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An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.

Jin M, Han W, Liu C, Zang Y, Li J, Wang F, Wang Y, Cong Y.

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19513-19522. doi: 10.1073/pnas.1903976116. Epub 2019 Sep 6.


Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.

Zang Y, Jin M, Wang H, Cui Z, Kong L, Liu C, Cong Y.

Nat Struct Mol Biol. 2016 Dec;23(12):1083-1091. doi: 10.1038/nsmb.3309. Epub 2016 Oct 24.


Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle.

Cong Y, Schröder GF, Meyer AS, Jakana J, Ma B, Dougherty MT, Schmid MF, Reissmann S, Levitt M, Ludtke SL, Frydman J, Chiu W.

EMBO J. 2012 Feb 1;31(3):720-30. doi: 10.1038/emboj.2011.366. Epub 2011 Nov 1.


4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement.

Cong Y, Baker ML, Jakana J, Woolford D, Miller EJ, Reissmann S, Kumar RN, Redding-Johanson AM, Batth TS, Mukhopadhyay A, Ludtke SJ, Frydman J, Chiu W.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4967-72. doi: 10.1073/pnas.0913774107. Epub 2010 Mar 1.


The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.

Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J.

Cell. 2019 Apr 18;177(3):751-765.e15. doi: 10.1016/j.cell.2019.03.012. Epub 2019 Apr 4.


Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT.

Booth CR, Meyer AS, Cong Y, Topf M, Sali A, Ludtke SJ, Chiu W, Frydman J.

Nat Struct Mol Biol. 2008 Jul;15(7):746-53. doi: 10.1038/nsmb.1436. Epub 2008 Jun 8.


Mechanism of folding chamber closure in a group II chaperonin.

Zhang J, Baker ML, Schröder GF, Douglas NR, Reissmann S, Jakana J, Dougherty M, Fu CJ, Levitt M, Ludtke SJ, Frydman J, Chiu W.

Nature. 2010 Jan 21;463(7279):379-83. doi: 10.1038/nature08701.


Co-expression of CCT subunits hints at TRiC assembly.

Sergeeva OA, Haase-Pettingell C, King JA.

Cell Stress Chaperones. 2019 Aug 13. doi: 10.1007/s12192-019-01028-5. [Epub ahead of print]


The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story.

Gestaut D, Limatola A, Joachimiak L, Frydman J.

Curr Opin Struct Biol. 2019 Apr;55:50-58. doi: 10.1016/ Epub 2019 Apr 9. Review.


Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT.

Zang Y, Wang H, Cui Z, Jin M, Liu C, Han W, Wang Y, Cong Y.

Sci Rep. 2018 Feb 5;8(1):2374. doi: 10.1038/s41598-017-18962-y.


Transient Kinetic Analysis of ATP Hydrolysis by the CCT/TRiC Chaperonin.

Korobko I, Nadler-Holly M, Horovitz A.

J Mol Biol. 2016 Nov 6;428(22):4520-4527. doi: 10.1016/j.jmb.2016.09.017. Epub 2016 Sep 26.


Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC.

Balchin D, Miličić G, Strauss M, Hayer-Hartl M, Hartl FU.

Cell. 2018 Sep 6;174(6):1507-1521.e16. doi: 10.1016/j.cell.2018.07.006. Epub 2018 Aug 9.


Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.

Sergeeva OA, Chen B, Haase-Pettingell C, Ludtke SJ, Chiu W, King JA.

J Biol Chem. 2013 Jun 14;288(24):17734-44. doi: 10.1074/jbc.M112.443929. Epub 2013 Apr 23.


Crystal structure of a GroEL-ADP complex in the relaxed allosteric state at 2.7 Å resolution.

Fei X, Yang D, LaRonde-LeBlanc N, Lorimer GH.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2958-66. doi: 10.1073/pnas.1311996110. Epub 2013 Jul 16.


Yeast Inner-Subunit PA-NZ-1 Labeling Strategy for Accurate Subunit Identification in a Macromolecular Complex through Cryo-EM Analysis.

Wang H, Han W, Takagi J, Cong Y.

J Mol Biol. 2018 May 11;430(10):1417-1425. doi: 10.1016/j.jmb.2018.03.026. Epub 2018 Apr 4.


The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.

Zebol JR, Hewitt NM, Moretti PA, Lynn HE, Lake JA, Li P, Vadas MA, Wattenberg BW, Pitson SM.

Int J Biochem Cell Biol. 2009 Apr;41(4):822-7. doi: 10.1016/j.biocel.2008.08.012. Epub 2008 Aug 14.


Determining the Crystal Structure of TRPV6.

Saotome K, Singh AK, Sobolevsky AI.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 14.


Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT.

Rüßmann F, Stemp MJ, Mönkemeyer L, Etchells SA, Bracher A, Hartl FU.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21208-15. doi: 10.1073/pnas.1218836109. Epub 2012 Nov 28.


In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly.

Berger J, Berger S, Li M, Jacoby AS, Arner A, Bavi N, Stewart AG, Currie PD.

Cell Rep. 2018 Jan 9;22(2):313-322. doi: 10.1016/j.celrep.2017.12.069.


Sequential ATP-induced allosteric transitions of the cytoplasmic chaperonin containing TCP-1 revealed by EM analysis.

Rivenzon-Segal D, Wolf SG, Shimon L, Willison KR, Horovitz A.

Nat Struct Mol Biol. 2005 Mar;12(3):233-7. Epub 2005 Feb 6.


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