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Effect of caloric restriction and rapamycin on ovarian aging in mice.

Garcia DN, Saccon TD, Pradiee J, Rincón JAA, Andrade KRS, Rovani MT, Mondadori RG, Cruz LAX, Barros CC, Masternak MM, Bartke A, Mason JB, Schneider A.

Geroscience. 2019 Jul 29. doi: 10.1007/s11357-019-00087-x. [Epub ahead of print]


SIRT1 knock-in mice preserve ovarian reserve resembling caloric restriction.

Long GY, Yang JY, Xu JJ, Ni YH, Zhou XL, Ma JY, Fu YC, Luo LL.

Gene. 2019 Feb 20;686:194-202. doi: 10.1016/j.gene.2018.10.040. Epub 2018 Oct 17.


Obesity accelerates ovarian follicle development and follicle loss in rats.

Wang N, Luo LL, Xu JJ, Xu MY, Zhang XM, Zhou XL, Liu WJ, Fu YC.

Metabolism. 2014 Jan;63(1):94-103. doi: 10.1016/j.metabol.2013.09.001. Epub 2013 Oct 14.


[Protective effects of caloric restriction on ovarian function].

Shi LY, Luo AY, Tian Y, Lai ZW, Zhang JJ, Wang SX.

Zhonghua Fu Chan Ke Za Zhi. 2013 Oct;48(10):745-9. Chinese.


Are sirtuins markers of ovarian aging?

Zhang J, Fang L, Lu Z, Xiong J, Wu M, Shi L, Luo A, Wang S.

Gene. 2016 Jan 10;575(2 Pt 3):680-6. doi: 10.1016/j.gene.2015.09.043. Epub 2015 Sep 25.


SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling.

Zhou XL, Xu JJ, Ni YH, Chen XC, Zhang HX, Zhang XM, Liu WJ, Luo LL, Fu YC.

J Ovarian Res. 2014 Oct 21;7:97. doi: 10.1186/s13048-014-0097-z.


Calorie restriction increases primordial follicle reserve in mature female chemotherapy-treated rats.

Xiang Y, Xu J, Li L, Lin X, Chen X, Zhang X, Fu Y, Luo L.

Gene. 2012 Feb 1;493(1):77-82. doi: 10.1016/j.gene.2011.11.019. Epub 2011 Nov 28.


Caloric restriction promotes the reserve of follicle pool in adult female rats by inhibiting the activation of mammalian target of rapamycin signaling.

Li L, Fu YC, Xu JJ, Lin XH, Chen XC, Zhang XM, Luo LL.

Reprod Sci. 2015 Jan;22(1):60-7. doi: 10.1177/1933719114542016. Epub 2014 Jul 6.


Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice.

Liu WJ, Zhang XM, Wang N, Zhou XL, Fu YC, Luo LL.

Eur J Med Res. 2015 Mar 12;20:22. doi: 10.1186/s40001-015-0114-8.


Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo.

Zhou L, Xie Y, Li S, Liang Y, Qiu Q, Lin H, Zhang Q.

J Ovarian Res. 2017 Aug 16;10(1):56. doi: 10.1186/s13048-017-0350-3.


Primordial follicle activation in the ovary of Ames dwarf mice.

Schneider A, Zhi X, Moreira F, Lucia T Jr, Mondadori RG, Masternak MM.

J Ovarian Res. 2014 Dec 29;7:120. doi: 10.1186/s13048-014-0120-4.


The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats.

Luo LL, Chen XC, Fu YC, Xu JJ, Li L, Lin XH, Xiang YF, Zhang XM.

Aging Clin Exp Res. 2012 Apr;24(2):125-33. doi: 10.3275/7660. Epub 2011 Apr 14.


New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.

Sun X, Su Y, He Y, Zhang J, Liu W, Zhang H, Hou Z, Liu J, Li J.

Cell Cycle. 2015;14(5):721-31. doi: 10.1080/15384101.2014.995496.


Effects of plant polyphenols on ovarian follicular reserve in aging rats.

Chen ZG, Luo LL, Xu JJ, Zhuang XL, Kong XX, Fu YC.

Biochem Cell Biol. 2010 Aug;88(4):737-45. doi: 10.1139/O10-012.


Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression.

Zhang XM, Li L, Xu JJ, Wang N, Liu WJ, Lin XH, Fu YC, Luo LL.

Gene. 2013 Jul 1;523(1):82-7. doi: 10.1016/j.gene.2013.03.039. Epub 2013 Apr 6.


Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer.

Lashinger LM, Malone LM, Brown GW, Daniels EA, Goldberg JA, Otto G, Fischer SM, Hursting SD.

Cancer Prev Res (Phila). 2011 Jul;4(7):1041-51. doi: 10.1158/1940-6207.CAPR-11-0023. Epub 2011 May 18.


Restricting the induction of NGF in ovarian stroma engenders selective follicular activation through the mTOR signaling pathway.

He Y, Peng X, Wu T, Yang W, Liu W, Zhang J, Su Y, Kong F, Dou X, Li J.

Cell Death Dis. 2017 May 25;8(5):e2817. doi: 10.1038/cddis.2017.168.


mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy.

Goldman KN, Chenette D, Arju R, Duncan FE, Keefe DL, Grifo JA, Schneider RJ.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3186-3191. doi: 10.1073/pnas.1617233114. Epub 2017 Mar 7.


Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure.

Pascuali N, Scotti L, Di Pietro M, Oubiña G, Bas D, May M, Gómez Muñoz A, Cuasnicú PS, Cohen DJ, Tesone M, Abramovich D, Parborell F.

Hum Reprod. 2018 May 1;33(5):844-859. doi: 10.1093/humrep/dey045.


Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.

Dai DF, Karunadharma PP, Chiao YA, Basisty N, Crispin D, Hsieh EJ, Chen T, Gu H, Djukovic D, Raftery D, Beyer RP, MacCoss MJ, Rabinovitch PS.

Aging Cell. 2014 Jun;13(3):529-39. doi: 10.1111/acel.12203. Epub 2014 Feb 25.

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