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TRAF6 promotes the progression and growth of colorectal cancer through nuclear shuttle regulation NF-kB/c-jun signaling pathway.

Zhu G, Cheng Z, Huang Y, Zheng W, Yang S, Lin C, Ye J.

Life Sci. 2019 Sep 2;235:116831. doi: 10.1016/j.lfs.2019.116831. [Epub ahead of print]


TNF receptor-associated factor 6 regulates proliferation, apoptosis, and invasion of glioma cells.

Peng Z, Shuangzhu Y, Yongjie J, Xinjun Z, Ying L.

Mol Cell Biochem. 2013 May;377(1-2):87-96. doi: 10.1007/s11010-013-1573-2. Epub 2013 Jan 29. Retraction in: Peng Z, Shuangzhu Y, Yongjie J, Xinjun Z, Ying L. Mol Cell Biochem. 2016 Apr;415(1-2):207.


miR-146a promotes Borna disease virus 1 replication through IRAK1/TRAF6/NF-κB signaling pathway.

Zhang X, Guo Y, Xu X, Tang T, Sun L, Wang H, Zhou W, Fang L, Li Q, Xie P.

Virus Res. 2019 Oct 2;271:197671. doi: 10.1016/j.virusres.2019.197671. Epub 2019 Jul 19.


Integrin-linked kinase overexpression promotes epithelial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells.

Shen H, Ma JL, Zhang Y, Deng GL, Qu YL, Wu XL, He JX, Zhang S, Zeng S.

World J Gastroenterol. 2016 Apr 21;22(15):3969-77. doi: 10.3748/wjg.v22.i15.3969.


Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21.

Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, Li H, Guo B, Zhu Q, Wei Q, Moyer MP, Wang P, Cai S, Goel A, Qin H, Ma Y.

Gastroenterology. 2017 Mar;152(4):851-866.e24. doi: 10.1053/j.gastro.2016.11.018. Epub 2016 Nov 19.


[Effect of TRAF6 Downregulation on Malignant Biological Behavior of
Lung Cancer Cell Lines].

Lin G, Huang C, Su G, Hu H, Xu H, Huang C.

Zhongguo Fei Ai Za Zhi. 2015 Nov;18(11):661-7. doi: 10.3779/j.issn.1009-3419.2015.11.01. Chinese.


siRNA-induced TRAF6 knockdown promotes the apoptosis and inhibits the invasion of human lung cancer SPC-A1 cells.

He Z, Huang C, Lin G, Ye Y.

Oncol Rep. 2016 Apr;35(4):1933-40. doi: 10.3892/or.2016.4602. Epub 2016 Feb 1.


Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-κB in vitro and in vivo.

Tang W, Su G, Li J, Liao J, Chen S, Huang C, Liu F, Chen Q, Ye Y.

Int J Oncol. 2014 Sep;45(3):995-1010. doi: 10.3892/ijo.2014.2513. Epub 2014 Jun 23.


Downregulation of SAFB Sustains the NF-κB Pathway by Targeting TAK1 during the Progression of Colorectal Cancer.

Jiao HL, Ye YP, Yang RW, Sun HY, Wang SY, Wang YX, Xiao ZY, He LQ, Cai JJ, Wei WT, Chen YR, Gu CC, Cai YL, Hu YT, Lai QH, Qiu JF, Liang L, Cao GW, Liao WT, Ding YQ.

Clin Cancer Res. 2017 Nov 15;23(22):7108-7118. doi: 10.1158/1078-0432.CCR-17-0747. Epub 2017 Sep 14.


TAB3 upregulates Survivin expression to promote colorectal cancer invasion and metastasis by binding to the TAK1-TRAF6 complex.

Luo C, Yuan R, Chen L, Zhou W, Shen W, Qiu Y, Shao J, Yan J, Shao J.

Oncotarget. 2017 Nov 18;8(63):106565-106576. doi: 10.18632/oncotarget.22497. eCollection 2017 Dec 5.


Effects of microRNA-146a on the proliferation and apoptosis of human osteoarthritis chondrocytes by targeting TRAF6 through the NF-κB signalling pathway.

Zhong JH, Li J, Liu CF, Liu N, Bian RX, Zhao SM, Yan SY, Zhang YB.

Biosci Rep. 2017 Apr 28;37(2). pii: BSR20160578. doi: 10.1042/BSR20160578. Print 2017 Apr 30.


Knockdown of PHF5A Inhibits Migration and Invasion of HCC Cells via Downregulating NF-κB Signaling.

Yang Q, Zhang J, Xu S, Jia C, Meng W, Tang H, Zhang X, Zhang Y, Fu B.

Biomed Res Int. 2019 Jan 15;2019:1621854. doi: 10.1155/2019/1621854. eCollection 2019.


Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway.

Wu DM, Han XR, Wen X, Wang S, Wang YJ, Shen M, Fan SH, Zhuang J, Zhang ZF, Shan Q, Li MQ, Hu B, Sun CH, Lu J, Zheng YL.

Cell Physiol Biochem. 2018;48(4):1563-1578. doi: 10.1159/000492279. Epub 2018 Aug 2.


Downregulation of miR-141-3p promotes bone metastasis via activating NF-κB signaling in prostate cancer.

Huang S, Wa Q, Pan J, Peng X, Ren D, Huang Y, Chen X, Tang Y.

J Exp Clin Cancer Res. 2017 Dec 4;36(1):173. doi: 10.1186/s13046-017-0645-7.


CSN5 silencing inhibits invasion and arrests cell cycle progression in human colorectal cancer SW480 and LS174T cells in vitro.

Zhong G, Li H, Shan T, Zhang N.

Int J Clin Exp Pathol. 2015 Mar 1;8(3):2809-15. eCollection 2015.


LPS Upregulated VEGFR-3 Expression Promote Migration and Invasion in Colorectal Cancer via a Mechanism of Increased NF-κB Binding to the Promoter of VEGFR-3.

Zhu G, Huang Q, Zheng W, Huang Y, Hua J, Yang S, Zhuang J, Wang J, Chang J, Xu J, Ye J.

Cell Physiol Biochem. 2016;39(5):1665-1678. Epub 2016 Sep 19.


H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells.

Maeda S, Yoshida H, Ogura K, Mitsuno Y, Hirata Y, Yamaji Y, Akanuma M, Shiratori Y, Omata M.

Gastroenterology. 2000 Jul;119(1):97-108.


Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis.

Chen H, Li M, Campbell RA, Burkhardt K, Zhu D, Li SG, Lee HJ, Wang C, Zeng Z, Gordon MS, Bonavida B, Berenson JR.

Oncogene. 2006 Oct 19;25(49):6520-7. Epub 2006 May 15.


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