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Items: 1 to 20 of 98

1.

Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A.

Zhao L, Zhang C, Cao G, Dong X, Li D, Jiang L.

Neurochem Res. 2019 Sep 4. doi: 10.1007/s11064-019-02868-4. [Epub ahead of print]

PMID:
31486012
2.

The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats.

Meng F, Li N, Li D, Song B, Li L.

Behav Brain Res. 2019 Aug 5;368:111902. doi: 10.1016/j.bbr.2019.111902. Epub 2019 Apr 10.

PMID:
30980850
3.
4.

Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus.

Dong P, Zhao J, Li N, Lu L, Li L, Zhang X, Yang B, Zhang L, Li D.

Behav Brain Res. 2018 Jul 16;347:325-331. doi: 10.1016/j.bbr.2018.03.031. Epub 2018 Mar 21.

PMID:
29574103
5.

Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease.

Li T, Gua C, Wu B, Chen Y.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):2071-2077. doi: 10.1016/j.bbrc.2017.12.069. Epub 2017 Dec 13.

PMID:
29247650
6.

Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ.

Zhang X, Li N, Lu L, Lin Q, Li L, Dong P, Yang B, Li D, Fei J.

Mol Med Rep. 2019 May;19(5):3815-3822. doi: 10.3892/mmr.2019.10052. Epub 2019 Mar 18.

PMID:
30896803
7.

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress.

Li T, Chen Y, Gua C, Li X.

Front Physiol. 2017 May 30;8:350. doi: 10.3389/fphys.2017.00350. eCollection 2017.

8.

Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice.

Li D, Ke Y, Zhan R, Liu C, Zhao M, Zeng A, Shi X, Ji L, Cheng S, Pan B, Zheng L, Hong H.

Aging Cell. 2018 Aug;17(4):e12768. doi: 10.1111/acel.12768. Epub 2018 May 10.

9.

Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function.

Fan H, Wu PF, Zhang L, Hu ZL, Wang W, Guan XL, Luo H, Ni M, Yang JW, Li MX, Chen JG, Wang F.

Antioxid Redox Signal. 2015 Apr 1;22(10):832-47. doi: 10.1089/ars.2014.6022. Epub 2015 Feb 26.

10.

Gut microbial metabolite TMAO contributes to renal dysfunction in a mouse model of diet-induced obesity.

Sun G, Yin Z, Liu N, Bian X, Yu R, Su X, Zhang B, Wang Y.

Biochem Biophys Res Commun. 2017 Nov 18;493(2):964-970. doi: 10.1016/j.bbrc.2017.09.108. Epub 2017 Sep 20.

PMID:
28942145
11.

Sevoflurane Induces Exaggerated and Persistent Cognitive Decline in a Type II Diabetic Rat Model by Aggregating Hippocampal Inflammation.

Li D, Liu L, Li L, Li X, Huang B, Zhou C, Zhang Z, Wang C, Dong P, Zhang X, Yang B, Zhang L.

Front Pharmacol. 2017 Nov 29;8:886. doi: 10.3389/fphar.2017.00886. eCollection 2017.

12.
13.

Hypermethylation of Hippocampal Synaptic Plasticity-Related genes is Involved in Neonatal Sevoflurane Exposure-Induced Cognitive Impairments in Rats.

Ju LS, Jia M, Sun J, Sun XR, Zhang H, Ji MH, Yang JJ, Wang ZY.

Neurotox Res. 2016 Feb;29(2):243-55. doi: 10.1007/s12640-015-9585-1. Epub 2015 Dec 17.

PMID:
26678494
14.

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress.

Ke Y, Li D, Zhao M, Liu C, Liu J, Zeng A, Shi X, Cheng S, Pan B, Zheng L, Hong H.

Free Radic Biol Med. 2018 Feb 20;116:88-100. doi: 10.1016/j.freeradbiomed.2018.01.007. Epub 2018 Jan 8. Erratum in: Free Radic Biol Med. 2018 Dec;129:608-610.

PMID:
29325896
15.

Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice.

Chen K, Zheng X, Feng M, Li D, Zhang H.

Front Physiol. 2017 Mar 21;8:139. doi: 10.3389/fphys.2017.00139. eCollection 2017.

16.

Learning, memory and synaptic plasticity in hippocampus in rats exposed to sevoflurane.

Xiao H, Liu B, Chen Y, Zhang J.

Int J Dev Neurosci. 2016 Feb;48:38-49. doi: 10.1016/j.ijdevneu.2015.11.001. Epub 2015 Dec 2.

PMID:
26612208
17.
18.

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome.

Sun X, Jiao X, Ma Y, Liu Y, Zhang L, He Y, Chen Y.

Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):63-70. doi: 10.1016/j.bbrc.2016.11.017. Epub 2016 Nov 8.

PMID:
27833015
20.

Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota.

Chen ML, Yi L, Zhang Y, Zhou X, Ran L, Yang J, Zhu JD, Zhang QY, Mi MT.

MBio. 2016 Apr 5;7(2):e02210-15. doi: 10.1128/mBio.02210-15.

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