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Items: 1 to 20 of 100

1.

The mechanism of Oatp1a5-mediated microcystin-leucine arginine entering into GnRH neurons.

Jin H, Wang B, Hou J, Ma T, Qiao D, Miao Y, Ding J, Han X.

Ecotoxicol Environ Saf. 2019 Nov 30;184:109614. doi: 10.1016/j.ecoenv.2019.109614. Epub 2019 Sep 14.

PMID:
31526925
2.

The organic anion transporting polypeptide 1a5 is a pivotal transporter for the uptake of microcystin-LR by gonadotropin-releasing hormone neurons.

Ding J, Wang J, Xiang Z, Diao W, Su M, Shi W, Wan T, Han X.

Aquat Toxicol. 2017 Jan;182:1-10. doi: 10.1016/j.aquatox.2016.11.005. Epub 2016 Nov 9.

PMID:
27842270
3.

Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus.

Wang J, Chen Y, Chen Z, Xiang Z, Ding J, Han X.

Ecotoxicol Environ Saf. 2018 Nov 15;163:391-399. doi: 10.1016/j.ecoenv.2018.07.094. Epub 2018 Jul 29.

PMID:
30064084
4.

Microcystin-LR causes sexual hormone disturbance in male rat by targeting gonadotropin-releasing hormone neurons.

Wang X, Ding J, Xiang Z, Jiang P, Du J, Han X.

Toxicon. 2016 Dec 1;123:45-55. doi: 10.1016/j.toxicon.2016.10.011. Epub 2016 Oct 20.

PMID:
27773737
5.

Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice.

Ding J, Wang J, Jin H, Xia T, Cheng Y, Wu J, Han X.

Sci Total Environ. 2018 Dec 1;643:496-506. doi: 10.1016/j.scitotenv.2018.06.123. Epub 2018 Jun 23.

PMID:
29945085
6.

The toxic effects of microcystin-LR on rat spermatogonia in vitro.

Zhou Y, Yuan J, Wu J, Han X.

Toxicol Lett. 2012 Jul 7;212(1):48-56. doi: 10.1016/j.toxlet.2012.05.001. Epub 2012 May 10.

PMID:
22579952
7.

Effect of cyanotoxins on the hypothalamic-pituitary-gonadal axis in male adult mouse.

Xiong X, Zhong A, Xu H.

PLoS One. 2014 Nov 6;9(11):e106585. doi: 10.1371/journal.pone.0106585. eCollection 2014.

8.

A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity.

Meng X, Peng H, Ding Y, Zhang L, Yang J, Han X.

Sci Total Environ. 2019 Jun 1;667:563-577. doi: 10.1016/j.scitotenv.2019.02.393. Epub 2019 Feb 28.

PMID:
30833255
9.

From the Cover: Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis.

Zhang L, Meng X, Xiang Z, Li D, Han X.

Toxicol Sci. 2018 Jan 1;161(1):159-170. doi: 10.1093/toxsci/kfx209.

PMID:
29040791
10.

Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels.

Chen Y, Wang J, Chen X, Li D, Han X.

Aquat Toxicol. 2018 Jun;199:116-126. doi: 10.1016/j.aquatox.2018.03.018. Epub 2018 Mar 17.

PMID:
29621671
11.

Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring.

Zhang L, Zhang H, Zhang H, Benson M, Han X, Li D.

Food Chem Toxicol. 2017 Jul;105:177-185. doi: 10.1016/j.fct.2017.04.014. Epub 2017 Apr 13.

PMID:
28414124
12.

Comparative effects of nodularin and microcystin-LR in zebrafish: 1. Uptake by organic anion transporting polypeptide Oatp1d1 (Slco1d1).

Faltermann S, Prétôt R, Pernthaler J, Fent K.

Aquat Toxicol. 2016 Feb;171:69-76. doi: 10.1016/j.aquatox.2015.11.016.

PMID:
26769064
13.

Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis.

Chen Y, Wang J, Zhang Q, Xiang Z, Li D, Han X.

Environ Pollut. 2017 Oct;229:964-975. doi: 10.1016/j.envpol.2017.07.081. Epub 2017 Jul 29.

PMID:
28765008
14.

Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats.

Tani T, Gram LK, Arakawa H, Kikuchi A, Chiba M, Ishii Y, Steffansen B, Tamai I.

Pharm Res. 2008 May;25(5):1085-91. Epub 2007 Oct 24.

PMID:
17957449
15.

Microcystin (-LR) affects hormones level of male mice by damaging hypothalamic-pituitary system.

Wang X, Ying F, Chen Y, Han X.

Toxicon. 2012 Feb;59(2):205-14. doi: 10.1016/j.toxicon.2011.12.001. Epub 2011 Dec 8.

PMID:
22178782
16.

Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia.

Pan C, Chen Y, Xu T, Wang J, Li D, Han X.

Environ Pollut. 2018 Nov;242(Pt B):1535-1545. doi: 10.1016/j.envpol.2018.08.024. Epub 2018 Aug 17.

PMID:
30145517
17.

Microcystin-leucine-arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8.

Chen Y, Wang J, Pan C, Li D, Han X.

Cell Mol Life Sci. 2018 Mar;75(6):1117-1132. doi: 10.1007/s00018-017-2687-6. Epub 2017 Oct 25.

PMID:
29071384
18.

Microcystin-LR induced liver injury in mice and in primary human hepatocytes is caused by oncotic necrosis.

Woolbright BL, Williams CD, Ni H, Kumer SC, Schmitt T, Kane B, Jaeschke H.

Toxicon. 2017 Jan;125:99-109. doi: 10.1016/j.toxicon.2016.11.254. Epub 2016 Nov 23.

19.

Single and combined exposure of microcystin-LR and nitrite results in reproductive endocrine disruption via hypothalamic-pituitary-gonadal-liver axis.

Lin W, Guo H, Li Y, Wang L, Zhang D, Hou J, Wu X, Li L, Li D, Zhang X.

Chemosphere. 2018 Nov;211:1137-1146. doi: 10.1016/j.chemosphere.2018.08.049. Epub 2018 Aug 13.

PMID:
30223329
20.

Resveratrol Ameliorates Microcystin-LR-Induced Testis Germ Cell Apoptosis in Rats via SIRT1 Signaling Pathway Activation.

Liu H, Zhang S, Liu C, Wu J, Wang Y, Yuan L, Du X, Wang R, Marwa PW, Zhuang D, Cheng X, Zhang H.

Toxins (Basel). 2018 Jun 9;10(6). pii: E235. doi: 10.3390/toxins10060235.

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