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Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice.

Nakajima R, Takao K, Hattori S, Shoji H, Komiyama NH, Grant SGN, Miyakawa T.

Neuropsychopharmacol Rep. 2019 Sep;39(3):223-237. doi: 10.1002/npr2.12073. Epub 2019 Jul 19.


Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory.

Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, Tanaka T.

PLoS One. 2018 Apr 27;13(4):e0196587. doi: 10.1371/journal.pone.0196587. eCollection 2018.


ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response.

Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S, Miyakawa T.

BMC Res Notes. 2013 May 21;6:203. doi: 10.1186/1756-0500-6-203.


Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age.

Shoji H, Takao K, Hattori S, Miyakawa T.

Mol Brain. 2016 Jan 28;9:11. doi: 10.1186/s13041-016-0191-9.


Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse.

Matsuda I, Shoji H, Yamasaki N, Miyakawa T, Aiba A.

Mol Brain. 2016 Feb 9;9:15. doi: 10.1186/s13041-016-0196-4.


Age-related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program.

Shoji H, Miyakawa T.

Neuropsychopharmacol Rep. 2019 Jun;39(2):100-118. doi: 10.1002/npr2.12052. Epub 2019 Feb 27.


SYNGAP1-Related Intellectual Disability.

Holder JL Jr, Hamdan FF, Michaud JL.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2019 Feb 21.


Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.

Maeta K, Hattori S, Ikutomo J, Edamatsu H, Bilasy SE, Miyakawa T, Kataoka T.

Mol Brain. 2018 May 10;11(1):27. doi: 10.1186/s13041-018-0370-y.


SYNGAP1: Mind the Gap.

Jeyabalan N, Clement JP.

Front Cell Neurosci. 2016 Feb 15;10:32. doi: 10.3389/fncel.2016.00032. eCollection 2016. Review.


Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout.

Muhia M, Willadt S, Yee BK, Feldon J, Paterna JC, Schwendener S, Vogt K, Kennedy MB, Knuesel I.

Learn Mem. 2012 Jun 14;19(7):268-81. doi: 10.1101/lm.026351.112.


Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice.

Shoji H, Toyama K, Takamiya Y, Wakana S, Gondo Y, Miyakawa T.

BMC Res Notes. 2012 Feb 20;5:108. doi: 10.1186/1756-0500-5-108.


Behavioral Phenotyping of an Improved Mouse Model of Phelan-McDermid Syndrome with a Complete Deletion of the Shank3 Gene.

Drapeau E, Riad M, Kajiwara Y, Buxbaum JD.

eNeuro. 2018 Oct 5;5(3). pii: ENEURO.0046-18.2018. doi: 10.1523/ENEURO.0046-18.2018. eCollection 2018 May-Jun.


De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability.

Parker MJ, Fryer AE, Shears DJ, Lachlan KL, McKee SA, Magee AC, Mohammed S, Vasudevan PC, Park SM, Benoit V, Lederer D, Maystadt I, Study D, FitzPatrick DR.

Am J Med Genet A. 2015 Oct;167A(10):2231-7. doi: 10.1002/ajmg.a.37189. Epub 2015 Jun 15.


Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.

Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ.

J Neurosci. 2015 Nov 11;35(45):15073-81. doi: 10.1523/JNEUROSCI.1087-15.2015.


Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes.

Fujioka R, Nii T, Iwaki A, Shibata A, Ito I, Kitaichi K, Nomura M, Hattori S, Takao K, Miyakawa T, Fukumaki Y.

Mol Brain. 2014 Apr 23;7:31. doi: 10.1186/1756-6606-7-31.


Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly.

Aceti M, Creson TK, Vaissiere T, Rojas C, Huang WC, Wang YX, Petralia RS, Page DT, Miller CA, Rumbaugh G.

Biol Psychiatry. 2015 May 1;77(9):805-15. doi: 10.1016/j.biopsych.2014.08.001. Epub 2014 Aug 13.


Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.

Wurzman R, Forcelli PA, Griffey CJ, Kromer LF.

Behav Brain Res. 2015 Feb 1;278:115-28. doi: 10.1016/j.bbr.2014.09.012. Epub 2014 Oct 2.


Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity.

Paul A, Nawalpuri B, Shah D, Sateesh S, Muddashetty RS, Clement JP.

Front Mol Neurosci. 2019 May 9;12:97. doi: 10.3389/fnmol.2019.00097. eCollection 2019.


Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.

Kozol RA, Cukier HN, Zou B, Mayo V, De Rubeis S, Cai G, Griswold AJ, Whitehead PL, Haines JL, Gilbert JR, Cuccaro ML, Martin ER, Baker JD, Buxbaum JD, Pericak-Vance MA, Dallman JE.

Hum Mol Genet. 2015 Jul 15;24(14):4006-23. doi: 10.1093/hmg/ddv138. Epub 2015 Apr 16.


Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion.

Shibata M, Yamasaki N, Miyakawa T, Kalaria RN, Fujita Y, Ohtani R, Ihara M, Takahashi R, Tomimoto H.

Stroke. 2007 Oct;38(10):2826-32. Epub 2007 Aug 30.


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