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Items: 1 to 20 of 101

1.

Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity.

Chakraborty P, Vaena SG, Thyagarajan K, Chatterjee S, Al-Khami A, Selvam SP, Nguyen H, Kang I, Wyatt MW, Baliga U, Hedley Z, Ngang RN, Guo B, Beeson GC, Husain S, Paulos CM, Beeson CC, Zilliox MJ, Hill EG, Mehrotra M, Yu XZ, Ogretmen B, Mehrotra S.

Cell Rep. 2019 Aug 13;28(7):1879-1893.e7. doi: 10.1016/j.celrep.2019.07.044.

2.
3.

Sphk1/S1P/S1PR1 Signaling is Involved in the Development of Autoimmune Thyroiditis in Patients and NOD.H-2h4 Mice.

Han C, He X, Xia X, Guo J, Liu A, Liu X, Wang X, Li C, Peng S, Zhao W, Zhou M, Shi X, Li Y, Li Y, Shan Z, Teng W.

Thyroid. 2019 May;29(5):700-713. doi: 10.1089/thy.2018.0065.

PMID:
30963819
4.

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis.

Parham KA, Zebol JR, Tooley KL, Sun WY, Moldenhauer LM, Cockshell MP, Gliddon BL, Moretti PA, Tigyi G, Pitson SM, Bonder CS.

FASEB J. 2015 Sep;29(9):3638-53. doi: 10.1096/fj.14-261289. Epub 2015 May 18.

5.

Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.

Wang X, Zhang DM, Gu TT, Ding XQ, Fan CY, Zhu Q, Shi YW, Hong Y, Kong LD.

Biochem Pharmacol. 2013 Dec 15;86(12):1791-804. doi: 10.1016/j.bcp.2013.10.005. Epub 2013 Oct 14.

PMID:
24134913
6.

Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium.

Fu P, Ebenezer DL, Berdyshev EV, Bronova IA, Shaaya M, Harijith A, Natarajan V.

J Biol Chem. 2016 Dec 30;291(53):27187-27203. doi: 10.1074/jbc.M116.758946. Epub 2016 Nov 18.

7.

Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest.

Gorshkova IA, Wang H, Orbelyan GA, Goya J, Natarajan V, Beiser DG, Vanden Hoek TL, Berdyshev EV.

Life Sci. 2013 Sep 17;93(9-11):359-66. doi: 10.1016/j.lfs.2013.07.017. Epub 2013 Jul 24.

PMID:
23892195
8.

AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose.

Huang K, Huang J, Chen C, Hao J, Wang S, Huang J, Liu P, Huang H.

Cell Signal. 2014 Mar;26(3):629-38. doi: 10.1016/j.cellsig.2013.12.002. Epub 2013 Dec 14.

PMID:
24342046
9.

Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia.

Natarajan V, Ha AW, Dong Y, Reddy NM, Ebenezer DL, Kanteti P, Reddy SP, Usha Raj J, Lei Z, Maienschein-Cline M, Arbieva Z, Harijith A.

BMC Genomics. 2017 Aug 29;18(1):664. doi: 10.1186/s12864-017-4048-0.

10.

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.

Chen J, Wang W, Qi Y, Kaczorowski D, McCaughan GW, Gamble JR, Don AS, Gao X, Vadas MA, Xia P.

Biochim Biophys Acta. 2016 Feb;1861(2):138-147. doi: 10.1016/j.bbalip.2015.11.006. Epub 2015 Nov 23.

PMID:
26615875
11.

Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis.

Dai L, Liu Y, Xie L, Wu X, Qiu L, Di W.

Oncotarget. 2017 Aug 24;8(43):74947-74961. doi: 10.18632/oncotarget.20471. eCollection 2017 Sep 26.

12.

Sphingosine kinase 1 in viral infections.

Carr JM, Mahalingam S, Bonder CS, Pitson SM.

Rev Med Virol. 2013 Mar;23(2):73-84. doi: 10.1002/rmv.1718. Epub 2012 May 28. Review.

PMID:
22639116
13.

Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells.

Böhm A, Flößer A, Ermler S, Fender AC, Lüth A, Kleuser B, Schrör K, Rauch BH.

Cardiovasc Res. 2013 Aug 1;99(3):505-13. doi: 10.1093/cvr/cvt112. Epub 2013 May 7.

PMID:
23658376
15.

Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions.

Fischer I, Alliod C, Martinier N, Newcombe J, Brana C, Pouly S.

PLoS One. 2011;6(8):e23905. doi: 10.1371/journal.pone.0023905. Epub 2011 Aug 24.

16.

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

Schnute ME, McReynolds MD, Kasten T, Yates M, Jerome G, Rains JW, Hall T, Chrencik J, Kraus M, Cronin CN, Saabye M, Highkin MK, Broadus R, Ogawa S, Cukyne K, Zawadzke LE, Peterkin V, Iyanar K, Scholten JA, Wendling J, Fujiwara H, Nemirovskiy O, Wittwer AJ, Nagiec MM.

Biochem J. 2012 May 15;444(1):79-88. doi: 10.1042/BJ20111929.

PMID:
22397330
17.

Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

Allende ML, Sasaki T, Kawai H, Olivera A, Mi Y, van Echten-Deckert G, Hajdu R, Rosenbach M, Keohane CA, Mandala S, Spiegel S, Proia RL.

J Biol Chem. 2004 Dec 10;279(50):52487-92. Epub 2004 Sep 30.

18.

Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells.

Jiang ZJ, Delaney TL, Zanin MP, Haberberger RV, Pitson SM, Huang J, Alford S, Cologna SM, Keating DJ, Gong LW.

J Neurochem. 2019 Jun;149(6):729-746. doi: 10.1111/jnc.14703. Epub 2019 May 8.

PMID:
30963576
19.

Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration.

Maceyka M, Alvarez SE, Milstien S, Spiegel S.

Mol Cell Biol. 2008 Sep;28(18):5687-97. doi: 10.1128/MCB.00465-08. Epub 2008 Jul 21.

20.

SPHK1 promotes metastasis of thyroid carcinoma through activation of the S1P/S1PR3/Notch signaling pathway.

Zhao Z, Ma J, Hu B, Zhang Y, Wang S.

Exp Ther Med. 2018 Jun;15(6):5007-5016. doi: 10.3892/etm.2018.6054. Epub 2018 Apr 12.

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