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The HtrA3 protease promotes drug-induced death of lung cancer cells by cleavage of the X-linked inhibitor of apoptosis protein (XIAP).

Wenta T, Rychlowski M, Jurewicz E, Jarzab M, Zurawa-Janicka D, Filipek A, Lipinska B.

FEBS J. 2019 Nov;286(22):4579-4596. doi: 10.1111/febs.14977. Epub 2019 Jul 11.


HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin.

Wenta T, Zurawa-Janicka D, Rychlowski M, Jarzab M, Glaza P, Lipinska A, Bienkowska-Szewczyk K, Herman-Antosiewicz A, Skorko-Glonek J, Lipinska B.

J Proteomics. 2018 Apr 15;177:88-111. doi: 10.1016/j.jprot.2018.02.022. Epub 2018 Mar 2.


The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease.

Wenta T, Glaza P, Jarząb M, Zarzecka U, Żurawa-Janicka D, Lesner A, Skórko-Glonek J, Lipińska B.

Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1141-1151. doi: 10.1016/j.bbapap.2017.06.013. Epub 2017 Jun 20.


Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains.

Glaza P, Osipiuk J, Wenta T, Zurawa-Janicka D, Jarzab M, Lesner A, Banecki B, Skorko-Glonek J, Joachimiak A, Lipinska B.

PLoS One. 2015 Jun 25;10(6):e0131142. doi: 10.1371/journal.pone.0131142. eCollection 2015.


High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines.

Beleford D, Rattan R, Chien J, Shridhar V.

J Biol Chem. 2010 Apr 16;285(16):12011-27. doi: 10.1074/jbc.M109.097790. Epub 2010 Feb 12.


Peptides mimicking the unique ARTS-XIAP binding site promote apoptotic cell death in cultured cancer cells.

Edison N, Reingewertz TH, Gottfried Y, Lev T, Zuri D, Maniv I, Carp MJ, Shalev G, Friedler A, Larisch S.

Clin Cancer Res. 2012 May 1;18(9):2569-78. doi: 10.1158/1078-0432.CCR-11-1430. Epub 2012 Mar 5.


Methylation induced gene silencing of HtrA3 in smoking-related lung cancer.

Beleford D, Liu Z, Rattan R, Quagliuolo L, Boccellino M, Baldi A, Maguire J, Staub J, Molina J, Shridhar V.

Clin Cancer Res. 2010 Jan 15;16(2):398-409. doi: 10.1158/1078-0432.CCR-09-1677. Epub 2010 Jan 12.


Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response.

Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin JH.

Mol Biol Cell. 2014 May;25(9):1411-20. doi: 10.1091/mbc.E13-11-0664. Epub 2014 Mar 12.


Antagonism between HTRA3 and TGFβ1 Contributes to Metastasis in Non-Small Cell Lung Cancer.

Zhao J, Feng M, Liu D, Liu H, Shi M, Zhang J, Qu J.

Cancer Res. 2019 Jun 1;79(11):2853-2864. doi: 10.1158/0008-5472.CAN-18-2507. Epub 2019 Apr 2.


Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus.

Nowak D, Boehrer S, Brieger A, Kim SZ, Schaaf S, Hoelzer D, Mitrou PS, Weidmann E, Chow KU.

Leuk Lymphoma. 2004 Jul;45(7):1429-36.


The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP.

Fang Y, Yu Y, Hou Q, Zheng X, Zhang M, Zhang D, Li J, Wu XR, Huang C.

J Biol Chem. 2012 Oct 12;287(42):35234-43. doi: 10.1074/jbc.M112.389494. Epub 2012 Aug 15.


Inhibition of HTRA3 stimulates trophoblast invasion during human placental development.

Singh H, Makino SI, Endo Y, Nie G.

Placenta. 2010 Dec;31(12):1085-92. doi: 10.1016/j.placenta.2010.10.003. Epub 2010 Oct 29.


Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.

Tomicic MT, Christmann M, Kaina B.

J Pharmacol Exp Ther. 2010 Jan;332(1):316-25. doi: 10.1124/jpet.109.159962. Epub 2009 Oct 7.


Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells.

Metwalli AR, Khanbolooki S, Jinesh G, Sundi D, Shah JB, Shrader M, Choi W, Lashinger LM, Chunduru S, McConkey DJ, McKinlay M, Kamat AM.

Cancer Biol Ther. 2010 Nov 1;10(9):885-92. doi: 10.4161/cbt.10.9.13237. Epub 2010 Nov 1.


Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death.

Augeri DJ, Langenfeld E, Castle M, Gilleran JA, Langenfeld J.

Mol Cancer. 2016 Apr 6;15:27. doi: 10.1186/s12943-016-0511-9.


Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.

Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk RG, Durkin JP, Mayer LD, LaCasse EC.

Clin Cancer Res. 2003 Jul;9(7):2826-36.


X-linked inhibitor regulating TRAIL-induced apoptosis in chemoresistant human primary glioblastoma cells.

Roa WH, Chen H, Fulton D, Gulavita S, Shaw A, Th'ng J, Farr-Jones M, Moore R, Petruk K.

Clin Invest Med. 2003 Oct;26(5):231-42.


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