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Items: 1 to 20 of 90

1.

Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank.

Meng W, Adams MJ, Palmer CNA; 23andMe Research Team, Shi J, Auton A, Ryan KA, Jordan JM, Mitchell BD, Jackson RD, Yau MS, McIntosh AM, Smith BH.

Commun Biol. 2019 Aug 28;2:321. doi: 10.1038/s42003-019-0568-2. eCollection 2019.

2.

Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians.

Yau MS, Yerges-Armstrong LM, Liu Y, Lewis CE, Duggan DJ, Renner JB, Torner J, Felson DT, McCulloch CE, Kwoh CK, Nevitt MC, Hochberg MC, Mitchell BD, Jordan JM, Jackson RD.

Arthritis Rheumatol. 2017 Feb;69(2):343-351. doi: 10.1002/art.39932.

3.

Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans.

Liu Y, Yau MS, Yerges-Armstrong LM, Duggan DJ, Renner JB, Hochberg MC, Mitchell BD, Jackson RD, Jordan JM.

J Rheumatol. 2017 Nov;44(11):1652-1658. doi: 10.3899/jrheum.161488. Epub 2017 Sep 15.

4.

A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand.

Zhang R, Yao J, Xu P, Ji B, Luck JV, Chin B, Lu S, Kelsoe JR, Ma J.

Inflamm Res. 2015 Jun;64(6):405-14. doi: 10.1007/s00011-015-0818-9. Epub 2015 Apr 17. Review.

PMID:
25894512
5.

Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5.

Hatzikotoulas K, Roposch A; DDH Case Control Consortium, Shah KM, Clark MJ, Bratherton S, Limbani V, Steinberg J, Zengini E, Warsame K, Ratnayake M, Tselepi M, Schwartzentruber J, Loughlin J, Eastwood DM, Zeggini E, Wilkinson JM.

Commun Biol. 2018 May 31;1:56. doi: 10.1038/s42003-018-0052-4. eCollection 2018.

6.

Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study.

Vaes RB, Rivadeneira F, Kerkhof JM, Hofman A, Pols HA, Uitterlinden AG, van Meurs JB.

Ann Rheum Dis. 2009 Nov;68(11):1754-60. doi: 10.1136/ard.2008.099655. Epub 2008 Nov 24.

PMID:
19029166
7.

Association analysis of BMD-associated SNPs with knee osteoarthritis.

Yerges-Armstrong LM, Yau MS, Liu Y, Krishnan S, Renner JB, Eaton CB, Kwoh CK, Nevitt MC, Duggan DJ, Mitchell BD, Jordan JM, Hochberg MC, Jackson RD.

J Bone Miner Res. 2014 Jun;29(6):1373-9. doi: 10.1002/jbmr.2160.

8.

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Soler Artigas M, Billington CK, Kheirallah AK, Allen R, Cook JP, Probert K, Obeidat M, Bossé Y, Hao K, Postma DS, Paré PD, Ramasamy A; UK Brain Expression Consortium (UKBEC), Mägi R, Mihailov E, Reinmaa E, Melén E, O'Connell J, Frangou E, Delaneau O; OxGSK Consortium, Freeman C, Petkova D, McCarthy M, Sayers I, Deloukas P, Hubbard R, Pavord I, Hansell AL, Thomson NC, Zeggini E, Morris AP, Marchini J, Strachan DP, Tobin MD, Hall IP.

Lancet Respir Med. 2015 Oct;3(10):769-81. doi: 10.1016/S2213-2600(15)00283-0. Epub 2015 Sep 27. Erratum in: Lancet Respir Med. 2016 Jan;4(1):e4. Erratum in: Lancet Respir Med. 2016 Jan;4(1):e4.

9.

Racial differences in self-reported pain and function among individuals with radiographic hip and knee osteoarthritis: the Johnston County Osteoarthritis Project.

Allen KD, Helmick CG, Schwartz TA, DeVellis RF, Renner JB, Jordan JM.

Osteoarthritis Cartilage. 2009 Sep;17(9):1132-6. doi: 10.1016/j.joca.2009.03.003. Epub 2009 Mar 18.

10.

A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773).

Meng W, Adams MJ, Hebert HL, Deary IJ, McIntosh AM, Smith BH.

EBioMedicine. 2018 Feb;28:180-186. doi: 10.1016/j.ebiom.2018.01.023. Epub 2018 Jan 31.

11.

Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations.

Valdes AM, Spector TD, Doherty S, Wheeler M, Hart DJ, Doherty M.

Ann Rheum Dis. 2009 Dec;68(12):1916-20. doi: 10.1136/ard.2008.102236. Epub 2008 Dec 3.

PMID:
19054821
12.

Knee pain and knee osteoarthritis severity in self-reported task specific disability: the Johnston County Osteoarthritis Project.

Jordan J, Luta G, Renner J, Dragomir A, Hochberg M, Fryer J.

J Rheumatol. 1997 Jul;24(7):1344-9.

PMID:
9228135
13.

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand.

Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gómez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Näkki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP.

Arthritis Rheum. 2009 Jun;60(6):1710-21. doi: 10.1002/art.24524.

14.

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.

Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, Roenneberg T, Wilson JF, Del Greco F, Hicks AA, Shin C, Yun CH, Lee SK, Metspalu A, Byrne EM, Gehrman PR, Tiemeier H, Allebrandt KV, Freathy RM, Murray A, Hinds DA, Frayling TM, Weedon MN.

PLoS Genet. 2016 Aug 5;12(8):e1006125. doi: 10.1371/journal.pgen.1006125. eCollection 2016 Aug.

15.

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.

Reynard LN, Bui C, Canty-Laird EG, Young DA, Loughlin J.

Hum Mol Genet. 2011 Sep 1;20(17):3450-60. doi: 10.1093/hmg/ddr253. Epub 2011 Jun 3.

PMID:
21642387
16.

Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis.

Pregizer SK, Kiapour AM, Young M, Chen H, Schoor M, Liu Z, Cao J, Rosen V, Capellini TD.

Ann Rheum Dis. 2018 Mar;77(3):450. doi: 10.1136/annrheumdis-2017-212475. Epub 2018 Jan 8.

17.

Annual Incidence of Knee Symptoms and Four Knee Osteoarthritis Outcomes in the Johnston County Osteoarthritis Project.

Murphy LB, Moss S, Do BT, Helmick CG, Schwartz TA, Barbour KE, Renner J, Kalsbeek W, Jordan JM.

Arthritis Care Res (Hoboken). 2016 Jan;68(1):55-65. doi: 10.1002/acr.22641.

18.

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

arcOGEN Consortium; arcOGEN Collaborators, Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O'Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD, Loughlin J.

Lancet. 2012 Sep 1;380(9844):815-23. doi: 10.1016/S0140-6736(12)60681-3. Epub 2012 Jul 3.

19.

A novel variant in GLIS3 is associated with osteoarthritis.

Casalone E, Tachmazidou I, Zengini E, Hatzikotoulas K, Hackinger S, Suveges D, Steinberg J, Rayner NW; arcOGEN Consortium, Wilkinson JM, Panoutsopoulou K, Zeggini E.

Ann Rheum Dis. 2018 Apr;77(4):620-623. doi: 10.1136/annrheumdis-2017-211848. Epub 2018 Feb 7.

20.

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility.

Chapman K, Takahashi A, Meulenbelt I, Watson C, Rodriguez-Lopez J, Egli R, Tsezou A, Malizos KN, Kloppenburg M, Shi D, Southam L, van der Breggen R, Donn R, Qin J, Doherty M, Slagboom PE, Wallis G, Kamatani N, Jiang Q, Gonzalez A, Loughlin J, Ikegawa S.

Hum Mol Genet. 2008 May 15;17(10):1497-504. doi: 10.1093/hmg/ddn038. Epub 2008 Feb 24.

PMID:
18299287

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