206. doi: 10.3389/fimmu.2013.00206. eCollection 2013.

9.

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.

Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1517-22. doi: 10.1073/pnas.1424829112. Epub 2015 Jan 20.

10.

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells.

O'Donoghue GP, Pielak RM, Smoligovets AA, Lin JJ, Groves JT.

Elife. 2013 Jul 3;2:e00778. doi: 10.7554/eLife.00778.

11.

Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition.

Wu P, Zhang T, Liu B, Fei P, Cui L, Qin R, Zhu H, Yao D, Martinez RJ, Hu W, An C, Zhang Y, Liu J, Shi J, Fan J, Yin W, Sun J, Zhou C, Zeng X, Xu C, Wang J, Evavold BD, Zhu C, Chen W, Lou J.

Mol Cell. 2019 Mar 7;73(5):1015-1027.e7. doi: 10.1016/j.molcel.2018.12.018. Epub 2019 Jan 30.

PMID:
30711376
12.

The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex.

Glassman CR, Parrish HL, Deshpande NR, Kuhns MS.

J Immunol. 2016 Jun 1;196(11):4713-22. doi: 10.4049/jimmunol.1502110. Epub 2016 May 2.

13.

Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.

Hong J, Persaud SP, Horvath S, Allen PM, Evavold BD, Zhu C.

J Immunol. 2015 Oct 15;195(8):3557-64. doi: 10.4049/jimmunol.1501407. Epub 2015 Sep 2.

14.

Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites.

Rangarajan S, He Y, Chen Y, Kerzic MC, Ma B, Gowthaman R, Pierce BG, Nussinov R, Mariuzza RA, Orban J.

J Biol Chem. 2018 Oct 12;293(41):15991-16005. doi: 10.1074/jbc.RA118.003832. Epub 2018 Aug 22.

15.

T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

Choudhuri K, Wiseman D, Brown MH, Gould K, van der Merwe PA.

Nature. 2005 Jul 28;436(7050):578-82.

PMID:
16049493
16.

Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells.

Williams CM, Schonnesen AA, Zhang SQ, Ma KY, He C, Yamamoto T, Eckhardt SG, Klebanoff CA, Jiang N.

Front Immunol. 2017 Jul 28;8:894. doi: 10.3389/fimmu.2017.00894. eCollection 2017.

17.

CD8 kinetically promotes ligand binding to the T-cell antigen receptor.

Gakamsky DM, Luescher IF, Pramanik A, Kopito RB, Lemonnier F, Vogel H, Rigler R, Pecht I.

Biophys J. 2005 Sep;89(3):2121-33. Epub 2005 Jun 24.

18.

TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility.

Hawse WF, De S, Greenwood AI, Nicholson LK, Zajicek J, Kovrigin EL, Kranz DM, Garcia KC, Baker BM.

J Immunol. 2014 Mar 15;192(6):2885-91. doi: 10.4049/jimmunol.1302953. Epub 2014 Feb 12.

19.

Structural basis for self-recognition by autoimmune T-cell receptors.

Yin Y, Li Y, Mariuzza RA.

Immunol Rev. 2012 Nov;250(1):32-48. doi: 10.1111/imr.12002. Review.

PMID:
23046121
20.

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

Jönsson P, Southcombe JH, Santos AM, Huo J, Fernandes RA, McColl J, Lever M, Evans EJ, Hudson A, Chang VT, Hanke T, Godkin A, Dunne PD, Horrocks MH, Palayret M, Screaton GR, Petersen J, Rossjohn J, Fugger L, Dushek O, Xu XN, Davis SJ, Klenerman D.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5682-7. doi: 10.1073/pnas.1513918113. Epub 2016 Apr 25.

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