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Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.

Wang W, Wang M, Ruan Y, Tan J, Wang H, Yang T, Li J, Zhou Q.

J Agric Food Chem. 2019 Sep 11;67(36):10097-10106. doi: 10.1021/acs.jafc.9b04178. Epub 2019 Aug 30.


Mst1 promotes cardiac ischemia-reperfusion injury by inhibiting the ERK-CREB pathway and repressing FUNDC1-mediated mitophagy.

Yu W, Xu M, Zhang T, Zhang Q, Zou C.

J Physiol Sci. 2019 Jan;69(1):113-127. doi: 10.1007/s12576-018-0627-3. Epub 2018 Jun 30.


BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.

Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, Kim T, Sussman MA, Gustafsson ÅB.

Autophagy. 2019 Jul;15(7):1182-1198. doi: 10.1080/15548627.2019.1580095. Epub 2019 Feb 22.


Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy.

Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L, Chen Q.

Autophagy. 2016;12(4):689-702. doi: 10.1080/15548627.2016.1151580.


Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.

Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, Huang L, Xue P, Li B, Wang X, Jin H, Wang J, Yang F, Liu P, Zhu Y, Sui S, Chen Q.

Nat Cell Biol. 2012 Jan 22;14(2):177-85. doi: 10.1038/ncb2422.


Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy.

Chen Z, Liu L, Cheng Q, Li Y, Wu H, Zhang W, Wang Y, Sehgal SA, Siraj S, Wang X, Wang J, Zhu Y, Chen Q.

EMBO Rep. 2017 Mar;18(3):495-509. doi: 10.15252/embr.201643309. Epub 2017 Jan 19.


Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.

Wu S, Lu Q, Ding Y, Wu Y, Qiu Y, Wang P, Mao X, Huang K, Xie Z, Zou MH.

Circulation. 2019 Apr 16;139(16):1913-1936. doi: 10.1161/CIRCULATIONAHA.118.033552.


Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.

Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L, Chen Q.

Autophagy. 2019 Nov;15(11):1882-1898. doi: 10.1080/15548627.2019.1596482. Epub 2019 Apr 6.


ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy.

Wu W, Tian W, Hu Z, Chen G, Huang L, Li W, Zhang X, Xue P, Zhou C, Liu L, Zhu Y, Zhang X, Li L, Zhang L, Sui S, Zhao B, Feng D.

EMBO Rep. 2014 May;15(5):566-75. doi: 10.1002/embr.201438501. Epub 2014 Mar 26.


Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury.

Zhang W, Siraj S, Zhang R, Chen Q.

Autophagy. 2017 Jun 3;13(6):1080-1081. doi: 10.1080/15548627.2017.1300224. Epub 2017 Mar 21.


Mechanism for ginkgolic acid (15 : 1)-induced MDCK cell necrosis: Mitochondria and lysosomes damages and cell cycle arrest.

Yao QQ, Liu ZH, Xu MC, Hu HH, Zhou H, Jiang HD, Yu LS, Zeng S.

Chin J Nat Med. 2017 May;15(5):375-383. doi: 10.1016/S1875-5364(17)30058-4.


MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy.

Chen Z, Siraj S, Liu L, Chen Q.

Autophagy. 2017 Jul 3;13(7):1244-1245. doi: 10.1080/15548627.2017.1310789. Epub 2017 May 9.


FUNDC1-mediated mitophagy in bovine papillomavirus-infected urothelial cells.

Roperto S, Russo V, De Falco F, Rosati A, Catoi C, Roperto F.

Vet Microbiol. 2019 Jul;234:51-60. doi: 10.1016/j.vetmic.2019.05.017. Epub 2019 May 24.


NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α.

Zhou H, Wang J, Zhu P, Zhu H, Toan S, Hu S, Ren J, Chen Y.

Basic Res Cardiol. 2018 May 9;113(4):23. doi: 10.1007/s00395-018-0682-1.


Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury.

Zhou H, Zhu P, Guo J, Hu N, Wang S, Li D, Hu S, Ren J, Cao F, Chen Y.

Redox Biol. 2017 Oct;13:498-507. doi: 10.1016/j.redox.2017.07.007. Epub 2017 Jul 13.


Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.

Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM.

Sci Signal. 2018 Jun 26;11(536). pii: eaam5855. doi: 10.1126/scisignal.aam5855.


MicroRNA-137 is a novel hypoxia-responsive microRNA that inhibits mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX.

Li W, Zhang X, Zhuang H, Chen HG, Chen Y, Tian W, Wu W, Li Y, Wang S, Zhang L, Chen Y, Li L, Zhao B, Sui S, Hu Z, Feng D.

J Biol Chem. 2014 Apr 11;289(15):10691-701. doi: 10.1074/jbc.M113.537050. Epub 2014 Feb 26.


FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy.

Wu W, Li W, Chen H, Jiang L, Zhu R, Feng D.

Autophagy. 2016 Sep;12(9):1675-6. doi: 10.1080/15548627.2016.1193656. Epub 2016 Jun 17.


FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, Zhuang H, Zhang X, Chen H, Li S, Yang Y, Lu Y, Wang J, Zhu R, Zhang L, Sui S, Tan N, Zhao B, Zhang J, Li L, Feng D.

EMBO J. 2016 Jul 1;35(13):1368-84. doi: 10.15252/embj.201593102. Epub 2016 May 4.


Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.

Livingston MJ, Wang J, Zhou J, Wu G, Ganley IG, Hill JA, Yin XM, Dong Z.

Autophagy. 2019 May 22:1-21. doi: 10.1080/15548627.2019.1615822. [Epub ahead of print]


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