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PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1.

Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L, Zheng Y, Zhao D, Zhang C, Lorenzi PL, You Y, Jiang BH, Jiang T, Li H, Lu Z.

Mol Cell. 2019 Aug 22. pii: S1097-2765(19)30622-7. doi: 10.1016/j.molcel.2019.08.006. [Epub ahead of print]


Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.

Li X, Jiang Y, Meisenhelder J, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, Lu Z.

Mol Cell. 2016 Mar 3;61(5):705-719. doi: 10.1016/j.molcel.2016.02.009.


Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis.

Zhang Y, Yu G, Chu H, Wang X, Xiong L, Cai G, Liu R, Gao H, Tao B, Li W, Li G, Liang J, Yang W.

Mol Cell. 2018 Jul 19;71(2):201-215.e7. doi: 10.1016/j.molcel.2018.06.023.


Protein kinase activity of the glycolytic enzyme PGK1 regulates autophagy to promote tumorigenesis.

Qian X, Li X, Lu Z.

Autophagy. 2017 Jul 3;13(7):1246-1247. doi: 10.1080/15548627.2017.1313945. Epub 2017 May 9.


PTEN inhibits BMI1 function independently of its phosphatase activity.

Fan C, He L, Kapoor A, Rybak AP, De Melo J, Cutz JC, Tang D.

Mol Cancer. 2009 Nov 10;8:98. doi: 10.1186/1476-4598-8-98.


Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1.

Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan KL.

PLoS Biol. 2015 Sep 10;13(9):e1002243. doi: 10.1371/journal.pbio.1002243. eCollection 2015. Erratum in: PLoS Biol. 2015 Nov;13(11):e1002287.


Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis.

Beckner ME, Gobbel GT, Abounader R, Burovic F, Agostino NR, Laterra J, Pollack IF.

Lab Invest. 2005 Dec;85(12):1457-70.


Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S.

Oncogene. 2005 May 19;24(22):3596-605.


Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy.

Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z.

Mol Cell. 2017 Mar 2;65(5):917-931.e6. doi: 10.1016/j.molcel.2017.01.027. Epub 2017 Feb 23.


Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis.

Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, de Groot JF, Jiang T, Lu Z.

Nat Commun. 2017 Oct 16;8(1):949. doi: 10.1038/s41467-017-00906-9.


CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction.

Yeung YT, Fan S, Lu B, Yin S, Yang S, Nie W, Wang M, Zhou L, Li T, Li X, Bode AM, Dong Z.

Carcinogenesis. 2019 Jun 25. pii: bgz113. doi: 10.1093/carcin/bgz113. [Epub ahead of print]


Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis.

Shao F, Yang X, Wang W, Wang J, Guo W, Feng X, Shi S, Xue Q, Gao S, Gao Y, Lu Z, He J.

Cancer Commun (Lond). 2019 Oct 2;39(1):54. doi: 10.1186/s40880-019-0401-9.


Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation.

Molina JR, Morales FC, Hayashi Y, Aldape KD, Georgescu MM.

Cancer Res. 2010 Sep 1;70(17):6697-703. doi: 10.1158/0008-5472.CAN-10-1271. Epub 2010 Aug 24.


Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis.

Hu H, Zhu W, Qin J, Chen M, Gong L, Li L, Liu X, Tao Y, Yin H, Zhou H, Zhou L, Ye D, Ye Q, Gao D.

Hepatology. 2017 Feb;65(2):515-528. doi: 10.1002/hep.28887. Epub 2016 Nov 29.


PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis.

Xu W, Yang Z, Xie C, Zhu Y, Shu X, Zhang Z, Li N, Chai N, Zhang S, Wu K, Nie Y, Lu N.

J Exp Clin Cancer Res. 2018 Aug 22;37(1):198. doi: 10.1186/s13046-018-0795-2.


Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α.

Wan W, Peng K, Li M, Qin L, Tong Z, Yan J, Shen B, Yu C.

Oncogene. 2017 Jul 6;36(27):3868-3877. doi: 10.1038/onc.2017.13. Epub 2017 Mar 6.


Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells.

Cordero-Espinoza L, Hagen T.

J Biol Chem. 2013 Dec 13;288(50):36020-8. doi: 10.1074/jbc.M113.510289. Epub 2013 Oct 29.

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