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Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.

Käshammer L, Saathoff JH, Lammens K, Gut F, Bartho J, Alt A, Kessler B, Hopfner KP.

Mol Cell. 2019 Aug 26. pii: S1097-2765(19)30590-8. doi: 10.1016/j.molcel.2019.07.035. [Epub ahead of print]


ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex.

Möckel C, Lammens K, Schele A, Hopfner KP.

Nucleic Acids Res. 2012 Jan;40(2):914-27. doi: 10.1093/nar/gkr749. Epub 2011 Sep 21.


Coordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex.

Almond JR, Stohr BA, Panigrahi AK, Albrecht DW, Nelson SW, Kreuzer KN.

Genetics. 2013 Nov;195(3):739-55. doi: 10.1534/genetics.113.154872. Epub 2013 Aug 26.


Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.

Hopfner KP, Karcher A, Craig L, Woo TT, Carney JP, Tainer JA.

Cell. 2001 May 18;105(4):473-85.


The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.

Lammens K, Bemeleit DJ, Möckel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermüller C, Söding J, Strässer K, Hopfner KP.

Cell. 2011 Apr 1;145(1):54-66. doi: 10.1016/j.cell.2011.02.038.


Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy.

Anderson DE, Trujillo KM, Sung P, Erickson HP.

J Biol Chem. 2001 Oct 5;276(40):37027-33. Epub 2001 Jul 24.


Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Langerak P, Mejia-Ramirez E, Limbo O, Russell P.

PLoS Genet. 2011 Sep;7(9):e1002271. doi: 10.1371/journal.pgen.1002271. Epub 2011 Sep 8.


Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.

Rojowska A, Lammens K, Seifert FU, Direnberger C, Feldmann H, Hopfner KP.

EMBO J. 2014 Dec 1;33(23):2847-59. doi: 10.15252/embj.201488889. Epub 2014 Oct 27.


The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.

Hopfner KP, Craig L, Moncalian G, Zinkel RA, Usui T, Owen BA, Karcher A, Henderson B, Bodmer JL, McMurray CT, Carney JP, Petrini JH, Tainer JA.

Nature. 2002 Aug 1;418(6897):562-6.


The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.

Hohl M, Kwon Y, Galván SM, Xue X, Tous C, Aguilera A, Sung P, Petrini JH.

Nat Struct Mol Biol. 2011 Sep 4;18(10):1124-31. doi: 10.1038/nsmb.2116.


Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

Williams RS, Williams JS, Tainer JA.

Biochem Cell Biol. 2007 Aug;85(4):509-20. Review.


Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.

Seifert FU, Lammens K, Stoehr G, Kessler B, Hopfner KP.

EMBO J. 2016 Apr 1;35(7):759-72. doi: 10.15252/embj.201592934. Epub 2016 Feb 19.


Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe.

Li Y, Wang J, Zhou G, Lajeunesse M, Le N, Stawicki BN, Corcino YL, Berkner KL, Runge KW.

Genetics. 2017 May;206(1):481-496. doi: 10.1534/genetics.117.200972. Epub 2017 Mar 14.


Structural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repair.

Liu S, Tian LF, Liu YP, An XM, Tang Q, Yan XX, Liang DC.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):299-309. doi: 10.1107/S139900471302693X. Epub 2014 Jan 29.


Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain.

Barfoot T, Herdendorf TJ, Behning BR, Stohr BA, Gao Y, Kreuzer KN, Nelson SW.

J Biol Chem. 2015 Sep 25;290(39):23905-15. doi: 10.1074/jbc.M115.675132. Epub 2015 Aug 4.


Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.

Lafrance-Vanasse J, Williams GJ, Tainer JA.

Prog Biophys Mol Biol. 2015 Mar;117(2-3):182-193. doi: 10.1016/j.pbiomolbio.2014.12.004. Epub 2015 Jan 7. Review.


Autoinhibition of bacteriophage T4 Mre11 by its C-terminal domain.

Gao Y, Nelson SW.

J Biol Chem. 2014 Sep 19;289(38):26505-13. doi: 10.1074/jbc.M114.583625. Epub 2014 Jul 30.


ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

Williams GJ, Williams RS, Williams JS, Moncalian G, Arvai AS, Limbo O, Guenther G, SilDas S, Hammel M, Russell P, Tainer JA.

Nat Struct Mol Biol. 2011 Apr;18(4):423-31. doi: 10.1038/nsmb.2038. Epub 2011 Mar 27. Erratum in: Nat Struct Mol Biol. 2011 Sep;18(9):1084. Nat Struct Mol Biol. 2012 Mar;19(3):364.


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