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Items: 1 to 20 of 102

1.

Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event.

Talmon M, Rossi S, Lim D, Pollastro F, Palattella G, Ruffinatti FA, Marotta P, Boldorini R, Genazzani AA, Fresu LG.

J Biol Chem. 2019 Aug 16;294(33):12472-12482. doi: 10.1074/jbc.RA119.007763. Epub 2019 Jun 27.

PMID:
31248983
2.

Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells.

Pan S, Sharma P, Shah SD, Deshpande DA.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L154-L165. doi: 10.1152/ajplung.00106.2017. Epub 2017 Apr 27.

3.

Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.

Sharma P, Panebra A, Pera T, Tiegs BC, Hershfeld A, Kenyon LC, Deshpande DA.

Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L365-76. doi: 10.1152/ajplung.00373.2015. Epub 2015 Dec 18.

4.
5.

The cellular and molecular basis of bitter tastant-induced bronchodilation.

Zhang CH, Lifshitz LM, Uy KF, Ikebe M, Fogarty KE, ZhuGe R.

PLoS Biol. 2013;11(3):e1001501. doi: 10.1371/journal.pbio.1001501. Epub 2013 Mar 5. Erratum in: PLoS Biol. 2013 Mar;11(3). doi:10.1371/annotation/7899a865-d68b-45bd-8b9b-ec6f50c9308a.

6.

The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.

Santo-Domingo J, Vay L, Hernández-Sanmiguel E, Lobatón CD, Moreno A, Montero M, Alvarez J.

Br J Pharmacol. 2007 Jul;151(5):647-54. Epub 2007 Apr 30.

7.

Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3.

Kim D, Woo JA, Geffken E, An SS, Liggett SB.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):762-771. doi: 10.1165/rcmb.2016-0373OC.

8.

Artesunate attenuates airway resistance in vivo and relaxes airway smooth muscle cells in vitro via bitter taste receptor-dependent calcium signalling.

Wang Y, Wang A, Zhang M, Zeng H, Lu Y, Liu L, Li J, Deng L.

Exp Physiol. 2019 Feb;104(2):231-243. doi: 10.1113/EP086824. Epub 2018 Dec 11.

PMID:
30379382
9.

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.

Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB.

Nat Med. 2010 Nov;16(11):1299-304. doi: 10.1038/nm.2237. Epub 2010 Oct 24.

10.

Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors.

Robinett KS, Deshpande DA, Malone MM, Liggett SB.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):1069-74. doi: 10.1165/rcmb.2011-0061OC. Epub 2011 Jun 3.

11.

TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.

An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA Jr, Liggett SB.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L304-11. doi: 10.1152/ajplung.00126.2012. Epub 2012 Jun 8.

12.

Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells.

Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri RA Jr, Liggett SB.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):678-83. doi: 10.1165/rcmb.2013-0439RC.

13.

Inflammation alters regional mitochondrial Ca²+ in human airway smooth muscle cells.

Delmotte P, Yang B, Thompson MA, Pabelick CM, Prakash YS, Sieck GC.

Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C244-56. doi: 10.1152/ajpcell.00414.2011. Epub 2012 Jun 6.

14.

β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function.

Kim D, Pauer SH, Yong HM, An SS, Liggett SB.

J Biol Chem. 2016 Aug 19;291(34):17616-28. doi: 10.1074/jbc.M116.722736. Epub 2016 Jun 24.

15.

Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma.

Liggett SB.

Trans Am Clin Climatol Assoc. 2014;125:64-74; discussion 74-5.

16.

The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.

Pulkkinen V, Manson ML, Säfholm J, Adner M, Dahlén SE.

Am J Physiol Lung Cell Mol Physiol. 2012 Dec 1;303(11):L956-66. doi: 10.1152/ajplung.00205.2012. Epub 2012 Sep 7.

17.

Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators.

Liggett SB.

Expert Opin Ther Targets. 2013 Jun;17(6):721-31. doi: 10.1517/14728222.2013.782395. Epub 2013 Apr 12. Review.

18.

Calcium/calmodulin-dependent kinase 2 mediates Epac-induced spontaneous transient outward currents in rat vascular smooth muscle.

Humphries ESA, Kamishima T, Quayle JM, Dart C.

J Physiol. 2017 Sep 15;595(18):6147-6164. doi: 10.1113/JP274754. Epub 2017 Aug 14.

19.

Modulation of mitochondrial Ca(2+) uptake by estrogen receptor agonists and antagonists.

Lobatón CD, Vay L, Hernández-Sanmiguel E, Santodomingo J, Moreno A, Montero M, Alvarez J.

Br J Pharmacol. 2005 Aug;145(7):862-71.

20.

TNFα decreases mitochondrial movement in human airway smooth muscle.

Delmotte P, Zavaletta VA, Thompson MA, Prakash YS, Sieck GC.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L166-L176. doi: 10.1152/ajplung.00538.2016. Epub 2017 May 4.

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