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Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium.

Gross KM, Zhou W, Breindel JL, Ouyang J, Jin DX, Sokol ES, Gupta PB, Huber K, Zou L, Kuperwasser C.

Cell Rep. 2019 Jul 9;28(2):394-407.e6. doi: 10.1016/j.celrep.2019.06.043.


Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.

Cui Y, Palii SS, Innes CL, Paules RS.

Cell Cycle. 2014;13(22):3541-50. doi: 10.4161/15384101.2014.960729.


Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.

Liu S, Opiyo SO, Manthey K, Glanzer JG, Ashley AK, Amerin C, Troksa K, Shrivastav M, Nickoloff JA, Oakley GG.

Nucleic Acids Res. 2012 Nov;40(21):10780-94. doi: 10.1093/nar/gks849. Epub 2012 Sep 12.


Slug controls stem/progenitor cell growth dynamics during mammary gland morphogenesis.

Nassour M, Idoux-Gillet Y, Selmi A, Côme C, Faraldo ML, Deugnier MA, Savagner P.

PLoS One. 2012;7(12):e53498. doi: 10.1371/journal.pone.0053498. Epub 2012 Dec 27.


The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.

Brestovitsky A, Nebenzahl-Sharon K, Kechker P, Sharf R, Kleinberger T.

PLoS Pathog. 2016 Feb 11;12(2):e1005420. doi: 10.1371/journal.ppat.1005420. eCollection 2016 Feb.


Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair.

Pedram A, Razandi M, Evinger AJ, Lee E, Levin ER.

Mol Biol Cell. 2009 Jul;20(14):3374-89. doi: 10.1091/mbc.E09-01-0085. Epub 2009 May 28.


STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation.

Koganti S, Hui-Yuen J, McAllister S, Gardner B, Grasser F, Palendira U, Tangye SG, Freeman AF, Bhaduri-McIntosh S.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4946-51. doi: 10.1073/pnas.1400683111. Epub 2014 Mar 17.


[Analysis of irradiation-induced repair foci in mouse embryonic stem cells].

Suvorova II, Pospelov VA.

Tsitologiia. 2014;56(5):340-5. Russian.


Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit.

Palii SS, Cui Y, Innes CL, Paules RS.

Cell Cycle. 2013 Apr 1;12(7):1105-18. doi: 10.4161/cc.24127. Epub 2013 Mar 5.


Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor.

Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T.

Carcinogenesis. 2013 Nov;34(11):2486-97. doi: 10.1093/carcin/bgt240. Epub 2013 Jul 3.


DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.

Ashley AK, Shrivastav M, Nie J, Amerin C, Troksa K, Glanzer JG, Liu S, Opiyo SO, Dimitrova DD, Le P, Sishc B, Bailey SM, Oakley GG, Nickoloff JA.

DNA Repair (Amst). 2014 Sep;21:131-9. doi: 10.1016/j.dnarep.2014.04.008. Epub 2014 May 10.


Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction.

Xiao G, Kue P, Bhosle R, Bargonetti J.

Cell Cycle. 2015;14(5):744-54. doi: 10.1080/15384101.2014.997517.


Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling.

Zhang B, Wang E, Dai H, Shen J, Hsieh HJ, Lu X, Peng G.

J Biol Chem. 2014 Dec 5;289(49):34284-95. doi: 10.1074/jbc.M114.587113. Epub 2014 Oct 9.


Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.

Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK.

J Biol Chem. 2003 Apr 25;278(17):14806-11. Epub 2003 Feb 14.


The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice.

Adeyemi RO, Pintel DJ.

J Virol. 2014 Sep 1;88(17):10189-99. doi: 10.1128/JVI.01412-14. Epub 2014 Jun 25.


Inhibition of ATR-dependent signaling by protoapigenone and its derivative sensitizes cancer cells to interstrand cross-link-generating agents in vitro and in vivo.

Wang HC, Lee AY, Chou WC, Wu CC, Tseng CN, Liu KY, Lin WL, Chang FR, Chuang DW, Hunyadi A, Wu YC.

Mol Cancer Ther. 2012 Jul;11(7):1443-53. doi: 10.1158/1535-7163.MCT-11-0921. Epub 2012 Apr 24.


Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation.

Saha J, Wang M, Cucinotta FA.

DNA Repair (Amst). 2013 Dec;12(12):1143-51. doi: 10.1016/j.dnarep.2013.10.004. Epub 2013 Nov 12.


DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

Enriquez-Rios V, Dumitrache LC, Downing SM, Li Y, Brown EJ, Russell HR, McKinnon PJ.

J Neurosci. 2017 Jan 25;37(4):893-905. doi: 10.1523/JNEUROSCI.4213-15.2016.


53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response.

Martínez P, Flores JM, Blasco MA.

J Cell Biol. 2012 Apr 16;197(2):283-300. doi: 10.1083/jcb.201110124.


Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses.

Wei L, Zhu S, Wang J, Quan R, Yan X, Li Z, Hou L, Wang N, Yang Y, Jiang H, Liu J.

Sci Rep. 2016 Dec 16;6:39444. doi: 10.1038/srep39444.

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