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A positive feedback between IDO1 metabolite and COL12A1 via MAPK pathway to promote gastric cancer metastasis.

Xiang Z, Li J, Song S, Wang J, Cai W, Hu W, Ji J, Zhu Z, Zang L, Yan R, Yu Y.

J Exp Clin Cancer Res. 2019 Jul 17;38(1):314. doi: 10.1186/s13046-019-1318-5.


COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer.

Jiang X, Wu M, Xu X, Zhang L, Huang Y, Xu Z, He K, Wang H, Wang H, Teng L.

Mol Med Rep. 2019 Aug 1. doi: 10.3892/mmr.2019.10548. [Epub ahead of print]


Co-expression network analysis identified CDH11 in association with progression and prognosis in gastric cancer.

Chen PF, Wang F, Nie JY, Feng JR, Liu J, Zhou R, Wang HL, Zhao Q.

Onco Targets Ther. 2018 Oct 2;11:6425-6436. doi: 10.2147/OTT.S176511. eCollection 2018.


IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice.

Thaker AI, Rao MS, Bishnupuri KS, Kerr TA, Foster L, Marinshaw JM, Newberry RD, Stenson WF, Ciorba MA.

Gastroenterology. 2013 Aug;145(2):416-25.e1-4. doi: 10.1053/j.gastro.2013.05.002. Epub 2013 May 10.


Interferon-γ induces a tryptophan-selective amino acid transporter in human colonic epithelial cells and mouse dendritic cells.

Bhutia YD, Babu E, Ganapathy V.

Biochim Biophys Acta. 2015 Feb;1848(2):453-62. doi: 10.1016/j.bbamem.2014.10.021. Epub 2014 Oct 23.


High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response.

Ziklo N, Huston WM, Taing K, Timms P.

BMC Infect Dis. 2019 Mar 4;19(1):218. doi: 10.1186/s12879-019-3843-4.


Microenvironment Tumor Metabolic Interactions Highlighted by qMSI: Application to the Tryptophan-Kynurenine Pathway in Immuno-Oncology.

Ait-Belkacem R, Bol V, Hamm G, Schramme F, Van Den Eynde B, Poncelet L, Pamelard F, Stauber J, Gomes B.

SLAS Discov. 2017 Dec;22(10):1182-1192. doi: 10.1177/2472555217712659. Epub 2017 May 30.


Novel prognostic biomarkers of gastric cancer based on gene expression microarray: COL12A1, GSTA3, FGA and FGG.

Duan S, Gong B, Wang P, Huang H, Luo L, Liu F.

Mol Med Rep. 2018 Oct;18(4):3727-3736. doi: 10.3892/mmr.2018.9368. Epub 2018 Aug 9.


Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer.

Dewi DL, Mohapatra SR, Blanco Cabañes S, Adam I, Somarribas Patterson LF, Berdel B, Kahloon M, Thürmann L, Loth S, Heilmann K, Weichenhan D, Mücke O, Heiland I, Wimberger P, Kuhlmann JD, Kellner KH, Schott S, Plass C, Platten M, Gerhäuser C, Trump S, Opitz CA.

Oncoimmunology. 2017 Jan 3;6(2):e1274477. doi: 10.1080/2162402X.2016.1274477. eCollection 2017.


Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.

El-Zaatari M, Bass AJ, Bowlby R, Zhang M, Syu LJ, Yang Y, Grasberger H, Shreiner A, Tan B, Bishu S, Leung WK, Todisco A, Kamada N, Cascalho M, Dlugosz AA, Kao JY.

Gastroenterology. 2018 Jan;154(1):140-153.e17. doi: 10.1053/j.gastro.2017.09.002. Epub 2017 Sep 11.


Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.

Moretti S, Menicali E, Nucci N, Voce P, Colella R, Melillo RM, Liotti F, Morelli S, Fallarino F, Macchiarulo A, Santoro M, Avenia N, Puxeddu E.

J Biol Chem. 2017 Feb 3;292(5):1785-1797. doi: 10.1074/jbc.M116.745448. Epub 2016 Dec 19.


The expanding roles of 1-methyl-tryptophan (1-MT): in addition to inhibiting kynurenine production, 1-MT activates the synthesis of melatonin in skin cells.

Moreno AC, Clara RO, Coimbra JB, Júlio AR, Albuquerque RC, Oliveira EM, Maria-Engler SS, Campa A.

FEBS J. 2013 Oct;280(19):4782-92. doi: 10.1111/febs.12444. Epub 2013 Aug 22.


Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.

Levina V, Su Y, Gorelik E.

Clin Dev Immunol. 2012;2012:173029. doi: 10.1155/2012/173029. Epub 2012 May 13.


Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway.

Peng L, Ran YL, Hu H, Yu L, Liu Q, Zhou Z, Sun YM, Sun LC, Pan J, Sun LX, Zhao P, Yang ZH.

Carcinogenesis. 2009 Oct;30(10):1660-9. doi: 10.1093/carcin/bgp178. Epub 2009 Jul 22.


Role of indoleamine 2,3-dioxygenase in health and disease.

Yeung AW, Terentis AC, King NJ, Thomas SR.

Clin Sci (Lond). 2015 Oct;129(7):601-72. doi: 10.1042/CS20140392. Review.


Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.

Prachason T, Konhan K, Pongnarin P, Chatsiricharoenkul S, Suputtamongkol Y, Limwongse C.

PLoS Negl Trop Dis. 2012;6(7):e1731. doi: 10.1371/journal.pntd.0001731. Epub 2012 Jul 31.


Indoleamine 2,3-dioxygenase 1 (IDO1) is up-regulated in thyroid carcinoma and drives the development of an immunosuppressant tumor microenvironment.

Moretti S, Menicali E, Voce P, Morelli S, Cantarelli S, Sponziello M, Colella R, Fallarino F, Orabona C, Alunno A, de Biase D, Bini V, Mameli MG, Filetti S, Gerli R, Macchiarulo A, Melillo RM, Tallini G, Santoro M, Puccetti P, Avenia N, Puxeddu E.

J Clin Endocrinol Metab. 2014 May;99(5):E832-40. doi: 10.1210/jc.2013-3351. Epub 2014 Feb 11.


The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells.

Opitz CA, Litzenburger UM, Opitz U, Sahm F, Ochs K, Lutz C, Wick W, Platten M.

PLoS One. 2011;6(5):e19823. doi: 10.1371/journal.pone.0019823. Epub 2011 May 20.


Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration.

Liu XQ, Lu K, Feng LL, Ding M, Gao JM, Ge XL, Wang X.

Leuk Lymphoma. 2014 Feb;55(2):405-14. doi: 10.3109/10428194.2013.804917. Epub 2013 Jun 26.


Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation.

Zhong W, Gao L, Zhou Z, Lin H, Chen C, Huang P, Huang W, Zhou C, Huang S, Nie L, Liu Y, Chen Y, Zhou D, Lv Z.

Oncotarget. 2017 Jun 20;8(25):40486-40500. doi: 10.18632/oncotarget.17119.

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