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Items: 1 to 20 of 101

1.

Impact of phase separation morphology on release mechanism of amorphous solid dispersions.

Han YR, Ma Y, Lee PI.

Eur J Pharm Sci. 2019 Aug 1;136:104955. doi: 10.1016/j.ejps.2019.104955. Epub 2019 Jun 12.

PMID:
31199980
2.

Phase Behavior of Ritonavir Amorphous Solid Dispersions during Hydration and Dissolution.

Purohit HS, Taylor LS.

Pharm Res. 2017 Dec;34(12):2842-2861. doi: 10.1007/s11095-017-2265-5. Epub 2017 Sep 27.

PMID:
28956218
3.

Insights into the Dissolution Mechanism of Ritonavir-Copovidone Amorphous Solid Dispersions: Importance of Congruent Release for Enhanced Performance.

Indulkar AS, Lou X, Zhang GGZ, Taylor LS.

Mol Pharm. 2019 Mar 4;16(3):1327-1339. doi: 10.1021/acs.molpharmaceut.8b01261. Epub 2019 Feb 5.

PMID:
30669846
4.

Enhanced kinetic solubility profiles of indomethacin amorphous solid dispersions in poly(2-hydroxyethyl methacrylate) hydrogels.

Sun DD, Ju TC, Lee PI.

Eur J Pharm Biopharm. 2012 May;81(1):149-58. doi: 10.1016/j.ejpb.2011.12.016. Epub 2012 Jan 2.

PMID:
22233548
5.

Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance.

Chen H, Pui Y, Liu C, Chen Z, Su CC, Hageman M, Hussain M, Haskell R, Stefanski K, Foster K, Gudmundsson O, Qian F.

J Pharm Sci. 2018 Jan;107(1):317-326. doi: 10.1016/j.xphs.2017.10.028. Epub 2017 Oct 26.

PMID:
29107047
6.

Congruent release of drug and polymer: A "sweet spot" in the dissolution of amorphous solid dispersions.

Saboo S, Mugheirbi NA, Zemlyanov DY, Kestur US, Taylor LS.

J Control Release. 2019 Mar 28;298:68-82. doi: 10.1016/j.jconrel.2019.01.039. Epub 2019 Feb 4.

PMID:
30731151
7.

Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction.

Chen Y, Wang S, Wang S, Liu C, Su C, Hageman M, Hussain M, Haskell R, Stefanski K, Qian F.

Pharm Res. 2016 Oct;33(10):2445-58. doi: 10.1007/s11095-016-1969-2. Epub 2016 Jun 9.

PMID:
27283830
8.

Phase behavior of poly(vinylpyrrolidone) containing amorphous solid dispersions in the presence of moisture.

Rumondor AC, Marsac PJ, Stanford LA, Taylor LS.

Mol Pharm. 2009 Sep-Oct;6(5):1492-505. doi: 10.1021/mp900050c.

PMID:
19634917
9.

Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers.

Sun DD, Lee PI.

J Control Release. 2015 Aug 10;211:85-93. doi: 10.1016/j.jconrel.2015.06.004. Epub 2015 Jun 6.

PMID:
26054795
10.

Microstructure Formation for Improved Dissolution Performance of Lopinavir Amorphous Solid Dispersions.

Li N, Taylor LS.

Mol Pharm. 2019 Apr 1;16(4):1751-1765. doi: 10.1021/acs.molpharmaceut.9b00117. Epub 2019 Mar 11.

PMID:
30811205
11.

A Single Hydrogen to Fluorine Substitution Reverses the Trend of Surface Composition Enrichment of Sorafenib Amorphous Solid Dispersion upon Moisture Exposure.

Chen Y, Chen H, Wang S, Liu C, Qian F.

Pharm Res. 2019 May 17;36(7):105. doi: 10.1007/s11095-019-2632-5.

PMID:
31102031
12.
13.

Molecular structure and impact of amorphization strategies on intrinsic dissolution of spray dried indomethacin.

Li Y, Rantanen J, Yang M, Bohr A.

Eur J Pharm Sci. 2019 Mar 1;129:1-9. doi: 10.1016/j.ejps.2018.12.010. Epub 2018 Dec 13.

PMID:
30553059
14.

Novel supercritical carbon dioxide impregnation technique for the production of amorphous solid drug dispersions: a comparison to hot melt extrusion.

Potter C, Tian Y, Walker G, McCoy C, Hornsby P, Donnelly C, Jones DS, Andrews GP.

Mol Pharm. 2015 May 4;12(5):1377-90. doi: 10.1021/mp500644h. Epub 2015 Mar 31.

PMID:
25730138
15.

Viewing Molecular and Interface Interactions of Curcumin Amorphous Solid Dispersions for Comprehending Dissolution Mechanisms.

Li J, Wang X, Li C, Fan N, Wang J, He Z, Sun J.

Mol Pharm. 2017 Aug 7;14(8):2781-2792. doi: 10.1021/acs.molpharmaceut.7b00319. Epub 2017 Jul 7.

PMID:
28661679
16.
17.

Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type.

Jackson MJ, Kestur US, Hussain MA, Taylor LS.

Mol Pharm. 2016 Jan 4;13(1):223-31. doi: 10.1021/acs.molpharmaceut.5b00652. Epub 2015 Dec 9.

PMID:
26618718
18.

Non-invasive insight into the release mechanisms of a poorly soluble drug from amorphous solid dispersions by confocal Raman microscopy.

Punčochová K, Vukosavljevic B, Hanuš J, Beránek J, Windbergs M, Štěpánek F.

Eur J Pharm Biopharm. 2016 Apr;101:119-25. doi: 10.1016/j.ejpb.2016.02.001. Epub 2016 Feb 6.

PMID:
26861928
19.
20.

Dissolution performance of binary amorphous drug combinations--Impact of a second drug on the maximum achievable supersaturation.

Trasi NS, Taylor LS.

Int J Pharm. 2015 Dec 30;496(2):282-90. doi: 10.1016/j.ijpharm.2015.10.026. Epub 2015 Oct 9.

PMID:
26456250

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