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Items: 1 to 20 of 98

1.

A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings.

Zhao C, Ye Z, Ma ZX, Wildman SA, Blaszczyk SA, Hu L, Guizei IA, Tang W.

Nat Commun. 2019 Sep 5;10(1):4015. doi: 10.1038/s41467-019-11976-2.

2.

Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012).

Foffi G, Pastore A, Piazza F, Temussi PA.

Phys Biol. 2013 Aug;10(4):040301. Epub 2013 Aug 2.

PMID:
23912807
3.

Chemically engineered extracts: source of bioactive compounds.

Ramallo IA, Salazar MO, Mendez L, Furlan RL.

Acc Chem Res. 2011 Apr 19;44(4):241-50. doi: 10.1021/ar100106n. Epub 2011 Feb 28. Review.

PMID:
21355557
4.

Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.

Bauer RA, Wenderski TA, Tan DS.

Nat Chem Biol. 2013 Jan;9(1):21-9. doi: 10.1038/nchembio.1130. Epub 2012 Nov 18.

5.

Highly Stereoselective Synthesis of a Compound Collection Based on the Bicyclic Scaffolds of Natural Products.

Annamalai M, Hristeva S, Bielska M, Ortega R, Kumar K.

Molecules. 2017 May 18;22(5). pii: E827. doi: 10.3390/molecules22050827.

6.

Applications of Nonenzymatic Catalysts to the Alteration of Natural Products.

Shugrue CR, Miller SJ.

Chem Rev. 2017 Sep 27;117(18):11894-11951. doi: 10.1021/acs.chemrev.7b00022. Epub 2017 Jun 5. Review.

7.

Structural diversity of biologically interesting datasets: a scaffold analysis approach.

Khanna V, Ranganathan S.

J Cheminform. 2011 Aug 8;3:30. doi: 10.1186/1758-2946-3-30.

8.

Biosynthesis of Lincosamide Antibiotics: Reactions Associated with Degradation and Detoxification Pathways Play a Constructive Role.

Zhang D, Tang Z, Liu W.

Acc Chem Res. 2018 Jun 19;51(6):1496-1506. doi: 10.1021/acs.accounts.8b00135. Epub 2018 May 24. Review.

PMID:
29792672
9.

The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery.

Barnes EC, Kumar R, Davis RA.

Nat Prod Rep. 2016 Mar;33(3):372-81. doi: 10.1039/c5np00121h. Epub 2016 Jan 7. Review.

PMID:
26739749
10.

Intramolecular dearomative oxidative coupling of indoles: a unified strategy for the total synthesis of indoline alkaloids.

Zi W, Zuo Z, Ma D.

Acc Chem Res. 2015 Mar 17;48(3):702-11. doi: 10.1021/ar5004303. Epub 2015 Feb 10.

PMID:
25667972
11.

Capturing nature's diversity.

Pascolutti M, Campitelli M, Nguyen B, Pham N, Gorse AD, Quinn RJ.

PLoS One. 2015 Apr 22;10(4):e0120942. doi: 10.1371/journal.pone.0120942. eCollection 2015.

12.

The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids.

Hanessian S, Auzzas L.

Acc Chem Res. 2008 Oct;41(10):1241-51. doi: 10.1021/ar8000052. Epub 2008 Jul 23.

PMID:
18646869
13.

The Evolution of DNA-Templated Synthesis as a Tool for Materials Discovery.

O'Reilly RK, Turberfield AJ, Wilks TR.

Acc Chem Res. 2017 Oct 17;50(10):2496-2509. doi: 10.1021/acs.accounts.7b00280. Epub 2017 Sep 15.

14.

Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics.

Brzozowski RS, Wuest WM.

Chem Biol Drug Des. 2017 Feb;89(2):169-191. doi: 10.1111/cbdd.12783. Review.

PMID:
27153932
15.

Recent Advances in Transition-Metal-Catalyzed/Mediated Transformations of Vinylidenecyclopropanes.

Yang S, Shi M.

Acc Chem Res. 2018 Jul 17;51(7):1667-1680. doi: 10.1021/acs.accounts.8b00171. Epub 2018 Jun 29.

PMID:
29957927
16.

From synthesis to function via iterative assembly of N-methyliminodiacetic acid boronate building blocks.

Li J, Grillo AS, Burke MD.

Acc Chem Res. 2015 Aug 18;48(8):2297-307. doi: 10.1021/acs.accounts.5b00128. Epub 2015 Jul 22.

17.

Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds.

Liao Y, Hu Y, Wu J, Zhu Q, Donovan M, Fathi R, Yang Z.

Curr Med Chem. 2003 Nov;10(21):2285-316. Review.

PMID:
14529343
18.
19.

Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification.

Laraia L, Waldmann H.

Drug Discov Today Technol. 2017 Mar;23:75-82. doi: 10.1016/j.ddtec.2017.03.003. Epub 2017 Apr 14. Review.

PMID:
28647090
20.

Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings.

Li L, Li ZL, Wang FL, Guo Z, Cheng YF, Wang N, Dong XW, Fang C, Liu J, Hou C, Tan B, Liu XY.

Nat Commun. 2016 Dec 22;7:13852. doi: 10.1038/ncomms13852.

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