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Applied electric fields suppress osimertinib-induced cytotoxicity via inhibiting FOXO3a nuclear translocation through AKT activation.

Li L, Hu C, Lu C, Zhang K, Han R, Lin C, Zhao S, A C, Cheng C, Zhao M, He Y.

Carcinogenesis. 2019 Aug 31. pii: bgz150. doi: 10.1093/carcin/bgz150. [Epub ahead of print]


Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300.

Jeung YJ, Kim HG, Ahn J, Lee HJ, Lee SB, Won M, Jung CR, Im JY, Kim BK, Park SK, Son MJ, Chung KS.

Biochim Biophys Acta. 2016 Nov;1863(11):2584-2593. doi: 10.1016/j.bbamcr.2016.07.005. Epub 2016 Jul 21.


Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells.

Zeng B, Li Y, Niu B, Wang X, Cheng Y, Zhou Z, You T, Liu Y, Wang H, Xu J.

J Mol Neurosci. 2016 Aug;59(4):567-78. doi: 10.1007/s12031-016-0779-7. Epub 2016 Jul 13.


Fluid shear stress suppresses TNF-α-induced apoptosis in MC3T3-E1 cells: Involvement of ERK5-AKT-FoxO3a-Bim/FasL signaling pathways.

Bin G, Bo Z, Jing W, Jin J, Xiaoyi T, Cong C, Liping A, Jinglin M, Cuifang W, Yonggang C, Yayi X.

Exp Cell Res. 2016 May 1;343(2):208-217. doi: 10.1016/j.yexcr.2016.03.014. Epub 2016 Apr 6.


Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.

Yan F, Liao R, Farhan M, Wang T, Chen J, Wang Z, Little PJ, Zheng W.

Biomed Pharmacother. 2016 Dec;84:1538-1550. doi: 10.1016/j.biopha.2016.11.027. Epub 2016 Nov 20.


Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC.

La Monica S, Minari R, Cretella D, Flammini L, Fumarola C, Bonelli M, Cavazzoni A, Digiacomo G, Galetti M, Madeddu D, Falco A, Lagrasta CA, Squadrilli A, Barocelli E, Romanel A, Quaini F, Petronini PG, Tiseo M, Alfieri R.

J Exp Clin Cancer Res. 2019 May 28;38(1):222. doi: 10.1186/s13046-019-1240-x.


Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway.

Hou Y, Sun G, Jiang X, Zhu Z, Yang J.

J Cancer Res Ther. 2018 Dec;14(Supplement):S1124-S1128. doi: 10.4103/0973-1482.204891.


Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.

Zhang L, Yang X, Li X, Li C, Zhao L, Zhou Y, Hou H.

Int J Mol Med. 2015 Oct;36(4):957-66. doi: 10.3892/ijmm.2015.2324. Epub 2015 Aug 24.


The PI3K/Akt/FOXO3a/p27Kip1 signaling contributes to anti-inflammatory drug-suppressed proliferation of human osteoblasts.

Li CJ, Chang JK, Chou CH, Wang GJ, Ho ML.

Biochem Pharmacol. 2010 Mar 15;79(6):926-37. doi: 10.1016/j.bcp.2009.10.019. Epub 2009 Oct 31.


Apelin induces vascular smooth muscle cells migration via a PI3K/Akt/FoxO3a/MMP-2 pathway.

Wang C, Wen J, Zhou Y, Li L, Cui X, Wang J, Pan L, Ye Z, Liu P, Wu L.

Int J Biochem Cell Biol. 2015 Dec;69:173-82. doi: 10.1016/j.biocel.2015.10.015. Epub 2015 Oct 19.


Piperlongumine-induced nuclear translocation of the FOXO3A transcription factor triggers BIM-mediated apoptosis in cancer cells.

Liu Z, Shi Z, Lin J, Zhao S, Hao M, Xu J, Li Y, Zhao Q, Tao L, Diao A.

Biochem Pharmacol. 2019 May;163:101-110. doi: 10.1016/j.bcp.2019.02.012. Epub 2019 Feb 10.


Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism-Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer.

Tanimoto A, Takeuchi S, Arai S, Fukuda K, Yamada T, Roca X, Ong ST, Yano S.

Clin Cancer Res. 2017 Jun 15;23(12):3139-3149. doi: 10.1158/1078-0432.CCR-16-2271. Epub 2016 Dec 16.


Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells.

Chen Q, Ganapathy S, Singh KP, Shankar S, Srivastava RK.

PLoS One. 2010 Dec 14;5(12):e15288. doi: 10.1371/journal.pone.0015288.


Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium.

Fujiki K, Inamura H, Matsuoka M.

Arch Toxicol. 2013 Dec;87(12):2119-27. doi: 10.1007/s00204-013-1077-6. Epub 2013 May 15.


Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer.

Li L, Wang Y, Jiao L, Lin C, Lu C, Zhang K, Hu C, Ye J, Zhang D, Wu H, Feng M, He Y.

Cancer Lett. 2019 Jun 28;452:191-202. doi: 10.1016/j.canlet.2019.03.027. Epub 2019 Mar 22.


Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer.

Chen J, Gomes AR, Monteiro LJ, Wong SY, Wu LH, Ng TT, Karadedou CT, Millour J, Ip YC, Cheung YN, Sunters A, Chan KY, Lam EW, Khoo US.

PLoS One. 2010 Aug 20;5(8):e12293. doi: 10.1371/journal.pone.0012293.


The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cells.

Wang H, Zhou X, Huang J, Mu N, Guo Z, Wen Q, Wang R, Chen S, Feng ZP, Zheng W.

Psychopharmacology (Berl). 2013 Jul;228(1):129-41. doi: 10.1007/s00213-013-3017-9. Epub 2013 Mar 15.


FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells.

Shukla S, Rizvi F, Raisuddin S, Kakkar P.

Free Radic Biol Med. 2014 Nov;76:185-99. doi: 10.1016/j.freeradbiomed.2014.07.039. Epub 2014 Aug 13.


Regulation of the FOXO3a/Bim signaling pathway by 5,7-dihydroxy-8-nitrochrysin in MDA-MB-453 breast cancer cells.

Zhao XC, Cao XC, Liu F, Quan MF, Ren KQ, Cao JG.

Oncol Lett. 2013 Mar;5(3):929-934. Epub 2012 Dec 14.

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