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Thioredoxin-interacting Protein (TXNIP) Mediates Thioredoxin-dependent Antioxidant Mechanism in Endometrial Cancer Cells Treated With 1α,25-dihydroxyvitamin D3.

Kim Y, Kim YS, Kim M, Kim JM, Lee HH, Kim TH.

Anticancer Res. 2019 Sep;39(9):4795-4803. doi: 10.21873/anticanres.13664.


Effects of 1alpha, 25-dihydroxyvitamin D3 on programmed cell death of Ishikawa endometrial cancer cells through ezrin phosphorylation.

Kim TH, Park J, Lee JS, Lee HH.

J Obstet Gynaecol. 2017 May;37(4):503-509. doi: 10.1080/01443615.2016.1271777. Epub 2017 Feb 25.


Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer.

Baker AF, Koh MY, Williams RR, James B, Wang H, Tate WR, Gallegos A, Von Hoff DD, Han H, Powis G.

Pancreas. 2008 Mar;36(2):178-86. doi: 10.1097/MPA.0b013e31815929fe.


Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer.

Li W, Wu Z, Ma Q, Liu J, Xu Q, Han L, Duan W, Lv Y, Wang F, Reindl KM, Wu E.

Curr Cancer Drug Targets. 2014;14(4):348-56.


Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells.

Shah A, Xia L, Goldberg H, Lee KW, Quaggin SE, Fantus IG.

J Biol Chem. 2013 Mar 8;288(10):6835-48. doi: 10.1074/jbc.M112.419101. Epub 2013 Jan 17.


Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein.

Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT.

J Biol Chem. 2004 Jul 16;279(29):30369-74. Epub 2004 May 5.


Impaired cardiac anti-oxidant activity in diabetes: human and correlative experimental studies.

Connelly KA, Advani A, Advani SL, Zhang Y, Kim YM, Shen V, Thai K, Kelly DJ, Gilbert RE.

Acta Diabetol. 2014 Oct;51(5):771-82. doi: 10.1007/s00592-014-0608-9. Epub 2014 Jun 13.


Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells.

Li X, Rong Y, Zhang M, Wang XL, LeMaire SA, Coselli JS, Zhang Y, Shen YH.

Biochem Biophys Res Commun. 2009 Apr 17;381(4):660-5. doi: 10.1016/j.bbrc.2009.02.132. Epub 2009 Feb 28.


Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells.

Ho B, Huang G, Golubovskaya VM.

Anticancer Agents Med Chem. 2014 Jan;14(1):3-8.


α-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells.

Lee JS, Ahn JH, Cho YJ, Kim HY, Yang YI, Lee KT, Jang DS, Choi JH.

J Ethnopharmacol. 2015 Jul 1;169:426-34. doi: 10.1016/j.jep.2015.04.029. Epub 2015 May 1.


The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein.

Hwang J, Suh HW, Jeon YH, Hwang E, Nguyen LT, Yeom J, Lee SG, Lee C, Kim KJ, Kang BS, Jeong JO, Oh TK, Choi I, Lee JO, Kim MH.

Nat Commun. 2014;5:2958. doi: 10.1038/ncomms3958.


Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.

Lee LR, Teng PN, Nguyen H, Hood BL, Kavandi L, Wang G, Turbov JM, Thaete LG, Hamilton CA, Maxwell GL, Rodriguez GC, Conrads TP, Syed V.

Cancer Prev Res (Phila). 2013 Jul;6(7):731-43. doi: 10.1158/1940-6207.CAPR-12-0493. Epub 2013 May 16.


Effects of vitamin D3 stimulation of thioredoxin-interacting protein in hepatocellular carcinoma.

Hamilton JP, Potter JJ, Koganti L, Meltzer SJ, Mezey E.

Hepatol Res. 2014 Dec;44(13):1357-66. doi: 10.1111/hepr.12302. Epub 2014 Mar 25.


TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation.

Li J, Yue Z, Xiong W, Sun P, You K, Wang J.

Oncol Rep. 2017 Jun;37(6):3369-3376. doi: 10.3892/or.2017.5577. Epub 2017 Apr 18.


HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity.

Otaki Y, Takahashi H, Watanabe T, Funayama A, Netsu S, Honda Y, Narumi T, Kadowaki S, Hasegawa H, Honda S, Arimoto T, Shishido T, Miyamoto T, Kamata H, Nakajima O, Kubota I.

J Am Heart Assoc. 2016 Jan 21;5(1). pii: e002485. doi: 10.1161/JAHA.115.002485.


Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS/TXNIP/NLRP3 Inflammasome Pathway.

Lu L, Lu Q, Chen W, Li J, Li C, Zheng Z.

J Diabetes Res. 2018 Feb 22;2018:8193523. doi: 10.1155/2018/8193523. eCollection 2018.


All-trans retinoic acid ameliorates hepatic stellate cell activation via suppression of thioredoxin interacting protein expression.

Shimizu H, Tsubota T, Kanki K, Shiota G.

J Cell Physiol. 2018 Jan;233(1):607-616. doi: 10.1002/jcp.25921. Epub 2017 May 19.


Thioredoxin-1 is a novel and attractive therapeutic approach for various diseases including cardiovascular disorders.

Billiet L, Rouis M.

Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):293-6. Review.


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