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Items: 1 to 20 of 97


Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway.

Ying L, Li N, He Z, Zeng X, Nan Y, Chen J, Miao P, Ying Y, Lin W, Zhao X, Lu L, Chen M, Cen W, Guo T, Li X, Huang Z, Wang Y.

Cell Death Dis. 2019 Sep 11;10(9):665. doi: 10.1038/s41419-019-1893-6.


Fibroblast growth factor 21 protects against high glucose induced cellular damage and dysfunction of endothelial nitric-oxide synthase in endothelial cells.

Wang XM, Song SS, Xiao H, Gao P, Li XJ, Si LY.

Cell Physiol Biochem. 2014;34(3):658-71. doi: 10.1159/000363031. Epub 2014 Aug 13.


Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice.

So WY, Cheng Q, Xu A, Lam KS, Leung PS.

Cell Death Dis. 2015 Mar 26;6:e1707. doi: 10.1038/cddis.2015.80.


Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart.

Yang H, Feng A, Lin S, Yu L, Lin X, Yan X, Lu X, Zhang C.

Cell Death Dis. 2018 Feb 14;9(2):227. doi: 10.1038/s41419-018-0307-5.


Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice.

Kim HW, Lee JE, Cha JJ, Hyun YY, Kim JE, Lee MH, Song HK, Nam DH, Han JY, Han SY, Han KH, Kang YS, Cha DR.

Endocrinology. 2013 Sep;154(9):3366-76. doi: 10.1210/en.2012-2276. Epub 2013 Jul 3.


Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice.

Yan X, Chen J, Zhang C, Zeng J, Zhou S, Zhang Z, Lu X, Chen J, Feng W, Li X, Tan Y.

Cardiovasc Diabetol. 2015 Jun 11;14(1):77. doi: 10.1186/s12933-015-0241-0.


Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21.

Iglesias P, Selgas R, Romero S, Díez JJ.

Eur J Endocrinol. 2012 Sep;167(3):301-9. doi: 10.1530/EJE-12-0357. Epub 2012 Jun 27. Review.


Fibroblast growth factor 21 regulates glucose metabolism in part by reducing renal glucose reabsorption.

Li S, Wang N, Guo X, Li J, Zhang T, Ren G, Li D.

Biomed Pharmacother. 2018 Dec;108:355-366. doi: 10.1016/j.biopha.2018.09.078. Epub 2018 Sep 15.


High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signaling.

So WY, Cheng Q, Chen L, Evans-Molina C, Xu A, Lam KS, Leung PS.

Diabetes. 2013 Nov;62(11):3751-9. doi: 10.2337/db13-0645. Epub 2013 Jul 29.


FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice.

Wu F, Wang B, Zhang S, Shi L, Wang Y, Xiong R, Pan X, Gong F, Li X, Lin Z.

Clin Sci (Lond). 2017 Jul 7;131(15):1877-1893. doi: 10.1042/CS20170271. Print 2017 Aug 1.


Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.

Lu J, Xiang G, Liu M, Mei W, Xiang L, Dong J.

Atherosclerosis. 2015 Dec;243(2):438-48. doi: 10.1016/j.atherosclerosis.2015.10.020. Epub 2015 Oct 19.


Dietary polyphenol morin rescues endothelial dysfunction in a diabetic mouse model by activating the Akt/eNOS pathway.

Taguchi K, Hida M, Hasegawa M, Matsumoto T, Kobayashi T.

Mol Nutr Food Res. 2016 Mar;60(3):580-8. doi: 10.1002/mnfr.201500618. Epub 2015 Dec 29.


Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice.

Zhang J, Cheng Y, Gu J, Wang S, Zhou S, Wang Y, Tan Y, Feng W, Fu Y, Mellen N, Cheng R, Ma J, Zhang C, Li Z, Cai L.

Clin Sci (Lond). 2016 Apr;130(8):625-41. doi: 10.1042/CS20150623. Epub 2016 Jan 21.


[The Role of GRK2 and Its Potential as a New Therapeutic Target in Diabetic Vascular Complications].

Taguchi K.

Yakugaku Zasshi. 2015;135(8):961-7. doi: 10.1248/yakushi.15-00119. Review. Japanese.


The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling.

Jiang X, Chen J, Zhang C, Zhang Z, Tan Y, Feng W, Skibba M, Xin Y, Cai L.

Endocrinology. 2015 Mar;156(3):1156-70. doi: 10.1210/en.2014-1619. Epub 2015 Jan 5.


Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model.

Shao M, Yu L, Zhang F, Lu X, Li X, Cheng P, Lin X, He L, Jin S, Tan Y, Yang H, Zhang C, Cai L.

Am J Physiol Endocrinol Metab. 2015 Jul 1;309(1):E45-54. doi: 10.1152/ajpendo.00026.2015. Epub 2015 May 12.


TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction.

Sun J, Pu Y, Wang P, Chen S, Zhao Y, Liu C, Shang Q, Zhu Z, Liu D.

Cardiovasc Diabetol. 2013 Apr 22;12:69. doi: 10.1186/1475-2840-12-69.


GPER inhibits diabetes-mediated RhoA activation to prevent vascular endothelial dysfunction.

Li Z, Cheng L, Liang H, Duan W, Hu J, Zhi W, Yang J, Liu Z, Zhao M, Liu J.

Eur J Cell Biol. 2016 Feb;95(2):100-13. doi: 10.1016/j.ejcb.2015.12.002. Epub 2015 Dec 29.


FGF21 attenuates hypoxia‑induced dysfunction and apoptosis in HPAECs through alleviating endoplasmic reticulum stress.

Chen A, Liu J, Zhu J, Wang X, Xu Z, Cui Z, Yao D, Huang Z, Xu M, Chen M, Wu P, Li M, Wang L, Huang X.

Int J Mol Med. 2018 Sep;42(3):1684-1694. doi: 10.3892/ijmm.2018.3705. Epub 2018 May 24.


Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.

Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, Patel J, Ge H, Weiszmann J, Lu SC, Graham M, Busby J, Hecht R, Li YS, Li Y, Lindberg R, Véniant MM.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1105-14. doi: 10.1152/ajpendo.00348.2009. Epub 2009 Aug 25.

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