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Nicotinamide Riboside, an NAD + Precursor, Reduces Hepatic Stellate Cell Activation and Attenuates Liver Fibrosis in a Diet-induced Mouse Model of Liver Fibrosis (OR24-06-19).

Pham T, Bae M, Kim MB, Lee Y, Hu S, Kang H, Park YK, Lee JY.

Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz031.OR24-06-19. doi: 10.1093/cdn/nzz031.OR24-06-19. eCollection 2019 Jun.


Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis.

Pham TX, Bae M, Kim MB, Lee Y, Hu S, Kang H, Park YK, Lee JY.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2451-2463. doi: 10.1016/j.bbadis.2019.06.009. Epub 2019 Jun 11.


Sugar Kelp (Saccharina latissima) Inhibits Hepatic Inflammation and Fibrosis with Increased Metabolic Rates in a Mouse Model of Diet-induced Nonalcoholic Steatohepatitis (OR24-08-19).

Kim MB, Lee Y, Bae M, Kang H, Hu S, Pham T, Lee JY, Park YK.

Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz031.OR24-08-19. doi: 10.1093/cdn/nzz031.OR24-08-19. eCollection 2019 Jun.


Nicotinamide riboside protects against liver fibrosis induced by CCl4 via regulating the acetylation of Smads signaling pathway.

Jiang R, Zhou Y, Wang S, Pang N, Huang Y, Ye M, Wan T, Qiu Y, Pei L, Jiang X, Huang Y, Yang H, Ling W, Li X, Zhang Z, Yang L.

Life Sci. 2019 May 15;225:20-28. doi: 10.1016/j.lfs.2019.03.064. Epub 2019 Mar 27.


Fibronectin Type III Domain-Containing 5 Attenuates Liver Fibrosis Via Inhibition of Hepatic Stellate Cell Activation.

Zhou B, Ling L, Zhang F, Liu TY, Zhou H, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ.

Cell Physiol Biochem. 2018;48(1):227-236. doi: 10.1159/000491722. Epub 2018 Jul 13.


Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway.

Wang S, Wan T, Ye M, Qiu Y, Pei L, Jiang R, Pang N, Huang Y, Liang B, Ling W, Lin X, Zhang Z, Yang L.

Redox Biol. 2018 Jul;17:89-98. doi: 10.1016/j.redox.2018.04.006. Epub 2018 Apr 5.


Neutrophil-Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis.

Zhou Z, Xu MJ, Cai Y, Wang W, Jiang JX, Varga ZV, Feng D, Pacher P, Kunos G, Torok NJ, Gao B.

Cell Mol Gastroenterol Hepatol. 2018 Jan 8;5(3):399-413. doi: 10.1016/j.jcmgh.2018.01.003. eCollection 2018 Mar.


Spirulina supplementation in a mouse model of diet-induced liver fibrosis reduced the pro-inflammatory response of splenocytes.

Pham TX, Lee Y, Bae M, Hu S, Kang H, Kim MB, Park YK, Lee JY.

Br J Nutr. 2019 Apr;121(7):748-755. doi: 10.1017/S0007114519000126. Epub 2019 Feb 26.


Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J.

Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16.


Liver fatty acid binding protein (L-Fabp) modulates murine stellate cell activation and diet-induced nonalcoholic fatty liver disease.

Chen A, Tang Y, Davis V, Hsu FF, Kennedy SM, Song H, Turk J, Brunt EM, Newberry EP, Davidson NO.

Hepatology. 2013 Jun;57(6):2202-12. doi: 10.1002/hep.26318. Epub 2013 May 15.


Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice.

Zhang K, Kim H, Fu Z, Qiu Y, Yang Z, Wang J, Zhang D, Tong X, Yin L, Li J, Wu J, Qi NR, Houten SM, Zhang R.

Gastroenterology. 2018 Jan;154(1):224-237. doi: 10.1053/j.gastro.2017.09.010. Epub 2017 Sep 18.


Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.

Da Silva Morais A, Abarca-Quinones J, Horsmans Y, Stärkel P, Leclercq IA.

Int J Mol Med. 2007 Jan;19(1):105-12.


Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway.

Wang LF, Wang XN, Huang CC, Hu L, Xiao YF, Guan XH, Qian YS, Deng KY, Xin HB.

Lipids Health Dis. 2017 Apr 27;16(1):82. doi: 10.1186/s12944-017-0464-z.


Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M.

Gastroenterology. 2014 Feb;146(2):539-49.e7. doi: 10.1053/j.gastro.2013.10.059. Epub 2013 Nov 1.


Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase.

Li Z, Ding Q, Ling LP, Wu Y, Meng DX, Li X, Zhang CQ.

World J Gastroenterol. 2018 Feb 21;24(7):819-832. doi: 10.3748/wjg.v24.i7.819.


Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring (P11-003-19).

Brenner C.

Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz048.P11-003-19. doi: 10.1093/cdn/nzz048.P11-003-19. eCollection 2019 Jun.


Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4(-/-) mouse model.

Reiter FP, Wimmer R, Wottke L, Artmann R, Nagel JM, Carranza MO, Mayr D, Rust C, Fickert P, Trauner M, Gerbes AL, Hohenester S, Denk GU.

World J Hepatol. 2016 Mar 18;8(8):401-10. doi: 10.4254/wjh.v8.i8.401.


Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.

Yang SJ, Choi JM, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY.

J Nutr Biochem. 2014 Jan;25(1):66-72. doi: 10.1016/j.jnutbio.2013.09.004. Epub 2013 Oct 10.


Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.

Mukherjee S, Chellappa K, Moffitt A, Ndungu J, Dellinger RW, Davis JG, Agarwal B, Baur JA.

Hepatology. 2017 Feb;65(2):616-630. doi: 10.1002/hep.28912. Epub 2016 Dec 24. Erratum in: Hepatology. 2017 Apr;65(4):1427.


Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.

Nguyen G, Park SY, Le CT, Park WS, Choi DH, Cho EH.

Biochem Biophys Res Commun. 2018 Jan 22;495(4):2649-2656. doi: 10.1016/j.bbrc.2017.12.143. Epub 2017 Dec 24.


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