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Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood-Brain Barrier Integrity in Stroke.

Zhang Y, Zhang X, Wei Q, Leng S, Li C, Han B, Bai Y, Zhang H, Yao H.

Transl Stroke Res. 2019 Jul 9. doi: 10.1007/s12975-019-00711-0. [Epub ahead of print]


Sigma-1 receptor activation alleviates blood-brain barrier dysfunction in vascular dementia mice.

Liu DY, Chi TY, Ji XF, Liu P, Qi XX, Zhu L, Wang ZQ, Li L, Chen L, Zou LB.

Exp Neurol. 2018 Oct;308:90-99. doi: 10.1016/j.expneurol.2018.07.002. Epub 2018 Jul 10.


Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells.

Zechariah A, ElAli A, Hagemann N, Jin F, Doeppner TR, Helfrich I, Mies G, Hermann DM.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1561-7. doi: 10.1161/ATVBAHA.112.300749. Epub 2013 Apr 4. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):e129.


Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke.

He S, Wang C, Dong H, Xia F, Zhou H, Jiang X, Pei C, Ren H, Li H, Li R, Xu H.

Autophagy. 2012 Nov;8(11):1621-7. doi: 10.4161/auto.21561. Epub 2012 Aug 9.


Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression.

Zhang Y, Lv X, Bai Y, Zhu X, Wu X, Chao J, Duan M, Buch S, Chen L, Yao H.

J Neuroinflammation. 2015 Feb 17;12:29. doi: 10.1186/s12974-015-0250-7.


MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes.

Wan Y, Jin HJ, Zhu YY, Fang Z, Mao L, He Q, Xia YP, Li M, Li Y, Chen X, Hu B.

FASEB J. 2018 Jun;32(6):3133-3148. doi: 10.1096/fj.201701121R. Epub 2018 Jan 18.


Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia.

Underly RG, Levy M, Hartmann DA, Grant RI, Watson AN, Shih AY.

J Neurosci. 2017 Jan 4;37(1):129-140. doi: 10.1523/JNEUROSCI.2891-16.2016.


Sigma receptor type 1 knockout mice show a mild deficit in plasticity but no significant change in synaptic transmission in the CA1 region of the hippocampus.

Snyder MA, McCann K, Lalande MJ, Thivierge JP, Bergeron R.

J Neurochem. 2016 Sep;138(5):700-9. doi: 10.1111/jnc.13695. Epub 2016 Jul 18.


EphrinB2 Activation Enhances Vascular Repair Mechanisms and Reduces Brain Swelling After Mild Cerebral Ischemia.

Ghori A, Freimann FB, Nieminen-Kelhä M, Kremenetskaia I, Gertz K, Endres M, Vajkoczy P.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):867-878. doi: 10.1161/ATVBAHA.116.308620. Epub 2017 Mar 2.


An Orally Active Allosteric GLP-1 Receptor Agonist Is Neuroprotective in Cellular and Rodent Models of Stroke.

Zhang H, Liu Y, Guan S, Qu D, Wang L, Wang X, Li X, Zhou S, Zhou Y, Wang N, Meng J, Ma X.

PLoS One. 2016 Feb 10;11(2):e0148827. doi: 10.1371/journal.pone.0148827. eCollection 2016.


The effect of moderate hypothermia in acute ischemic stroke on pericyte migration: an ultrastructural study.

Duz B, Oztas E, Erginay T, Erdogan E, Gonul E.

Cryobiology. 2007 Dec;55(3):279-84. Epub 2007 Sep 7.


Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke.

Roth M, Gaceb A, Enström A, Padel T, Genové G, Özen I, Paul G.

FASEB J. 2019 Aug;33(8):8990-8998. doi: 10.1096/fj.201900153R. Epub 2019 May 2.


Nitration of TRPM2 as a Molecular Switch Induces Autophagy During Brain Pericyte Injury.

Jiang Q, Gao Y, Wang C, Tao R, Wu Y, Zhan K, Liao M, Lu N, Lu Y, Wilcox CS, Luo J, Jiang LH, Yang W, Han F.

Antioxid Redox Signal. 2017 Dec 1;27(16):1297-1316. doi: 10.1089/ars.2016.6873. Epub 2017 Apr 18.


Sigma-1 Receptor Regulates Mitochondrial Function in Glucose- and Oxygen-Deprived Retinal Ganglion Cells.

Ellis DZ, Li L, Park Y, He S, Mueller B, Yorio T.

Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2755-2764. doi: 10.1167/iovs.16-19199.


Detrimental role of pericyte Nox4 in the acute phase of brain ischemia.

Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K, Kitazono T.

J Cereb Blood Flow Metab. 2016 Jun;36(6):1143-54. doi: 10.1177/0271678X15606456. Epub 2015 Oct 13.


Vascular endothelial growth factor promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra.

Zechariah A, ElAli A, Doeppner TR, Jin F, Hasan MR, Helfrich I, Mies G, Hermann DM.

Stroke. 2013 Jun;44(6):1690-7. doi: 10.1161/STROKEAHA.111.000240. Epub 2013 Apr 30.


cPKCγ-Modulated Autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mTOR Pathway.

Wei H, Li Y, Han S, Liu S, Zhang N, Zhao L, Li S, Li J.

Transl Stroke Res. 2016 Dec;7(6):497-511. Epub 2016 Aug 10.


The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.

Sánchez-Blázquez P, Pozo-Rodrigálvarez A, Merlos M, Garzón J.

Mol Neurobiol. 2018 Jun;55(6):4940-4951. doi: 10.1007/s12035-017-0697-x. Epub 2017 Aug 5.


Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke.

Jin AY, Tuor UI, Rushforth D, Kaur J, Muller RN, Petterson JL, Boutry S, Barber PA.

BMC Neurosci. 2010 Feb 2;11:12. doi: 10.1186/1471-2202-11-12.


Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo.

Christ MG, Huesmann H, Nagel H, Kern A, Behl C.

Cells. 2019 Mar 2;8(3). pii: E211. doi: 10.3390/cells8030211.

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