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Items: 1 to 20 of 97

1.

MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma.

Li B, Yan J, Phyu T, Fan S, Chung TH, Mustafa NB, Lin B, Wang L, Eichhorn PJA, Goh BC, Ng SB, Kappei D, Chng WJ.

Blood. 2019 Aug 21. pii: blood.2019000381. doi: 10.1182/blood.2019000381. [Epub ahead of print]

PMID:
31434700
2.

EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity.

Yan J, Ng SB, Tay JL, Lin B, Koh TL, Tan J, Selvarajan V, Liu SC, Bi C, Wang S, Choo SN, Shimizu N, Huang G, Yu Q, Chng WJ.

Blood. 2013 May 30;121(22):4512-20. doi: 10.1182/blood-2012-08-450494. Epub 2013 Mar 25.

PMID:
23529930
3.

EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma.

Yan J, Li B, Lin B, Lee PT, Chung TH, Tan J, Bi C, Lee XT, Selvarajan V, Ng SB, Yang H, Yu Q, Chng WJ.

Blood. 2016 Aug 18;128(7):948-58. doi: 10.1182/blood-2016-01-690701. Epub 2016 Jun 13.

PMID:
27297789
4.

EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner.

Kim SH, Joshi K, Ezhilarasan R, Myers TR, Siu J, Gu C, Nakano-Okuno M, Taylor D, Minata M, Sulman EP, Lee J, Bhat KP, Salcini AE, Nakano I.

Stem Cell Reports. 2015 Feb 10;4(2):226-38. doi: 10.1016/j.stemcr.2014.12.006. Epub 2015 Jan 15.

5.

Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling.

Ng SB, Selvarajan V, Huang G, Zhou J, Feldman AL, Law M, Kwong YL, Shimizu N, Kagami Y, Aozasa K, Salto-Tellez M, Chng WJ.

J Pathol. 2011 Mar;223(4):496-510. doi: 10.1002/path.2823. Epub 2011 Jan 5.

PMID:
21294123
6.

RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC.

Selvarajan V, Osato M, Nah GSS, Yan J, Chung TH, Voon DC, Ito Y, Ham MF, Salto-Tellez M, Shimizu N, Choo SN, Fan S, Chng WJ, Ng SB.

Leukemia. 2017 Oct;31(10):2219-2227. doi: 10.1038/leu.2017.40. Epub 2017 Jan 25.

7.

Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/T-cell lymphoma but shows distinctive stem cell-like phenotype.

Ng SB, Ohshima K, Selvarajan V, Huang G, Choo SN, Miyoshi H, Shimizu N, Reghunathan R, Chua HC, Yeoh AE, Quah TC, Koh LP, Tan PL, Chng WJ.

Leuk Lymphoma. 2015;56(8):2408-15. doi: 10.3109/10428194.2014.983099. Epub 2015 Jan 21.

PMID:
25382618
8.

MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation.

Liu H, Sun Q, Sun Y, Zhang J, Yuan H, Pang S, Qi X, Wang H, Zhang M, Zhang H, Yu C, Gu C.

Mol Cancer Res. 2017 Sep;15(9):1275-1286. doi: 10.1158/1541-7786.MCR-17-0105. Epub 2017 May 23.

9.

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma.

Song TL, Nairismägi ML, Laurensia Y, Lim JQ, Tan J, Li ZM, Pang WL, Kizhakeyil A, Wijaya GC, Huang DC, Nagarajan S, Chia BK, Cheah D, Liu YH, Zhang F, Rao HL, Tang T, Wong EK, Bei JX, Iqbal J, Grigoropoulos NF, Ng SB, Chng WJ, Teh BT, Tan SY, Verma NK, Fan H, Lim ST, Ong CK.

Blood. 2018 Sep 13;132(11):1146-1158. doi: 10.1182/blood-2018-01-829424. Epub 2018 Jul 27.

10.

EZH2 Phosphorylation Promotes Self-Renewal of Glioma Stem-Like Cells Through NF-κB Methylation.

Liu H, Sun Y, Qi X, Gordon RE, O'Brien JA, Yuan H, Zhang J, Wang Z, Zhang M, Song Y, Yu C, Gu C.

Front Oncol. 2019 Jul 16;9:641. doi: 10.3389/fonc.2019.00641. eCollection 2019.

11.

MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.

Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I.

Stem Cells. 2013 Jun;31(6):1051-63. doi: 10.1002/stem.1358.

12.

Dysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphoma.

Ng SB, Yan J, Huang G, Selvarajan V, Tay JL, Lin B, Bi C, Tan J, Kwong YL, Shimizu N, Aozasa K, Chng WJ.

Blood. 2011 Nov 3;118(18):4919-29. doi: 10.1182/blood-2011-07-364224. Epub 2011 Sep 14. Erratum in: Blood. 2014 Jan 9;123(2):302.

PMID:
21921041
13.

Positron emission tomography/computed tomography in the diagnosis, staging, and prognostic evaluation of natural killer/T-cell lymphoma.

Ding JJ, Chen YL, Zhou SH, Zhao K.

J Int Med Res. 2018 Dec;46(12):4920-4929. doi: 10.1177/0300060518804375. Epub 2018 Oct 17. Review.

14.

Extranodal nasal-type NK/T-cell lymphoma: computed tomography findings of head and neck involvement.

Kim J, Kim EY, Lee SK, Kim DI, Kim CH, Kim SH, Choi EC.

Acta Radiol. 2010 Mar;51(2):164-9. doi: 10.3109/02841850903476572.

PMID:
20092373
15.

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.

Beke L, Kig C, Linders JT, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson CN, Beullens M, Brehmer D, Bollen M.

Biosci Rep. 2015 Oct 2;35(6). pii: e00267. doi: 10.1042/BSR20150194. Erratum in: Biosci Rep. 2018 Nov 30;38(6):.

16.

CDK5/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion.

Jin X, Yang C, Fan P, Xiao J, Zhang W, Zhan S, Liu T, Wang D, Wu H.

J Biol Chem. 2017 Apr 14;292(15):6269-6280. doi: 10.1074/jbc.M116.764407. Epub 2017 Feb 27.

17.

Variable clinical presentations of nasal and Waldeyer ring natural killer/T-cell lymphoma.

Li YX, Liu QF, Fang H, Qi SN, Wang H, Wang WH, Song YW, Lu J, Jin J, Wang SL, Liu YP, Lu N, Liu XF, Yu ZH.

Clin Cancer Res. 2009 Apr 15;15(8):2905-12. doi: 10.1158/1078-0432.CCR-08-2914. Epub 2009 Mar 24.

18.

SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.

Lu W, Liu S, Li B, Xie Y, Izban MG, Ballard BR, Sathyanarayana SA, Adunyah SE, Matusik RJ, Chen Z.

Oncogene. 2017 Mar;36(10):1364-1373. doi: 10.1038/onc.2016.300. Epub 2016 Nov 21.

19.

Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma.

Bolomsky A, Heusschen R, Schlangen K, Stangelberger K, Muller J, Schreiner W, Zojer N, Caers J, Ludwig H.

Haematologica. 2018 Feb;103(2):325-335. doi: 10.3324/haematol.2017.172973. Epub 2017 Nov 9.

20.

Isolated Extranodal Natural Killer T-Cell Lymphoma of the Orbit in a Young Patient: Complete Regression with the SMILE Regimen.

Meel R, Dhiman R, Wadhwani M, Kashyap S, Sharma S, Gogia A.

Ocul Oncol Pathol. 2017 Jan;3(1):45-48. doi: 10.1159/000449227. Epub 2016 Sep 30.

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