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Items: 1 to 20 of 97

1.

4-O-methylhonokiol protects against diabetic cardiomyopathy in type 2 diabetic mice by activation of AMPK-mediated cardiac lipid metabolism improvement.

Zheng Z, Ma T, Guo H, Kim KS, Kim KT, Bi L, Zhang Z, Cai L.

J Cell Mol Med. 2019 Jun 14. doi: 10.1111/jcmm.14493. [Epub ahead of print]

2.

4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress.

Ma T, Zheng Z, Guo H, Lian X, Rane MJ, Cai L, Kim KS, Kim KT, Zhang Z, Bi L.

Toxicol Appl Pharmacol. 2019 May 1;370:93-105. doi: 10.1016/j.taap.2019.03.007. Epub 2019 Mar 12.

PMID:
30876865
3.

Magnolia bioactive constituent 4-O-methylhonokiol prevents the impairment of cardiac insulin signaling and the cardiac pathogenesis in high-fat diet-induced obese mice.

Zhang Z, Chen J, Zhou S, Wang S, Cai X, Conklin DJ, Kim KS, Kim KH, Tan Y, Zheng Y, Kim YH, Cai L.

Int J Biol Sci. 2015 Jun 5;11(8):879-91. doi: 10.7150/ijbs.12101. eCollection 2015.

4.

The magnolia bioactive constituent 4-O-methylhonokiol protects against high-fat diet-induced obesity and systemic insulin resistance in mice.

Zhang Z, Chen J, Jiang X, Wang J, Yan X, Zheng Y, Conklin DJ, Kim KS, Kim KH, Tan Y, Kim YH, Cai L.

Oxid Med Cell Longev. 2014;2014:965954. doi: 10.1155/2014/965954. Epub 2014 May 29.

5.

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart.

Yang H, Feng A, Lin S, Yu L, Lin X, Yan X, Lu X, Zhang C.

Cell Death Dis. 2018 Feb 14;9(2):227. doi: 10.1038/s41419-018-0307-5.

6.

Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy.

Al-Damry NT, Attia HA, Al-Rasheed NM, Al-Rasheed NM, Mohamad RA, Al-Amin MA, Dizmiri N, Atteya M.

Biomed Pharmacother. 2018 Nov;107:347-358. doi: 10.1016/j.biopha.2018.07.126. Epub 2018 Aug 9.

PMID:
30099338
7.

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.

Zhang Z, Wang S, Zhou S, Yan X, Wang Y, Chen J, Mellen N, Kong M, Gu J, Tan Y, Zheng Y, Cai L.

J Mol Cell Cardiol. 2014 Dec;77:42-52. doi: 10.1016/j.yjmcc.2014.09.022. Epub 2014 Sep 28.

PMID:
25268649
8.

Inhibition of HDAC3 prevents diabetic cardiomyopathy in OVE26 mice via epigenetic regulation of DUSP5-ERK1/2 pathway.

Xu Z, Tong Q, Zhang Z, Wang S, Zheng Y, Liu Q, Qian LB, Chen SY, Sun J, Cai L.

Clin Sci (Lond). 2017 Jul 5;131(15):1841-1857. doi: 10.1042/CS20170064. Print 2017 Aug 1.

9.

Knockout of CNR1 prevents metabolic stress-induced cardiac injury through improving insulin resistance (IR) injury and endoplasmic reticulum (ER) stress by promoting AMPK-alpha activation.

Pei SJ, Zhu HY, Guo JH, Zhang X, Deng ZJ.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):744-751. doi: 10.1016/j.bbrc.2018.06.070. Epub 2018 Aug 2.

PMID:
29909009
10.

Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.

Wang Y, Feng W, Xue W, Tan Y, Hein DW, Li XK, Cai L.

Diabetes. 2009 Jun;58(6):1391-402. doi: 10.2337/db08-1697. Epub 2009 Mar 26.

11.

4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase.

Lee YK, Choi IS, Ban JO, Lee HJ, Lee US, Han SB, Jung JK, Kim YH, Kim KH, Oh KW, Hong JT.

J Nutr Biochem. 2011 May;22(5):476-86. doi: 10.1016/j.jnutbio.2010.04.002. Epub 2010 Aug 5.

PMID:
20688501
12.

Urocortin attenuates myocardial fibrosis in diabetic rats via the Akt/GSK-3β signaling pathway.

Liu X, Liu C, Li J, Zhang X, Song F, Xu J.

Endocr Res. 2016 May;41(2):148-57. doi: 10.3109/07435800.2015.1094489. Epub 2016 Mar 2.

PMID:
26934363
13.

Protocatechuic Acid, a Phenolic from Sansevieria roxburghiana Leaves, Suppresses Diabetic Cardiomyopathy via Stimulating Glucose Metabolism, Ameliorating Oxidative Stress, and Inhibiting Inflammation.

Bhattacharjee N, Dua TK, Khanra R, Joardar S, Nandy A, Saha A, De Feo V, Dewanjee S.

Front Pharmacol. 2017 May 8;8:251. doi: 10.3389/fphar.2017.00251. eCollection 2017.

14.

Diabetic cardiomyopathy--fact or fiction?

Maisch B, Alter P, Pankuweit S.

Herz. 2011 Mar;36(2):102-15. doi: 10.1007/s00059-011-3429-4.

PMID:
21424347
15.

FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice.

Wu F, Wang B, Zhang S, Shi L, Wang Y, Xiong R, Pan X, Gong F, Li X, Lin Z.

Clin Sci (Lond). 2017 Jul 7;131(15):1877-1893. doi: 10.1042/CS20170271. Print 2017 Aug 1.

PMID:
28559425
16.

Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation.

Chen C, Meng Z, Zheng Y, Hu B, Shen E.

Exp Ther Med. 2018 Jan;15(1):75-84. doi: 10.3892/etm.2017.5375. Epub 2017 Oct 25.

17.

Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.

Zhang B, Zhang J, Zhang C, Zhang X, Ye J, Kuang S, Sun G, Sun X.

Front Pharmacol. 2018 Nov 2;9:1227. doi: 10.3389/fphar.2018.01227. eCollection 2018.

18.

Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats.

Guleria RS, Singh AB, Nizamutdinova IT, Souslova T, Mohammad AA, Kendall JA Jr, Baker KM, Pan J.

J Mol Cell Cardiol. 2013 Apr;57:106-18. doi: 10.1016/j.yjmcc.2013.01.017. Epub 2013 Feb 5.

19.

RANKL-induced osteoclastogenesis is suppressed by 4-O-methylhonokiol in bone marrow-derived macrophages.

Park KR, Kim JY, Kim EC, Yun HM, Hong JT.

Arch Pharm Res. 2017 Aug;40(8):933-942. doi: 10.1007/s12272-017-0932-z. Epub 2017 Jul 24.

PMID:
28736799
20.

Argatroban Attenuates Diabetic Cardiomyopathy in Rats by Reducing Fibrosis, Inflammation, Apoptosis, and Protease-Activated Receptor Expression.

Bulani Y, Sharma SS.

Cardiovasc Drugs Ther. 2017 Jun;31(3):255-267. doi: 10.1007/s10557-017-6732-3.

PMID:
28695302

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