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Items: 1 to 20 of 103


Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.

Zhang C, Xie H, Yang Q, Yang Y, Li W, Tian H, Lu L, Wang F, Xu JY, Gao F, Wang J, Jin C, Xu G, Xu GT, Zhang J.

Clin Exp Ophthalmol. 2019 Sep 4. doi: 10.1111/ceo.13619. [Epub ahead of print]


Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.

Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3425-34. doi: 10.1073/pnas.1217091110. Epub 2013 Aug 19.


Angiopoietin-like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells.

Yokouchi H, Eto K, Nishimura W, Takeda N, Kaburagi Y, Yamamoto S, Yasuda K.

Acta Ophthalmol. 2013 Jun;91(4):e289-97. doi: 10.1111/aos.12097. Epub 2013 Feb 7.


Decorin Prevents Retinal Pigment Epithelial Barrier Breakdown Under Diabetic Conditions by Suppressing p38 MAPK Activation.

Wang S, Du S, Wu Q, Hu J, Li T.

Invest Ophthalmol Vis Sci. 2015 May;56(5):2971-9. doi: 10.1167/iovs.14-15874.


L-mimosine and hypoxia enhance angiopoietin-like 4 production involving hypoxia-inducible factor-1alpha: Insights from monolayer and spheroid cultures of dental pulp-derived cells and tooth slice cultures.

Janjić K, Alhujazy U, Moritz A, Agis H.

Arch Oral Biol. 2018 Jan;85:172-177. doi: 10.1016/j.archoralbio.2017.10.011. Epub 2017 Oct 16.


Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer.

Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H.

Oncol Lett. 2016 Feb;11(2):1026-1034. Epub 2015 Dec 8.


Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.

Wu J, Ke X, Fu W, Gao X, Zhang H, Wang W, Ma N, Zhao M, Hao X, Zhang Z.

Molecules. 2016 Dec 21;21(12). pii: E1756. doi: 10.3390/molecules21121756.


Up-Regulation of ENO1 by HIF-1α in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion.

Zheng F, Jang WC, Fung FK, Lo AC, Wong IY.

PLoS One. 2016 Feb 16;11(2):e0147961. doi: 10.1371/journal.pone.0147961. eCollection 2016.


Formononetin, an active compound of Astragalus membranaceus (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathway.

Wu J, Ke X, Ma N, Wang W, Fu W, Zhang H, Zhao M, Gao X, Hao X, Zhang Z.

Drug Des Devel Ther. 2016 Sep 23;10:3071-3081. eCollection 2016.


Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema.

Sodhi A, Ma T, Menon D, Deshpande M, Jee K, Dinabandhu A, Vancel J, Lu D, Montaner S.

J Clin Invest. 2019 Sep 23. pii: 120879. doi: 10.1172/JCI120879. [Epub ahead of print]


Tongxinluo attenuates reperfusion injury in diabetic hearts by angiopoietin-like 4-mediated protection of endothelial barrier integrity via PPAR-α pathway.

Qi K, Li X, Geng Y, Cui H, Jin C, Wang P, Li Y, Yang Y.

PLoS One. 2018 Jun 18;13(6):e0198403. doi: 10.1371/journal.pone.0198403. eCollection 2018.


Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.

Poulaki V, Qin W, Joussen AM, Hurlbut P, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP.

J Clin Invest. 2002 Mar;109(6):805-15.


Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis.

Zhang T, Kastrenopoulou A, Larrouture Q, Athanasou NA, Knowles HJ.

BMC Cancer. 2018 May 8;18(1):536. doi: 10.1186/s12885-018-4468-5.


High glucose concentration leads to differential expression of tight junction proteins in human retinal pigment epithelial cells.

Villarroel M, García-Ramírez M, Corraliza L, Hernández C, Simó R.

Endocrinol Nutr. 2009 Feb;56(2):53-8. doi: 10.1016/S1575-0922(09)70552-2. Epub 2009 May 1.


Placental growth factor-1 and epithelial haemato-retinal barrier breakdown: potential implication in the pathogenesis of diabetic retinopathy.

Miyamoto N, de Kozak Y, Jeanny JC, Glotin A, Mascarelli F, Massin P, BenEzra D, Behar-Cohen F.

Diabetologia. 2007 Feb;50(2):461-70. Epub 2006 Dec 23.


Enhanced ROBO4 is mediated by up-regulation of HIF-1α/SP1 or reduction in miR-125b-5p/miR-146a-5p in diabetic retinopathy.

Gong Q, Xie J, Li Y, Liu Y, Su G.

J Cell Mol Med. 2019 Jul;23(7):4723-4737. doi: 10.1111/jcmm.14369. Epub 2019 May 15.


ANGPTL-4 induces diabetic retinal inflammation by activating Profilin-1.

Lu Q, Lu P, Chen W, Lu L, Zheng Z.

Exp Eye Res. 2018 Jan;166:140-150. doi: 10.1016/j.exer.2017.10.009. Epub 2017 Oct 13.


The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown.

Abu El-Asrar AM, Mohammad G, Nawaz MI, Abdelsaid M, Siddiquei MM, Alam K, Van den Eynde K, De Hertogh G, Opdenakker G, Al-Shabrawey M, Van Damme J, Struyf S.

Invest Ophthalmol Vis Sci. 2015 Feb 24;56(3):1956-64. doi: 10.1167/iovs.14-16144.

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