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A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites.

McCormick B, Craig HE, Chu JY, Carlin LM, Canel M, Wollweber F, Toivakka M, Michael M, Astier AL, Norton L, Lilja J, Felton JM, Sasaki T, Ivaska J, Hers I, Dransfield I, Rossi AG, Vermeren S.

J Immunol. 2019 Sep 15;203(6):1579-1588. doi: 10.4049/jimmunol.1900443. Epub 2019 Aug 19.


Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.

Gambardella L, Anderson KE, Jakus Z, Kovács M, Voigt S, Hawkins PT, Stephens L, Mócsai A, Vermeren S.

J Immunol. 2013 Jan 1;190(1):381-91. doi: 10.4049/jimmunol.1201330. Epub 2012 Nov 23.


The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils.

Gambardella L, Anderson KE, Nussbaum C, Segonds-Pichon A, Margarido T, Norton L, Ludwig T, Sperandio M, Hawkins PT, Stephens L, Vermeren S.

Blood. 2011 Jul 28;118(4):1087-98. doi: 10.1182/blood-2010-10-312959. Epub 2011 Apr 13.


Tetraspanin CD37 Regulates β2 Integrin-Mediated Adhesion and Migration in Neutrophils.

Wee JL, Schulze KE, Jones EL, Yeung L, Cheng Q, Pereira CF, Costin A, Ramm G, van Spriel AB, Hickey MJ, Wright MD.

J Immunol. 2015 Dec 15;195(12):5770-9. doi: 10.4049/jimmunol.1402414. Epub 2015 Nov 13.


Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration.

Xu W, Wang P, Petri B, Zhang Y, Tang W, Sun L, Kress H, Mann T, Shi Y, Kubes P, Wu D.

Immunity. 2010 Sep 24;33(3):340-50. doi: 10.1016/j.immuni.2010.08.015.


Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways.

Futosi K, Fodor S, Mócsai A.

Int Immunopharmacol. 2013 Dec;17(4):1185-97. doi: 10.1016/j.intimp.2013.11.010. Epub 2013 Nov 18. Review.


Neutrophil cell surface receptors and their intracellular signal transduction pathways.

Futosi K, Fodor S, Mócsai A.

Int Immunopharmacol. 2013 Nov;17(3):638-50. doi: 10.1016/j.intimp.2013.06.034. Epub 2013 Aug 30. Review.


HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1.

Latasiewicz J, Artz A, Jing D, Blanco MP, Currie SM, Avila MV, Schnoor M, Vestweber D.

J Leukoc Biol. 2017 May;101(5):1133-1142. doi: 10.1189/jlb.1A0416-195R. Epub 2017 Jan 25.


Soluble CD40 ligand stimulates CD40-dependent activation of the β2 integrin Mac-1 and protein kinase C zeda (PKCζ) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst.

Jin R, Yu S, Song Z, Zhu X, Wang C, Yan J, Wu F, Nanda A, Granger DN, Li G.

PLoS One. 2013 Jun 6;8(6):e64631. doi: 10.1371/journal.pone.0064631. Print 2013.


ARAP3 functions in hematopoietic stem cells.

Song Y, Jiang J, Vermeren S, Tong W.

PLoS One. 2014 Dec 26;9(12):e116107. doi: 10.1371/journal.pone.0116107. eCollection 2014.


The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.

Raaijmakers JH, Deneubourg L, Rehmann H, de Koning J, Zhang Z, Krugmann S, Erneux C, Bos JL.

Cell Signal. 2007 Jun;19(6):1249-57. Epub 2007 Jan 20.


ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.

I ST, Nie Z, Stewart A, Najdovska M, Hall NE, He H, Randazzo PA, Lock P.

J Cell Sci. 2004 Dec 1;117(Pt 25):6071-84. Epub 2004 Nov 16.


Neutrophils rapidly transit inflamed lymphatic vessel endothelium via integrin-dependent proteolysis and lipoxin-induced junctional retraction.

Rigby DA, Ferguson DJ, Johnson LA, Jackson DG.

J Leukoc Biol. 2015 Dec;98(6):897-912. doi: 10.1189/jlb.1HI0415-149R. Epub 2015 Jul 27.


PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.

Gambardella L, Hemberger M, Hughes B, Zudaire E, Andrews S, Vermeren S.

Sci Signal. 2010 Oct 26;3(145):ra76. doi: 10.1126/scisignal.2001026.


GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.

Leyme A, Marivin A, Garcia-Marcos M.

J Biol Chem. 2016 Apr 8;291(15):8269-82. doi: 10.1074/jbc.M115.691550. Epub 2016 Feb 17.


The role of kindlin in neutrophil recruitment to inflammatory sites.

Stadtmann A, Zarbock A.

Curr Opin Hematol. 2017 Jan;24(1):38-45. Review.


Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation.

Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J.

Blood. 2013 May 9;121(19):3789-800, S1-15. doi: 10.1182/blood-2012-11-467985. Epub 2013 Mar 4.


ARAP3 is essential for formation of lamellipodia after growth factor stimulation.

Krugmann S, Andrews S, Stephens L, Hawkins PT.

J Cell Sci. 2006 Feb 1;119(Pt 3):425-32. Epub 2006 Jan 17.


c-Abl tyrosine kinase plays a critical role in β2 integrin-dependent neutrophil migration by regulating Vav1 activity.

Tong H, Zhao B, Shi H, Ba X, Wang X, Jiang Y, Zeng X.

J Leukoc Biol. 2013 Apr;93(4):611-22. doi: 10.1189/jlb.1012487. Epub 2013 Jan 16.


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