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Disc degeneration induces a mechano-sensitization of disc afferent nerve fibers that associates with low back pain.

Park EH, Moon SW, Suh HR, Hochman S, Lee MG, Kim YI, Jang IT, Han HC.

Osteoarthritis Cartilage. 2019 Nov;27(11):1608-1617. doi: 10.1016/j.joca.2019.07.010. Epub 2019 Jul 19.


ISSLS prize winner: disc dynamic compression in rats produces long-lasting increases in inflammatory mediators in discs and induces long-lasting nerve injury and regeneration of the afferent fibers innervating discs: a pathomechanism for chronic discogenic low back pain.

Miyagi M, Ishikawa T, Kamoda H, Suzuki M, Murakami K, Shibayama M, Orita S, Eguchi Y, Arai G, Sakuma Y, Kubota G, Oikawa Y, Ozawa T, Aoki Y, Toyone T, Takahashi K, Inoue G, Kawakami M, Ohtori S.

Spine (Phila Pa 1976). 2012 Oct 1;37(21):1810-8.


Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation: Laboratory investigation.

Kao TH, Peng YJ, Tsou HK, Salter DM, Lee HS.

J Neurosurg Spine. 2014 Oct;21(4):653-61. doi: 10.3171/2014.6.SPINE13756. Epub 2014 Jul 25.


Safety of intradiscal delivery of triamcinolone acetonide by a poly(esteramide) microsphere platform in a large animal model of intervertebral disc degeneration.

Rudnik-Jansen I, Tellegen A, Beukers M, ├ľner F, Woike N, Mihov G, Thies J, Meij B, Tryfonidou M, Creemers L.

Spine J. 2019 May;19(5):905-919. doi: 10.1016/j.spinee.2018.10.014. Epub 2018 Oct 26.


ISSLS Prize winner: Increased innervation and sensory nervous system plasticity in a mouse model of low back pain due to intervertebral disc degeneration.

Miyagi M, Millecamps M, Danco AT, Ohtori S, Takahashi K, Stone LS.

Spine (Phila Pa 1976). 2014 Aug 1;39(17):1345-54. doi: 10.1097/BRS.0000000000000334.


Inhibiting tumor necrosis factor-alpha at time of induced intervertebral disc injury limits long-term pain and degeneration in a rat model.

Evashwick-Rogler TW, Lai A, Watanabe H, Salandra JM, Winkelstein BA, Cho SK, Hecht AC, Iatridis JC.

JOR Spine. 2018 Jun;1(2). pii: e1014. doi: 10.1002/jsp2.1014. Epub 2018 May 21.


Lumbar intervertebral disc degeneration associated with axial and radiating low back pain in ageing SPARC-null mice.

Millecamps M, Tajerian M, Naso L, Sage EH, Stone LS.

Pain. 2012 Jun;153(6):1167-79. doi: 10.1016/j.pain.2012.01.027. Epub 2012 Mar 11.


Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.

Lai A, Moon A, Purmessur D, Skovrlj B, Laudier DM, Winkelstein BA, Cho SK, Hecht AC, Iatridis JC.

Spine J. 2016 Mar;16(3):420-31. doi: 10.1016/j.spinee.2015.11.019. Epub 2015 Dec 2.


Efficacy of anti-nerve growth factor therapy for discogenic neck pain in rats.

Sainoh T, Sakuma Y, Miyagi M, Orita S, Yamauchi K, Inoue G, Kamoda H, Ishikawa T, Suzuki M, Kubota G, Oikawa Y, Inage K, Sato J, Nakamura J, Aoki Y, Takaso M, Toyone T, Takahashi K, Ohtori S.

Spine (Phila Pa 1976). 2014 Jun 1;39(13):E757-62. doi: 10.1097/BRS.0000000000000340.


Pathomechanisms of discogenic low back pain in humans and animal models.

Ohtori S, Inoue G, Miyagi M, Takahashi K.

Spine J. 2015 Jun 1;15(6):1347-55. doi: 10.1016/j.spinee.2013.07.490. Epub 2014 Mar 20. Review.


Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc.

Purmessur D, Freemont AJ, Hoyland JA.

Arthritis Res Ther. 2008;10(4):R99. doi: 10.1186/ar2487. Epub 2008 Aug 27.


Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incision.

Pogatzki EM, Gebhart GF, Brennan TJ.

J Neurophysiol. 2002 Feb;87(2):721-31.


Establishment and Characterization of a Novel Rat Model of Mechanical Low Back Pain Using Behavioral, Pharmacologic and Histologic Methods.

Muralidharan A, Park TSW, Mackie JT, Gimenez LGS, Kuo A, Nicholson JR, Corradini L, Smith MT.

Front Pharmacol. 2017 Jul 27;8:493. doi: 10.3389/fphar.2017.00493. eCollection 2017.


Anti-inflammatory Chitosan/Poly-╬│-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc.

Teixeira GQ, Leite Pereira C, Castro F, Ferreira JR, Gomez-Lazaro M, Aguiar P, Barbosa MA, Neidlinger-Wilke C, Goncalves RM.

Acta Biomater. 2016 Sep 15;42:168-179. doi: 10.1016/j.actbio.2016.06.013. Epub 2016 Jun 15.


Nerve growth factor expression and innervation of the painful intervertebral disc.

Freemont AJ, Watkins A, Le Maitre C, Baird P, Jeziorska M, Knight MT, Ross ER, O'Brien JP, Hoyland JA.

J Pathol. 2002 Jul;197(3):286-92.


Exposure of the nucleus pulposus to the outside of the anulus fibrosus induces nerve injury and regeneration of the afferent fibers innervating the lumbar intervertebral discs in rats.

Inoue G, Ohtori S, Aoki Y, Ozawa T, Doya H, Saito T, Ito T, Akazawa T, Moriya H, Takahashi K.

Spine (Phila Pa 1976). 2006 Jun 1;31(13):1433-8.


Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats.

Wegert S, Ossipov MH, Nichols ML, Bian D, Vanderah TW, Malan TP Jr, Porreca F.

Pain. 1997 May;71(1):57-64.


3D finite element analysis of nutrient distributions and cell viability in the intervertebral disc: effects of deformation and degeneration.

Jackson AR, Huang CY, Brown MD, Gu WY.

J Biomech Eng. 2011 Sep;133(9):091006. doi: 10.1115/1.4004944.


Lumbar posterolateral fusion inhibits sensory nerve ingrowth into punctured lumbar intervertebral discs and upregulation of CGRP immunoreactive DRG neuron innervating punctured discs in rats.

Koshi T, Ohtori S, Inoue G, Ito T, Yamashita M, Yamauchi K, Suzuki M, Aoki Y, Takahashi K.

Eur Spine J. 2010 Apr;19(4):593-600. doi: 10.1007/s00586-009-1237-9. Epub 2009 Dec 12.


Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc.

Richardson SM, Doyle P, Minogue BM, Gnanalingham K, Hoyland JA.

Arthritis Res Ther. 2009;11(4):R126. doi: 10.1186/ar2793. Epub 2009 Aug 20.

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