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Items: 1 to 20 of 100

1.

Indole-core-based novel antibacterial agent targeting FtsZ.

Yuan W, Yu Z, Song W, Li Y, Fang Z, Zhu B, Li X, Wang H, Hong W, Sun N.

Infect Drug Resist. 2019 Jul 24;12:2283-2296. doi: 10.2147/IDR.S208757. eCollection 2019.

2.

A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity.

Sun N, Lu YJ, Chan FY, Du RL, Zheng YY, Zhang K, So LY, Abagyan R, Zhuo C, Leung YC, Wong KY.

Front Microbiol. 2017 May 11;8:855. doi: 10.3389/fmicb.2017.00855. eCollection 2017.

3.

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics.

Wang J, Galgoci A, Kodali S, Herath KB, Jayasuriya H, Dorso K, Vicente F, González A, Cully D, Bramhill D, Singh S.

J Biol Chem. 2003 Nov 7;278(45):44424-8. Epub 2003 Sep 2.

4.

Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ.

Zheng YY, Du RL, Cai SY, Liu ZH, Fang ZY, Liu T, So LY, Lu YJ, Sun N, Wong KY.

Front Microbiol. 2018 Aug 17;9:1937. doi: 10.3389/fmicb.2018.01937. eCollection 2018.

5.

Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action.

Sun N, Du RL, Zheng YY, Huang BH, Guo Q, Zhang RF, Wong KY, Lu YJ.

Eur J Med Chem. 2017 Jul 28;135:1-11. doi: 10.1016/j.ejmech.2017.04.018. Epub 2017 Apr 15.

PMID:
28426995
6.

Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains.

Bi F, Song D, Qin Y, Liu X, Teng Y, Zhang N, Zhang P, Zhang N, Ma S.

Bioorg Med Chem. 2019 Jul 15;27(14):3179-3193. doi: 10.1016/j.bmc.2019.06.010. Epub 2019 Jun 7.

PMID:
31200986
7.

Design, synthesis and antibacterial evaluation of 2,4-disubstituted-6-thiophenyl-pyrimidines.

Fang Z, Zheng S, Chan KF, Yuan W, Guo Q, Wu W, Lui HK, Lu Y, Leung YC, Chan TH, Wong KY, Sun N.

Eur J Med Chem. 2019 Jan 1;161:141-153. doi: 10.1016/j.ejmech.2018.10.039. Epub 2018 Oct 17.

PMID:
30347327
8.

A quinoline-based FtsZ inhibitor for the study of antimicrobial activity and synergistic effects with β-lactam antibiotics.

Fang Z, Ban L, Li Y, Yuan W, Liu Z, Liu T, Li X, Wong KY, Lu Y, Sun N, Yao X.

J Pharmacol Sci. 2018 Jul;137(3):283-289. doi: 10.1016/j.jphs.2018.07.005. Epub 2018 Jul 17.

9.

Probing the benzofuroquinolinium derivative as a potent antibacterial agent through the inhibition of FtsZ activity.

Sun N, Ban L, Li M, Fang Z, Li X, Yao W, Pan J, Lu Y, Liu Z, Wong WL.

J Pharmacol Sci. 2018 Sep;138(1):83-85. doi: 10.1016/j.jphs.2018.09.001. Epub 2018 Sep 10.

10.

Antibacterial activity of 3-methylbenzo[d]thiazol-methylquinolinium derivatives and study of their action mechanism.

Sun N, Du RL, Zheng YY, Guo Q, Cai SY, Liu ZH, Fang ZY, Yuan WC, Liu T, Li XM, Lu YJ, Wong KY.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):879-889. doi: 10.1080/14756366.2018.1465055.

11.

A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.

Kaul M, Parhi AK, Zhang Y, LaVoie EJ, Tuske S, Arnold E, Kerrigan JE, Pilch DS.

J Med Chem. 2012 Nov 26;55(22):10160-76. doi: 10.1021/jm3012728. Epub 2012 Oct 26.

12.

Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity.

Sun N, Chan FY, Lu YJ, Neves MA, Lui HK, Wang Y, Chow KY, Chan KF, Yan SC, Leung YC, Abagyan R, Chan TH, Wong KY.

PLoS One. 2014 May 13;9(5):e97514. doi: 10.1371/journal.pone.0097514. eCollection 2014.

13.

Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action.

Cai S, Yuan W, Li Y, Huang X, Guo Q, Tang Z, Fang Z, Lin H, Wong WL, Wong KY, Lu YJ, Sun N.

Bioorg Med Chem. 2019 Apr 1;27(7):1274-1282. doi: 10.1016/j.bmc.2019.02.024. Epub 2019 Feb 14.

PMID:
30792100
14.

Target Based Virtual Screening of New Leads Inhibitor against Bacterial Cell Division Protein FtsZ for the Discovery of Antibacterial Agents.

Mishra RC, Kumari R, Yadav S, Yadav JP.

Med Chem. 2019 Feb 6. doi: 10.2174/1573406415666190206233448. [Epub ahead of print]

PMID:
30727908
15.

Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action.

Artola M, Ruiz-Avila LB, Vergoñós A, Huecas S, Araujo-Bazán L, Martín-Fontecha M, Vázquez-Villa H, Turrado C, Ramírez-Aportela E, Hoegl A, Nodwell M, Barasoain I, Chacón P, Sieber SA, Andreu JM, López-Rodríguez ML.

ACS Chem Biol. 2015 Mar 20;10(3):834-43. doi: 10.1021/cb500974d. Epub 2014 Dec 30.

PMID:
25486266
16.

Antibacterial evaluation and mode of action study of BIMQ, a novel bacterial cell division inhibitor.

Sun N, Li M, Cai S, Li Y, Chen C, Zheng Y, Li X, Fang Z, Lv H, Lu YJ.

Biochem Biophys Res Commun. 2019 Jul 5;514(4):1224-1230. doi: 10.1016/j.bbrc.2019.05.086. Epub 2019 May 17.

PMID:
31109649
17.

FtsZ inhibitors as a new genera of antibacterial agents.

Tripathy S, Sahu SK.

Bioorg Chem. 2019 Oct;91:103169. doi: 10.1016/j.bioorg.2019.103169. Epub 2019 Jul 30. Review.

PMID:
31398602
18.

Antimicrobial activity of a quinuclidine-based FtsZ inhibitor and its synergistic potential with β-lactam antibiotics.

Chan FY, Sun N, Leung YC, Wong KY.

J Antibiot (Tokyo). 2015 Apr;68(4):253-8. doi: 10.1038/ja.2014.140. Epub 2014 Oct 8.

PMID:
25293977
19.

Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

Ruiz-Avila LB, Huecas S, Artola M, Vergoñós A, Ramírez-Aportela E, Cercenado E, Barasoain I, Vázquez-Villa H, Martín-Fontecha M, Chacón P, López-Rodríguez ML, Andreu JM.

ACS Chem Biol. 2013 Sep 20;8(9):2072-83. doi: 10.1021/cb400208z. Epub 2013 Jul 31.

PMID:
23855511
20.

Doxorubicin inhibits E. coli division by interacting at a novel site in FtsZ.

Panda P, Taviti AC, Satpati S, Kar MM, Dixit A, Beuria TK.

Biochem J. 2015 Nov 1;471(3):335-46. doi: 10.1042/BJ20150467. Epub 2015 Aug 18.

PMID:
26285656

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