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Items: 1 to 20 of 89

1.

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.

Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT 4th, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Briseño CG, Grajales-Reyes GE, Wöhner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM.

Nat Immunol. 2019 Sep;20(9):1161-1173. doi: 10.1038/s41590-019-0450-x. Epub 2019 Aug 12.

PMID:
31406378
2.

An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.

Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM.

Nat Immunol. 2019 Sep;20(9):1174-1185. doi: 10.1038/s41590-019-0449-3. Epub 2019 Aug 12.

PMID:
31406377
3.

Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.

Kurotaki D, Kawase W, Sasaki H, Nakabayashi J, Nishiyama A, Morse HC 3rd, Ozato K, Suzuki Y, Tamura T.

Blood. 2019 Apr 25;133(17):1803-1813. doi: 10.1182/blood-2018-06-857789. Epub 2019 Feb 22.

PMID:
30796024
4.

Batf3-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation.

Theisen DJ, Ferris ST, Briseño CG, Kretzer N, Iwata A, Murphy KM, Murphy TL.

Cancer Immunol Res. 2019 Jan;7(1):29-39. doi: 10.1158/2326-6066.CIR-18-0138. Epub 2018 Nov 27.

PMID:
30482745
5.

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.

Sontag S, Förster M, Qin J, Wanek P, Mitzka S, Schüler HM, Koschmieder S, Rose-John S, Seré K, Zenke M.

Stem Cells. 2017 Apr;35(4):898-908. doi: 10.1002/stem.2565. Epub 2017 Feb 1.

6.

Allograft Inflammatory Factor-1 Governs Hematopoietic Stem Cell Differentiation Into cDC1 and Monocyte-Derived Dendritic Cells Through IRF8 and RelB in vitro.

Elizondo DM, Brandy NZD, da Silva RLL, Haddock NL, Kacsinta AD, de Moura TR, Lipscomb MW.

Front Immunol. 2019 Feb 8;10:173. doi: 10.3389/fimmu.2019.00173. eCollection 2019.

7.

IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively.

Sichien D, Scott CL, Martens L, Vanderkerken M, Van Gassen S, Plantinga M, Joeris T, De Prijck S, Vanhoutte L, Vanheerswynghels M, Van Isterdael G, Toussaint W, Madeira FB, Vergote K, Agace WW, Clausen BE, Hammad H, Dalod M, Saeys Y, Lambrecht BN, Guilliams M.

Immunity. 2016 Sep 20;45(3):626-640. doi: 10.1016/j.immuni.2016.08.013. Epub 2016 Sep 13.

8.

Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.

Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kawase W, Kaneko N, Ochiai K, Igarashi K, Ozato K, Suzuki Y, Tamura T.

Cell Rep. 2018 Mar 6;22(10):2628-2641. doi: 10.1016/j.celrep.2018.02.048.

9.

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.

Grajales-Reyes GE, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, Kretzer NM, Briseño CG, Durai V, Bagadia P, Haldar M, Schönheit J, Rosenbauer F, Murphy TL, Murphy KM.

Nat Immunol. 2015 Jul;16(7):708-17. doi: 10.1038/ni.3197. Epub 2015 Jun 8.

10.

IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells.

Bajaña S, Turner S, Paul J, Ainsua-Enrich E, Kovats S.

J Immunol. 2016 Feb 15;196(4):1666-77. doi: 10.4049/jimmunol.1501870. Epub 2016 Jan 8.

11.

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.

Kirkling ME, Cytlak U, Lau CM, Lewis KL, Resteu A, Khodadadi-Jamayran A, Siebel CW, Salmon H, Merad M, Tsirigos A, Collin M, Bigley V, Reizis B.

Cell Rep. 2018 Jun 19;23(12):3658-3672.e6. doi: 10.1016/j.celrep.2018.05.068.

12.

PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment.

Schönheit J, Kuhl C, Gebhardt ML, Klett FF, Riemke P, Scheller M, Huang G, Naumann R, Leutz A, Stocking C, Priller J, Andrade-Navarro MA, Rosenbauer F.

Cell Rep. 2013 May 30;3(5):1617-28. doi: 10.1016/j.celrep.2013.04.007. Epub 2013 Apr 25.

13.

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.

Schlitzer A, Sivakamasundari V, Chen J, Sumatoh HR, Schreuder J, Lum J, Malleret B, Zhang S, Larbi A, Zolezzi F, Renia L, Poidinger M, Naik S, Newell EW, Robson P, Ginhoux F.

Nat Immunol. 2015 Jul;16(7):718-28. doi: 10.1038/ni.3200. Epub 2015 Jun 8.

PMID:
26054720
14.

IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.

Yáñez A, Ng MY, Hassanzadeh-Kiabi N, Goodridge HS.

Blood. 2015 Feb 26;125(9):1452-9. doi: 10.1182/blood-2014-09-600833. Epub 2015 Jan 16.

PMID:
25597637
15.

IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils.

Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, Nakazawa M, Ozato K, Tamura T.

Nat Commun. 2014 Sep 19;5:4978. doi: 10.1038/ncomms5978.

PMID:
25236377
16.

Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.

Kurotaki D, Osato N, Nishiyama A, Yamamoto M, Ban T, Sato H, Nakabayashi J, Umehara M, Miyake N, Matsumoto N, Nakazawa M, Ozato K, Tamura T.

Blood. 2013 Mar 7;121(10):1839-49. doi: 10.1182/blood-2012-06-437863. Epub 2013 Jan 14.

17.

A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States.

Bornstein C, Winter D, Barnett-Itzhaki Z, David E, Kadri S, Garber M, Amit I.

Mol Cell. 2014 Dec 18;56(6):749-62. doi: 10.1016/j.molcel.2014.10.014. Epub 2014 Nov 20.

18.

Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.

Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon LI, Yuan GC, Orkin SH, Xu J.

Dev Cell. 2016 Jan 11;36(1):9-23. doi: 10.1016/j.devcel.2015.12.014.

19.

IRF8 regulates B-cell lineage specification, commitment, and differentiation.

Wang H, Lee CH, Qi C, Tailor P, Feng J, Abbasi S, Atsumi T, Morse HC 3rd.

Blood. 2008 Nov 15;112(10):4028-38. doi: 10.1182/blood-2008-01-129049. Epub 2008 Sep 17.

20.

Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.

Wu X, Briseño CG, Grajales-Reyes GE, Haldar M, Iwata A, Kretzer NM, Kc W, Tussiwand R, Higashi Y, Murphy TL, Murphy KM.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14775-14780. doi: 10.1073/pnas.1611408114. Epub 2016 Dec 5.

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