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Items: 1 to 20 of 100

1.

High-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice.

Xi XX, Sun J, Chen HC, Chen AD, Gao LP, Yin J, Jing YH.

Front Aging Neurosci. 2019 Aug 27;11:225. doi: 10.3389/fnagi.2019.00225. eCollection 2019.

2.

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

Diabetes. 2000 Dec;49(12):2056-62.

PMID:
11118007
3.

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

Diabetes. 2003 Feb;52(2):372-9.

4.

Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in hIAPP transgenic mice.

Templin AT, Meier DT, Willard JR, Wolden-Hanson T, Conway K, Lin YG, Gillespie PJ, Bokvist KB, Attardo G, Kahn SE, Scheuner D, Hull RL.

Diabetologia. 2018 Oct;61(10):2215-2224. doi: 10.1007/s00125-018-4695-y. Epub 2018 Jul 25.

5.

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.

Kim J, Cheon H, Jeong YT, Quan W, Kim KH, Cho JM, Lim YM, Oh SH, Jin SM, Kim JH, Lee MK, Kim S, Komatsu M, Kang SW, Lee MS.

J Clin Invest. 2014 Aug;124(8):3311-24. doi: 10.1172/JCI69625. Epub 2014 Jul 18.

6.

Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice.

Aitken JF, Loomes KM, Scott DW, Reddy S, Phillips AR, Prijic G, Fernando C, Zhang S, Broadhurst R, L'Huillier P, Cooper GJ.

Diabetes. 2010 Jan;59(1):161-71. doi: 10.2337/db09-0548. Epub 2009 Sep 30.

7.

Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.

Höppener JW, Jacobs HM, Wierup N, Sotthewes G, Sprong M, de Vos P, Berger R, Sundler F, Ahrén B.

Exp Diabetes Res. 2008;2008:697035. doi: 10.1155/2008/697035.

8.

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice.

Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):625-631. doi: 10.1016/j.bbrc.2016.11.083. Epub 2016 Nov 16.

PMID:
27865831
9.

Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.

Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.

J Clin Invest. 2014 Aug;124(8):3634-44. doi: 10.1172/JCI69866. Epub 2014 Jul 18.

10.

Biologically active human islet amyloid polypeptide/amylin in transgenic mice.

van Hulst KL, Born W, Muff R, Oosterwijk C, Blankenstein MA, Lips CJ, Fischer JA, Höppener JW.

Eur J Endocrinol. 1997 Jan;136(1):107-13.

PMID:
9037136
11.

Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis.

Zraika S, Hull RL, Udayasankar J, Clark A, Utzschneider KM, Tong J, Gerchman F, Kahn SE.

Diabetes. 2007 Feb;56(2):304-10. Erratum in: Diabetes. 2007 Jun;56(6):1746.

12.

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets.

Meier DT, Entrup L, Templin AT, Hogan MF, Mellati M, Zraika S, Hull RL, Kahn SE.

Diabetologia. 2016 Oct;59(10):2166-71. doi: 10.1007/s00125-016-4045-x. Epub 2016 Sep 1.

13.

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1656-62. Epub 2007 Oct 2.

14.

ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.

Wijesekara N, Kaur A, Westwell-Roper C, Nackiewicz D, Soukhatcheva G, Hayden MR, Verchere CB.

Diabetologia. 2016 Jun;59(6):1242-6. doi: 10.1007/s00125-016-3907-6. Epub 2016 Mar 12.

PMID:
26970755
15.

Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice.

Wong HY, Ahrén B, Lips CJ, Höppener JW, Sundler F.

Regul Pept. 2003 May 15;113(1-3):89-94.

PMID:
12686466
16.

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.

17.

Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis.

Kong S, Ruan J, Zhang K, Hu B, Cheng Y, Zhang Y, Yang S, Li K.

PeerJ. 2018 Apr 17;6:e4542. doi: 10.7717/peerj.4542. eCollection 2018.

18.

Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

D'Alessio DA, Verchere CB, Kahn SE, Hoagland V, Baskin DG, Palmiter RD, Ensinck JW.

Diabetes. 1994 Dec;43(12):1457-61.

PMID:
7958499
19.

Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice.

Meier DT, Morcos M, Samarasekera T, Zraika S, Hull RL, Kahn SE.

Diabetologia. 2014 Sep;57(9):1884-8. doi: 10.1007/s00125-014-3304-y. Epub 2014 Jun 26.

20.

Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo.

Mo XD, Gao LP, Wang QJ, Yin J, Jing YH.

Lipids Health Dis. 2018 Mar 9;17(1):42. doi: 10.1186/s12944-018-0694-8.

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