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Items: 1 to 20 of 96

1.

Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents.

Gao T, Zhang C, Shi X, Guo R, Zhang K, Gu J, Li L, Li S, Zheng Q, Cui M, Cui M, Gao X, Liu Y, Wang L.

Eur J Med Chem. 2019 Jun 6;178:329-340. doi: 10.1016/j.ejmech.2019.06.013. [Epub ahead of print]

PMID:
31200235
2.

Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.

Xing R, Zhang H, Yuan J, Zhang K, Li L, Guo H, Zhao L, Zhang C, Li S, Gao T, Liu Y, Wang L.

Eur J Med Chem. 2017 Oct 20;139:531-541. doi: 10.1016/j.ejmech.2017.08.032. Epub 2017 Aug 14.

PMID:
28830032
3.

Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents.

Liu Y, Li M, Zhang H, Yuan J, Zhang C, Zhang K, Guo H, Zhao L, Du Y, Wang L, Ren L.

Eur J Med Chem. 2016 Jun 10;115:245-56. doi: 10.1016/j.ejmech.2016.03.032. Epub 2016 Mar 21.

PMID:
27017552
4.

Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis.

Liu Y, Zhang C, Zhang H, Li M, Yuan J, Zhang Y, Zhou J, Guo H, Zhao L, Du Y, Wang L, Ren L.

Eur J Med Chem. 2015 Mar 26;93:142-55. doi: 10.1016/j.ejmech.2015.01.055. Epub 2015 Jan 28.

PMID:
25668494
6.

Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase.

Wang M, Yang J, Yuan M, Xue L, Li H, Tian C, Wang X, Liu J, Zhang Z.

Eur J Med Chem. 2017 Mar 10;128:88-97. doi: 10.1016/j.ejmech.2017.01.033. Epub 2017 Jan 25.

PMID:
28152430
7.

Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.

Gangjee A, Devraj R, McGuire JJ, Kisliuk RL, Queener SF, Barrows LR.

J Med Chem. 1994 Apr 15;37(8):1169-76.

PMID:
8164259
8.

Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.

Gangjee A, Yu J, McGuire JJ, Cody V, Galitsky N, Kisliuk RL, Queener SF.

J Med Chem. 2000 Oct 19;43(21):3837-51.

PMID:
11052789
9.

2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.

Gangjee A, Vasudevan A, Queener SF, Kisliuk RL.

J Med Chem. 1996 Mar 29;39(7):1438-46. Erratum in: J Med Chem 1996 Aug 2;39(16):3228.

PMID:
8691474
11.

Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge.

Li H, Fang F, Liu Y, Xue L, Wang M, Guo Y, Wang X, Tian C, Liu J, Zhang Z.

Bioorg Med Chem. 2018 May 15;26(9):2674-2685. doi: 10.1016/j.bmc.2018.04.035. Epub 2018 Apr 19.

PMID:
29691154
13.

2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.

Gangjee A, Jain HD, Phan J, Guo X, Queener SF, Kisliuk RL.

Bioorg Med Chem. 2010 Jan 15;18(2):953-61. doi: 10.1016/j.bmc.2009.11.029. Epub 2009 Dec 26.

14.
16.
17.

Synthesis and antitumor activity of pyrrolo[2,3-d]pyrimidine antifolates with a bridge chain containing a nitrogen atom.

Aso K, Hitaka T, Yukishige K, Ootsu K, Akimoto H.

Chem Pharm Bull (Tokyo). 1995 Feb;43(2):256-61.

PMID:
7728932
18.

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.

Gangjee A, Vidwans A, Elzein E, McGuire JJ, Queener SF, Kisliuk RL.

J Med Chem. 2001 Jun 7;44(12):1993-2003.

PMID:
11384244
19.
20.

Dihydrofolate reductase inhibition effect of 5-substituted pyrido[2,3-d]pyrimidines: Synthesis, antitumor activity and molecular modeling study.

Abdelaziz OA, El Husseiny WM, Selim KB, Eisa HM.

Bioorg Chem. 2019 Jun 18;90:103076. doi: 10.1016/j.bioorg.2019.103076. [Epub ahead of print]

PMID:
31260878

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