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Items: 1 to 20 of 96

1.

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.

Zhong W, Pasunooti KK, Balamkundu S, Wong YH, Nah Q, Gadi V, Gnanakalai S, Chionh YH, McBee ME, Gopal P, Lim SH, Olivier N, Buurman ET, Dick T, Liu CF, Lescar J, Dedon PC.

J Med Chem. 2019 Sep 12;62(17):7788-7805. doi: 10.1021/acs.jmedchem.9b00582. Epub 2019 Aug 29.

2.

Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa.

Li Y, Zhong W, Koay AZ, Ng HQ, Nah Q, Wong YH, Hill J, Lescar J, Dedon PC, Kang C.

Biomol NMR Assign. 2019 Oct;13(2):327-332. doi: 10.1007/s12104-019-09900-2. Epub 2019 Jun 7.

PMID:
31175551
3.

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.

Zhong W, Koay A, Ngo A, Li Y, Nah Q, Wong YH, Chionh YH, Ng HQ, Koh-Stenta X, Poulsen A, Foo K, McBee M, Choong ML, El Sahili A, Kang C, Matter A, Lescar J, Hill J, Dedon P.

ACS Infect Dis. 2019 Mar 8;5(3):326-335. doi: 10.1021/acsinfecdis.8b00275. Epub 2019 Feb 4.

PMID:
30682246
4.

Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa.

Jaroensuk J, Wong YH, Zhong W, Liew CW, Maenpuen S, Sahili AE, Atichartpongkul S, Chionh YH, Nah Q, Thongdee N, McBee ME, Prestwich EG, DeMott MS, Chaiyen P, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M.

RNA. 2019 Nov;25(11):1481-1496. doi: 10.1261/rna.066746.118. Epub 2019 Aug 9.

PMID:
31399541
5.

Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase.

Li Y, Zhong W, Koay AZ, Ng HQ, Koh-Stenta X, Nah Q, Lim SH, Larsson A, Lescar J, Hill J, Dedon PC, Kang C.

Biomol NMR Assign. 2019 Apr;13(1):49-53. doi: 10.1007/s12104-018-9849-9. Epub 2018 Oct 8.

PMID:
30298375
6.

Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.

Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET.

J Med Chem. 2013 Sep 26;56(18):7278-88. doi: 10.1021/jm400718n. Epub 2013 Sep 17.

PMID:
23981144
7.

Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.

Ito T, Masuda I, Yoshida K, Goto-Ito S, Sekine S, Suh SW, Hou YM, Yokoyama S.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4197-205. doi: 10.1073/pnas.1422981112. Epub 2015 Jul 16.

8.

Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition.

Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK.

EMBO J. 2003 Jun 2;22(11):2593-603.

9.

The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from Aquifex aeolicus.

Takeda H, Toyooka T, Ikeuchi Y, Yokobori S, Okadome K, Takano F, Oshima T, Suzuki T, Endo Y, Hori H.

Genes Cells. 2006 Dec;11(12):1353-65.

10.

Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3',5'-cAMP in Bacteria.

Zhang Y, Agrebi R, Bellows LE, Collet JF, Kaever V, Gründling A.

J Biol Chem. 2017 Jan 6;292(1):313-327. doi: 10.1074/jbc.M116.758896. Epub 2016 Nov 23.

11.

Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.

Whitehouse AJ, Thomas SE, Brown KP, Fanourakis A, Chan DS, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG.

J Med Chem. 2019 Aug 8;62(15):7210-7232. doi: 10.1021/acs.jmedchem.9b00809. Epub 2019 Jul 19.

12.

Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein.

Brulé H, Elliott M, Redlak M, Zehner ZE, Holmes WM.

Biochemistry. 2004 Jul 20;43(28):9243-55.

PMID:
15248782
13.

TrmD: A Methyl Transferase for tRNA Methylation With m1G37.

Hou YM, Matsubara R, Takase R, Masuda I, Sulkowska JI.

Enzymes. 2017;41:89-115. doi: 10.1016/bs.enz.2017.03.003. Epub 2017 Apr 12. Review.

14.

Recognition of guanosine by dissimilar tRNA methyltransferases.

Sakaguchi R, Giessing A, Dai Q, Lahoud G, Liutkeviciute Z, Klimasauskas S, Piccirilli J, Kirpekar F, Hou YM.

RNA. 2012 Sep;18(9):1687-701. doi: 10.1261/rna.032029.111. Epub 2012 Jul 30.

15.

The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD).

Masuda I, Sakaguchi R, Liu C, Gamper H, Hou YM.

J Biol Chem. 2013 Oct 4;288(40):28987-96. doi: 10.1074/jbc.M113.485797. Epub 2013 Aug 28.

16.

Trm5 and TrmD: Two Enzymes from Distinct Origins Catalyze the Identical tRNA Modification, m¹G37.

Goto-Ito S, Ito T, Yokoyama S.

Biomolecules. 2017 Mar 21;7(1). pii: E32. doi: 10.3390/biom7010032. Review.

17.

Differentiating analogous tRNA methyltransferases by fragments of the methyl donor.

Lahoud G, Goto-Ito S, Yoshida K, Ito T, Yokoyama S, Hou YM.

RNA. 2011 Jul;17(7):1236-46. doi: 10.1261/rna.2706011. Epub 2011 May 20.

18.

Control of catalytic cycle by a pair of analogous tRNA modification enzymes.

Christian T, Lahoud G, Liu C, Hou YM.

J Mol Biol. 2010 Jul 9;400(2):204-17. doi: 10.1016/j.jmb.2010.05.003. Epub 2010 May 7.

19.

Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases.

Christian T, Hou YM.

J Mol Biol. 2007 Oct 26;373(3):623-32. Epub 2007 Aug 21.

20.

Ligand-mediated anticodon conformational changes occur during tRNA methylation by a TrmD methyltransferase.

Watts JM, Gabruzsk J, Holmes WM.

Biochemistry. 2005 May 3;44(17):6629-39.

PMID:
15850396

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