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Items: 1 to 20 of 97

1.

Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease.

Nam G, Ji Y, Lee HJ, Kang J, Yi Y, Kim M, Lin Y, Lee YH, Lim MH.

ACS Chem Neurosci. 2019 Jun 20. doi: 10.1021/acschemneuro.9b00232. [Epub ahead of print]

PMID:
31199606
2.

Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer's Disease.

Derrick JS, Kerr RA, Korshavn KJ, McLane MJ, Kang J, Nam E, Ramamoorthy A, Ruotolo BT, Lim MH.

Inorg Chem. 2016 May 16;55(10):5000-13. doi: 10.1021/acs.inorgchem.6b00525. Epub 2016 Apr 27.

PMID:
27119456
3.

Tuning Structures and Properties for Developing Novel Chemical Tools toward Distinct Pathogenic Elements in Alzheimer's Disease.

Han J, Lee HJ, Kim KY, Lee SJC, Suh JM, Cho J, Chae J, Lim MH.

ACS Chem Neurosci. 2018 Apr 18;9(4):800-808. doi: 10.1021/acschemneuro.7b00454. Epub 2017 Dec 28.

PMID:
29283241
4.

Regulatory Activities of Dopamine and Its Derivatives toward Metal-Free and Metal-Induced Amyloid-β Aggregation, Oxidative Stress, and Inflammation in Alzheimer's Disease.

Nam E, Derrick JS, Lee S, Kang J, Han J, Lee SJC, Chung SW, Lim MH.

ACS Chem Neurosci. 2018 Nov 21;9(11):2655-2666. doi: 10.1021/acschemneuro.8b00122. Epub 2018 Jun 8.

PMID:
29782798
5.

The ongoing search for small molecules to study metal-associated amyloid-β species in Alzheimer's disease.

Savelieff MG, DeToma AS, Derrick JS, Lim MH.

Acc Chem Res. 2014 Aug 19;47(8):2475-82. doi: 10.1021/ar500152x. Epub 2014 Jul 31.

PMID:
25080056
6.

Strategic Design of 2,2'-Bipyridine Derivatives to Modulate Metal-Amyloid-β Aggregation.

Ji Y, Lee HJ, Kim M, Nam G, Lee SJC, Cho J, Park CM, Lim MH.

Inorg Chem. 2017 Jun 5;56(11):6695-6705. doi: 10.1021/acs.inorgchem.7b00782. Epub 2017 May 9.

PMID:
28485587
7.

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.

Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, Jun D, Sepsova V, Hrabinova M, Soukup O, Kristian P, Gazova Z, Bednarikova Z, Kuca K, Valko M.

J Inorg Biochem. 2016 Aug;161:52-62. doi: 10.1016/j.jinorgbio.2016.05.001. Epub 2016 May 5.

PMID:
27230386
8.

Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.

Beck MW, Derrick JS, Suh JM, Kim M, Korshavn KJ, Kerr RA, Cho WJ, Larsen SD, Ruotolo BT, Ramamoorthy A, Lim MH.

ChemMedChem. 2017 Nov 22;12(22):1828-1838. doi: 10.1002/cmdc.201700456. Epub 2017 Oct 9.

10.

Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives.

Korshavn KJ, Jang M, Kwak YJ, Kochi A, Vertuani S, Bhunia A, Manfredini S, Ramamoorthy A, Lim MH.

Sci Rep. 2015 Dec 10;5:17842. doi: 10.1038/srep17842.

11.

Inhibition of Alzheimer's amyloid-β42 peptide aggregation by a bi-functional bis-tryptoline triazole: key insights from molecular dynamics simulations.

Narang SS, Goyal D, Goyal B.

J Biomol Struct Dyn. 2019 May 3:1-14. doi: 10.1080/07391102.2019.1614093. [Epub ahead of print]

PMID:
31046642
12.

Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.

Lan JS, Xie SS, Li SY, Pan LF, Wang XB, Kong LY.

Bioorg Med Chem. 2014 Nov 1;22(21):6089-104. doi: 10.1016/j.bmc.2014.08.035. Epub 2014 Sep 15.

PMID:
25282654
13.

Iminodiacetic Acid-Modified Human Serum Albumin: A Multifunctional Agent against Metal-Associated Amyloid β-Protein Aggregation and Cytotoxicity.

Xie B, Zhang H, Li X, Dong X, Sun Y.

ACS Chem Neurosci. 2017 Oct 18;8(10):2214-2224. doi: 10.1021/acschemneuro.7b00128. Epub 2017 Aug 14.

PMID:
28767224
14.

α-bisabolol β-D-fucopyranoside as a potential modulator of β-amyloid peptide induced neurotoxicity: An in vitro &in silico study.

Jeyakumar M, Sathya S, Gandhi S, Tharra P, Suryanarayanan V, Singh SK, Baire B, Pandima Devi K.

Bioorg Chem. 2019 Jul;88:102935. doi: 10.1016/j.bioorg.2019.102935. Epub 2019 Apr 19.

PMID:
31030060
15.

Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation.

Kantham S, Chan S, McColl G, Miles JA, Veliyath SK, Deora GS, Dighe SN, Khabbazi S, Parat MO, Ross BP.

ACS Chem Neurosci. 2017 Sep 20;8(9):1901-1912. doi: 10.1021/acschemneuro.7b00071. Epub 2017 Jul 19.

PMID:
28650631
16.

Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.

He X, Park HM, Hyung SJ, DeToma AS, Kim C, Ruotolo BT, Lim MH.

Dalton Trans. 2012 Jun 7;41(21):6558-66. doi: 10.1039/c2dt12207c. Epub 2012 Mar 22.

17.

Alzheimer's disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-β peptide aggregation.

Wallin C, Sholts SB, Österlund N, Luo J, Jarvet J, Roos PM, Ilag L, Gräslund A, Wärmländer SKTS.

Sci Rep. 2017 Oct 31;7(1):14423. doi: 10.1038/s41598-017-13759-5.

18.

Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities.

Zheng H, Youdim MB, Fridkin M.

ACS Chem Neurosci. 2010 Nov 17;1(11):737-46. doi: 10.1021/cn100069c. Epub 2010 Oct 4.

19.

Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.

Li RS, Wang XB, Hu XJ, Kong LY.

Bioorg Med Chem Lett. 2013 May 1;23(9):2636-41. doi: 10.1016/j.bmcl.2013.02.095. Epub 2013 Mar 1.

PMID:
23511019
20.

Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.

Lee S, Zheng X, Krishnamoorthy J, Savelieff MG, Park HM, Brender JR, Kim JH, Derrick JS, Kochi A, Lee HJ, Kim C, Ramamoorthy A, Bowers MT, Lim MH.

J Am Chem Soc. 2014 Jan 8;136(1):299-310. doi: 10.1021/ja409801p. Epub 2013 Dec 27.

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