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Items: 1 to 20 of 102


Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma.

Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, Park DM.

Cancer Res. 2019 Oct 15;79(20):5218-5232. doi: 10.1158/0008-5472.CAN-19-0198. Epub 2019 Sep 5.


Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming.

Ding WX, Ni HM, Li M, Liao Y, Chen X, Stolz DB, Dorn GW 2nd, Yin XM.

J Biol Chem. 2010 Sep 3;285(36):27879-90. doi: 10.1074/jbc.M110.119537. Epub 2010 Jun 23.


Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells.

Takeda M, Koseki J, Takahashi H, Miyoshi N, Nishida N, Nishimura J, Hata T, Matsuda C, Mizushima T, Yamamoto H, Ishii H, Doki Y, Mori M, Haraguchi N.

Cancer Res. 2019 Apr 1;79(7):1426-1437. doi: 10.1158/0008-5472.CAN-18-2192. Epub 2019 Feb 14.


Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.

Natarajan S, Foreman KM, Soriano MI, Rossen NS, Shehade H, Fregoso DR, Eggold JT, Krishnan V, Dorigo O, Krieg AJ, Heilshorn SC, Sinha S, Fuh KC, Rankin EB.

Cancer Res. 2019 May 1;79(9):2271-2284. doi: 10.1158/0008-5472.CAN-18-2616. Epub 2019 Mar 12.


[Research progress on mechanism of Nix-mediated mitophagy].

Zheng Y, Zhang X, Chen Z.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 Jan 25;46(1):92-96. Review. Chinese.


Role of BNIP3 and NIX in cell death, autophagy, and mitophagy.

Zhang J, Ney PA.

Cell Death Differ. 2009 Jul;16(7):939-46. doi: 10.1038/cdd.2009.16. Epub 2009 Feb 20. Review.


Mitophagy mediated by BNIP3 and BNIP3L/NIX in urothelial cells of the urinary bladder of cattle harbouring bovine papillomavirus infection.

Roperto S, De Falco F, Perillo A, Catoi C, Roperto F.

Vet Microbiol. 2019 Sep;236:108396. doi: 10.1016/j.vetmic.2019.108396. Epub 2019 Aug 22.


Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX.

Ney PA.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2775-83. doi: 10.1016/j.bbamcr.2015.02.022. Epub 2015 Mar 6. Review.


Nix-mediated mitophagy regulates platelet activation and life span.

Zhang W, Ma Q, Siraj S, Ney PA, Liu J, Liao X, Yuan Y, Li W, Liu L, Chen Q.

Blood Adv. 2019 Aug 13;3(15):2342-2354. doi: 10.1182/bloodadvances.2019032334.


Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease.

Koentjoro B, Park JS, Sue CM.

Sci Rep. 2017 Mar 10;7:44373. doi: 10.1038/srep44373.


Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.

Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA.

Cancer Discov. 2019 Sep;9(9):1268-1287. doi: 10.1158/2159-8290.CD-18-1409. Epub 2019 Jul 1.


BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke.

Shi RY, Zhu SH, Li V, Gibson SB, Xu XS, Kong JM.

CNS Neurosci Ther. 2014 Dec;20(12):1045-55. doi: 10.1111/cns.12325. Epub 2014 Sep 17.


Nix/BNIP3L-dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke.

Zhang M, Shi R, Zhang Y, Shan H, Zhang Q, Yang X, Li Y, Zhang J.

J Cell Physiol. 2019 Aug;234(8):14210-14220. doi: 10.1002/jcp.28117. Epub 2019 Jan 7.


BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.

Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, Kim T, Sussman MA, Gustafsson ÅB.

Autophagy. 2019 Jul;15(7):1182-1198. doi: 10.1080/15548627.2019.1580095. Epub 2019 Feb 22.


NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury.

Xu D, Chen P, Wang B, Wang Y, Miao N, Yin F, Cheng Q, Zhou Z, Xie H, Zhou L, Liu J, Wang X, Zent R, Lu L, Zhang W.

Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F382-F395. doi: 10.1152/ajprenal.00360.2018. Epub 2018 Sep 12.


Nix protein positively regulates NF-κB activation in gliomas.

Lu Y, Wang L, He M, Huang W, Li H, Wang Y, Kong J, Qi S, Ouyang J, Qiu X.

PLoS One. 2012;7(9):e44559. doi: 10.1371/journal.pone.0044559. Epub 2012 Sep 12.


Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis.

Wang X, Luo G, Zhang K, Cao J, Huang C, Jiang T, Liu B, Su L, Qiu Z.

Cancer Res. 2018 Aug 15;78(16):4586-4598. doi: 10.1158/0008-5472.CAN-17-3841. Epub 2018 Jun 7.


Phylogenetic and Molecular Evolutionary Analysis of Mitophagy Receptors under Hypoxic Conditions.

Wu X, Wu FH, Wu Q, Zhang S, Chen S, Sima M.

Front Physiol. 2017 Jul 26;8:539. doi: 10.3389/fphys.2017.00539. eCollection 2017.


Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus.

Vo MT, Smith BJ, Nicholas J, Choi YB.

Nat Commun. 2019 Jul 19;10(1):3203. doi: 10.1038/s41467-019-11164-2.


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