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N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats.

Han B, Chu C, Su X, Zhang N, Zhou L, Zhang M, Yang S, Shi L, Zhao B, Niu Y, Zhang R.

Nanotoxicology. 2019 Sep 10:1-20. doi: 10.1080/17435390.2019.1661041. [Epub ahead of print]


N6-methyladenosine marks primary microRNAs for processing.

Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF.

Nature. 2015 Mar 26;519(7544):482-5. doi: 10.1038/nature14281. Epub 2015 Mar 18.


CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity.

Hines JP, Smith AT, Jacob JP, Lukat-Rodgers GS, Barr I, Rodgers KR, Guo F, Burstyn JN.

J Biol Inorg Chem. 2016 Dec;21(8):1021-1035. Epub 2016 Oct 20.


SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.

Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y, Yu J.

Nucleic Acids Res. 2015 Sep 18;43(16):7945-60. doi: 10.1093/nar/gkv741. Epub 2015 Jul 21.


The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.

Roth BM, Ishimaru D, Hennig M.

J Biol Chem. 2013 Sep 13;288(37):26785-99. doi: 10.1074/jbc.M112.446880. Epub 2013 Jul 26.


Processing of microRNA primary transcripts requires heme in mammalian cells.

Weitz SH, Gong M, Barr I, Weiss S, Guo F.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1861-6. doi: 10.1073/pnas.1309915111. Epub 2014 Jan 21.


DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures.

Faller M, Toso D, Matsunaga M, Atanasov I, Senturia R, Chen Y, Zhou ZH, Guo F.

RNA. 2010 Aug;16(8):1570-83. doi: 10.1261/rna.2111310. Epub 2010 Jun 17.


Functional Dissection of pri-miR-290~295 in Dgcr8 Knockout Mouse Embryonic Stem Cells.

Shi M, Hao J, Wang XW, Liao LQ, Cao H, Wang Y.

Int J Mol Sci. 2019 Sep 5;20(18). pii: E4345. doi: 10.3390/ijms20184345.


The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.

Tu CC, Zhong Y, Nguyen L, Tsai A, Sridevi P, Tarn WY, Wang JY.

Sci Signal. 2015 Jun 30;8(383):ra64. doi: 10.1126/scisignal.aaa4468.


Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways.

Gomez O, Sanchez-Rodriguez A, Le M, Sanchez-Caro C, Molina-Holgado F, Molina-Holgado E.

Br J Pharmacol. 2011 Aug;163(7):1520-32. doi: 10.1111/j.1476-5381.2011.01414.x.


Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing.

Yeom KH, Lee Y, Han J, Suh MR, Kim VN.

Nucleic Acids Res. 2006;34(16):4622-9. Epub 2006 Sep 8.


Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in rat lung DNA following subchronic inhalation of carbon black.

Gallagher J, Sams R 2nd, Inmon J, Gelein R, Elder A, Oberdörster G, Prahalad AK.

Toxicol Appl Pharmacol. 2003 Aug 1;190(3):224-31.


Thy-1 depletion and integrin β3 upregulation-mediated PI3K-Akt-mTOR pathway activation inhibits lung fibroblast autophagy in lipopolysaccharide-induced pulmonary fibrosis.

Wan H, Xie T, Xu Q, Hu X, Xing S, Yang H, Gao Y, He Z.

Lab Invest. 2019 Jun 27. doi: 10.1038/s41374-019-0281-2. [Epub ahead of print]


Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects.

Chu C, Zhou L, Xie H, Pei Z, Zhang M, Wu M, Zhang S, Wang L, Zhao C, Shi L, Zhang N, Niu Y, Zheng Y, Zhang R.

Int J Nanomedicine. 2019 Apr 30;14:2995-3013. doi: 10.2147/IJN.S198376. eCollection 2019.


MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1.

Yan W, Wu Q, Yao W, Li Y, Liu Y, Yuan J, Han R, Yang J, Ji X, Ni C.

Sci Rep. 2017 Sep 12;7(1):11313. doi: 10.1038/s41598-017-11904-8.


[Comparison study on the differential expression of miRNAs in rat pulmonary fibrosis induced by nanosized SiO(2) and microsized SiO(2)].

Yang H, Li MY, Li WC, Zhang YJ, Lao CS.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2019 Feb 20;37(2):81-89. doi: 10.3760/cma.j.issn.1001-9391.2019.02.001. Chinese.


Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.

Barr I, Smith AT, Chen Y, Senturia R, Burstyn JN, Guo F.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1919-24. doi: 10.1073/pnas.1114514109. Epub 2012 Jan 23.


Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers.

Zhang R, Dai Y, Zhang X, Niu Y, Meng T, Li Y, Duan H, Bin P, Ye M, Jia X, Shen M, Yu S, Yang X, Gao W, Zheng Y.

Part Fibre Toxicol. 2014 Dec 14;11:73. doi: 10.1186/s12989-014-0073-1.

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