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N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells.

Wang K, Chen B, Yin T, Zhan Y, Lu Y, Zhang Y, Chen J, Wu W, Zhou S, Mao W, Tan Y, Du B, Liu X, Ho HI, Xiao J.

Int J Mol Sci. 2019 Jul 11;20(14). pii: E3415. doi: 10.3390/ijms20143415.


Inhibition of autophagic flux by ROS promotes apoptosis during DTT-induced ER/oxidative stress in HeLa cells.

Xiang XY, Yang XC, Su J, Kang JS, Wu Y, Xue YN, Dong YT, Sun LK.

Oncol Rep. 2016 Jun;35(6):3471-9. doi: 10.3892/or.2016.4725. Epub 2016 Apr 1.


Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Niu NK, Wang ZL, Pan ST, Ding HQ, Au GH, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF.

Drug Des Devel Ther. 2015 Mar 12;9:1555-84. doi: 10.2147/DDDT.S74197. eCollection 2015.


Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK.

Liu J, Chang F, Li F, Fu H, Wang J, Zhang S, Zhao J, Yin D.

Biochem Biophys Res Commun. 2015 Jul 31;463(3):262-7. doi: 10.1016/j.bbrc.2015.05.042. Epub 2015 May 19.


Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells.

Wang P, Gao C, Wang W, Yao LP, Zhang J, Zhang SD, Li J, Fang SH, Fu YJ.

Food Chem Toxicol. 2018 Jun;116(Pt B):40-50. doi: 10.1016/j.fct.2018.04.004. Epub 2018 Apr 6.


Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer.

Kao SJ, Lee WJ, Chang JH, Chow JM, Chung CL, Hung WY, Chien MH.

Environ Toxicol. 2017 Apr;32(4):1426-1438. doi: 10.1002/tox.22336. Epub 2016 Aug 19.


Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway.

Park GB, Kim YS, Lee HK, Song H, Cho DH, Lee WJ, Hur DY.

J Immunol. 2010 Dec 15;185(12):7274-84. doi: 10.4049/jimmunol.1001547. Epub 2010 Nov 15.


A novel synthetic analog of Militarin, MA-1 induces mitochondrial dependent apoptosis by ROS generation in human lung cancer cells.

Yoon DH, Lim MH, Lee YR, Sung GH, Lee TH, Jeon BH, Cho JY, Song WO, Park H, Choi S, Kim TW.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):659-71. doi: 10.1016/j.taap.2013.10.015. Epub 2013 Oct 22.


Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK.

Wang J, Li J, Cao N, Li Z, Han J, Li L.

Onco Targets Ther. 2018 Nov 2;11:7777-7786. doi: 10.2147/OTT.S159095. eCollection 2018.


Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways.

Lu TH, Tseng TJ, Su CC, Tang FC, Yen CC, Liu YY, Yang CY, Wu CC, Chen KL, Hung DZ, Chen YW.

Toxicol Lett. 2014 Jan 3;224(1):130-40. doi: 10.1016/j.toxlet.2013.10.013. Epub 2013 Oct 21.


Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.

Duan F, Yu Y, Guan R, Xu Z, Liang H, Hong L.

PLoS One. 2016 Aug 29;11(8):e0161886. doi: 10.1371/journal.pone.0161886. eCollection 2016.


Albumin prevents reactive oxygen species-induced mitochondrial damage, autophagy, and apoptosis during serum starvation.

Liu SY, Chen CL, Yang TT, Huang WC, Hsieh CY, Shen WJ, Tsai TT, Shieh CC, Lin CF.

Apoptosis. 2012 Nov;17(11):1156-69. doi: 10.1007/s10495-012-0758-6.


Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation.

Chang KC, Hsu CC, Liu SH, Su CC, Yen CC, Lee MJ, Chen KL, Ho TJ, Hung DZ, Wu CC, Lu TH, Su YC, Chen YW, Huang CF.

PLoS One. 2013;8(2):e54374. doi: 10.1371/journal.pone.0054374. Epub 2013 Feb 6.


Rasfonin promotes autophagy and apoptosis via upregulation of reactive oxygen species (ROS)/JNK pathway.

Wang W, Sun H, Che Y, Jiang X.

Mycology. 2016 Apr 6;7(2):64-73. doi: 10.1080/21501203.2016.1170073. eCollection 2016.


SL4, a chalcone-based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway.

Wang LH, Li HH, Li M, Wang S, Jiang XR, Li Y, Ping GF, Cao Q, Liu X, Fang WH, Chen GL, Yang JY, Wu CF.

Cell Prolif. 2015 Dec;48(6):718-28. doi: 10.1111/cpr.12226. Epub 2015 Oct 26.


Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway.

Ma K, Zhang C, Huang MY, Li WY, Hu GQ.

Oncol Rep. 2016 Jul;36(1):90-8. doi: 10.3892/or.2016.4782. Epub 2016 Apr 28.


Erlotinib induces the human non-small-cell lung cancer cells apoptosis via activating ROS-dependent JNK pathways.

Shan F, Shao Z, Jiang S, Cheng Z.

Cancer Med. 2016 Nov;5(11):3166-3175. doi: 10.1002/cam4.881. Epub 2016 Oct 10.

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